The article focused on the phytochemical and invitro anti-inflammatory activity studies of the methanolic extract of Naregamia alata. The plant aerial parts were extracted successively with Chloroform, methanol, ethanol and water in a Soxhlet extractor and the phytochemical screening of the extracts were carried out using this fraction. The ethanolic extract showed maximum active constituents like alkaloids, phenolics and glycosides. Invitro anti-inflammatory activity studies of the methanolic extract were carried out using Albumin Denaturation method, Heat Induced Hemolysis, HRBC membrane stabilization method and Ant proteinase assay.The standards used were Aspirin, Indomethacin and Diclofenac sodium.The results of various invitro anti-inflammatory studies showed that the methanolic extract of the plant aerial parts were effective at the concentration range of 100-500 µg/ml and was significant.

Keywords : Anti Inflammatory, Methanolic, HRBC Membrane Stabilization, Albumin Denaturation.