Background: Oral hypoglycaemics prescription trends keep on changing in post-menopausal women and thus the drug prescription trend study may prove to be powerful exploratory tool for health care providers. Aims & Objectives: To study the prescribing pattern of oral hypoglycaemics among post menopausal women. Methodology: A prospective observational drug utilization study was conducted in General Medicine OPD & IPD at Karuna Medical College Vilayodi, Chittur for a period of 6 months. The study is based on the data collected from 76 patients who were post menopausal women visiting for the treatment of diabetes. Results: A totally 76 prescriptions were analyzed and\ out of 44 (57.8%) were post menopausal women having diabetes mellitus (DM) and both DM & hypertension (HT). A total of 451 drugs were prescribed, 252 (55.8%) were anti-diabetics, 101 (22.3%) anti-hypertensives, 29 (6.4%) statins, 18 (3.9%) NSAID’s and 51 (11.3%) includes others. A total of 252 anti diabetic drugs prescribed. Biguanides 80 (31.75%) most commonly prescribed, followed by sulfonylureas 65 (25.7%), alpha glucosidase inhibitors 25 (9.9%), thiazolidinediones 8 (3.1%) and the insulin preparations includes 27 (10.7%). Total 47 (18.6%) FDC’s were prescribed. The average number of drugs prescribed per prescription was 2.83 and 150 (59.5%) drugs were prescribed from Essential Drug List 2016 17. Conclusion: In this study it is observed that metformin is most commonly prescribed drug followed by glimepiride, voglibose and insulin preparations. The prescription of metformin justified as these drugs have advantages like it does not cause hypoglycaemia and weight gain due to its peculiar mechanism of action beside having many nonglycaemic advantages like its utility to prevent insulin resistance, metabolic syndrome, fatty liver helping as an adjuvant in keeping check over dyslipidemia and hypertension which is more common in post-menopausal women.[3]

Keywords : Key words: Diabetes mellitus, Post menopausal women, Fixed dose combinations, Rational prescribing.