1, 3-Dithiols and Oxoketene Gem-Dithiols Insertion into Au, Hg, Co and Ni; Synthesis and Biological Investigation of Some Metal Complexes


Authors : Ominya S. Zaky; Mashael M. Barqi; Entesar A. Hassan

Volume/Issue : Volume 8 - 2023, Issue 10 - October

Google Scholar : https://tinyurl.com/352khmsv

Scribd : https://tinyurl.com/5azattp6

DOI : https://doi.org/10.5281/zenodo.10047082

Abstract : Reaction of dimethyl-2-(2-thien-2-yl-2- thioxoethylidene)-1,3-dithiole-4,5-dicarb- oxylate 1 and 1-(4-(1H-indol-3-yl)-6-methyl-2-thioxo-1,2,3,4- tetrahydropyrimidin-5-yl)-3,3-dimercaptoprop-2-en-1- one 10 respectively with transition metal salts, e.g. NaAuCl4.2H2O, NiCl2.6H2O, CoCl2 and HgCl2 furnished the C-S-Metal complexes in a simple and a satisfactory manner. These complexes were screened as antimicrobial agents against a number of important bacteria such as Bacillus subtilus, Staphylococcus and Lactococcus and gave remarkable and observed inhibition zones.

Keywords : Oxoketene Gem-Dithiol, Metal Complexes, Ampicillin, Amphotericin, Sugar Manufacture, Biological Activities.

Reaction of dimethyl-2-(2-thien-2-yl-2- thioxoethylidene)-1,3-dithiole-4,5-dicarb- oxylate 1 and 1-(4-(1H-indol-3-yl)-6-methyl-2-thioxo-1,2,3,4- tetrahydropyrimidin-5-yl)-3,3-dimercaptoprop-2-en-1- one 10 respectively with transition metal salts, e.g. NaAuCl4.2H2O, NiCl2.6H2O, CoCl2 and HgCl2 furnished the C-S-Metal complexes in a simple and a satisfactory manner. These complexes were screened as antimicrobial agents against a number of important bacteria such as Bacillus subtilus, Staphylococcus and Lactococcus and gave remarkable and observed inhibition zones.

Keywords : Oxoketene Gem-Dithiol, Metal Complexes, Ampicillin, Amphotericin, Sugar Manufacture, Biological Activities.

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