1, 4 Benzoquinone Induced Apoptosis on MCF-7 Breast Cancer Cell Line

Authors : Hesti Lina Wiraswati, Pandji Irani Fianza, Toddy Prananda

Volume/Issue : Volume 4 - 2019, Issue 12 - December

Google Scholar : https://goo.gl/DF9R4u

Scribd : https://bit.ly/35reNcH

Drugs belonging Quinones group have been successfully explored for their anti-cancer activity (such as Adriamycin, mitoxantron, etc.) 1,4 Benzoquinone (BZQ) is an oxidative stress agent that belonging to this family. BZQ has been tested for its potential of anti-cancer in U2OS Osteosarcoma cell line but not MCF-7 Breast Cancer cell line. In the present study, the anti- cancer activity of BZQ on MCF-7 cancer cell lines were studied by MTT assay, Trypan blue assay and morphological analysis. The results showed that BZQ induced MCF-7 cell death. Further analysis showed that the type of the death is apoptosis which is time-dependent and dose- dependent. Further studies using antioxidants suggest the mechanism to induce apoptosis is by disrupting the antioxidant system. This results support the capacity of BZQ as a potent anti-cancer drug in therapeutic regimen.

Keywords : Cancer, MCF-7, 1,4-Benzoquinone, Oxidative Stress.


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