Authors :
Hesti Lina Wiraswati, Pandji Irani Fianza, Toddy Prananda
Volume/Issue :
Volume 4 - 2019, Issue 12 - December
Google Scholar :
https://goo.gl/DF9R4u
Scribd :
https://bit.ly/35reNcH
Abstract :
Drugs belonging Quinones group have been
successfully explored for their anti-cancer activity (such as
Adriamycin, mitoxantron, etc.) 1,4 Benzoquinone (BZQ)
is an oxidative stress agent that belonging to this family.
BZQ has been tested for its potential of anti-cancer in
U2OS Osteosarcoma cell line but not MCF-7 Breast
Cancer cell line. In the present study, the anti- cancer
activity of BZQ on MCF-7 cancer cell lines were studied
by MTT assay, Trypan blue assay and morphological
analysis. The results showed that BZQ induced MCF-7
cell death. Further analysis showed that the type of the
death is apoptosis which is time-dependent and dose-
dependent. Further studies using antioxidants suggest the
mechanism to induce apoptosis is by disrupting the
antioxidant system. This results support the capacity of
BZQ as a potent anti-cancer drug in therapeutic regimen.
Keywords :
Cancer, MCF-7, 1,4-Benzoquinone, Oxidative Stress.
Drugs belonging Quinones group have been
successfully explored for their anti-cancer activity (such as
Adriamycin, mitoxantron, etc.) 1,4 Benzoquinone (BZQ)
is an oxidative stress agent that belonging to this family.
BZQ has been tested for its potential of anti-cancer in
U2OS Osteosarcoma cell line but not MCF-7 Breast
Cancer cell line. In the present study, the anti- cancer
activity of BZQ on MCF-7 cancer cell lines were studied
by MTT assay, Trypan blue assay and morphological
analysis. The results showed that BZQ induced MCF-7
cell death. Further analysis showed that the type of the
death is apoptosis which is time-dependent and dose-
dependent. Further studies using antioxidants suggest the
mechanism to induce apoptosis is by disrupting the
antioxidant system. This results support the capacity of
BZQ as a potent anti-cancer drug in therapeutic regimen.
Keywords :
Cancer, MCF-7, 1,4-Benzoquinone, Oxidative Stress.
