Authors : Khushi Jadhav; Trupti Kadam; Pallavi Namdas; Anushka Guntapelliwar; Omkar Joshi

Volume/Issue : Volume 10 - 2025, Issue 2 - February

Google Scholar : https://tinyurl.com/47m98z5d

Scribd : https://tinyurl.com/4tzk8bep

DOI : https://doi.org/10.5281/zenodo.14917003

Abstract : Alzheimer's disease (AD), a progressive brain disorder, is the most common form of dementia, affecting memory, thought, and behavior. Despite extensive research, effective therapeutic treatments for AD and dementia remain elusive. This study analyzed select transcriptomic datasets to identify disease-associated proteins meeting specific criteria. We then docked these proteins with four existing AD drugs (Donepezil, Galantamine, Memantine, and Rivastigmine) and plant-derived actives from Thymus cilicius, Melissa officinalis, Salvia sclarea, Linum usitatissimum, and Curcuma longa. Notably, binding energy values for mutant proteins differed significantly from wild-type proteins, particularly in the MET proto-oncogene (PDB ID: 3ZXZ). Moreover, plant-derived actives exhibited higher relative stability values when docked with wild-type proteins compared to conventional drugs. Our findings suggest Alpha-Muurolene, Alpha-Atlantone, Alpha- Cadinene, Beta-Bourbonene, Beta-Cubebene, and Germacrene-D as promising alternative therapeutic candidates for Alzheimer's disease.[1,2,3,11,12,13]

Keywords : Alzheimer’s Disease, Dementia, Serotonergic Receptors, Auto Dock Vina.

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