Authors :
Sabin Yadav; Manash Chakraborty; Michalis Iosifidis; Haitham Abdelmoteleb
Volume/Issue :
Volume 10 - 2025, Issue 9 - September
Google Scholar :
https://tinyurl.com/yds6fuc7
Scribd :
https://tinyurl.com/4cmtcnxe
DOI :
https://doi.org/10.38124/ijisrt/25sep734
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Abstract :
Metastatic malignant melanoma involving the urinary bladder is an exceptionally rare finding. We report the case
of a man in his mid 70’s who initially presented with stroke-like symptoms. A CT head revealed multiple metastatic lesions
with no clear primary origin. Subsequent imaging of the chest, abdomen, and pelvis showed widespread metastases, with
lesions in the bladder raising suspicion of it being the primary site. Rigid cystoscopy and transurethral resection of bladder
tumour (TURBT) were performed, and histopathology confirmed malignant melanoma. Further investigation supported
the diagnosis of metastatic melanoma. The patient was started on corticosteroids, Encorafenib, and Binimetinib. Although
he initially responded well to treatment, his disease progressed both clinically and radiologically, and he sadly passed away
10 months after his initial presentation.
References :
- Sanchez JA, Robinson WA. Malignant Melanoma. Annu Rev Med. 1993;44:335-42. Doi: 10.1146/Annurev.Me.44.020193.002003. PMID: 8476254.
- Ahmed B, Qadir MI, Ghafoor S. Malignant Melanoma: Skin Cancer-Diagnosis, Prevention, And Treatment. Crit Rev Eukaryot Gene Expr. 2020;30(4):291-297. Doi: 10.1615/Critreveukaryotgeneexpr.2020028454. PMID: 32894659.
- Cancer Research UK Www.Cancerresearchuk.Org/Health-Professional/Cancer-Statistics/Statistics-By-Cancer-Type/Melanoma-Skin-Cancer#Heading-One. Accessed 03/03/2025
- Stein BS, Kendall AR. Malignant Melanoma Of The Genitourinary Tract. Journal Of Urology [Internet]. 1984 Nov 1 [Cited 2025 Mar 3];132(5):859–68. Available From: Https://Doi.Org/10.1016/S0022-5347(17)49927-7
- Anandrati M, Maini V, Asarian A, Xiao P. Metastasis Of Malignant Melanoma To The Urinary Bladder & Descending Colon: A Case Report And Literature Review. Urol Case Rep. 2024 Nov 7;57:102883. Doi: 10.1016/J.Eucr.2024.102883. PMID: 39583334; PMCID: PMC11585788.
- Boughaleb A, Kubiak M, Bourimi C, Tariqi R, Leroux PA, El Kentaoui H. Melanoma Metastasis To The Bladder: A Case Report Of An Underdiagnosed Entity. Int J Surg Case Rep. 2024 Sep;122:110048. Doi: 10.1016/J.Ijscr.2024.110048. Epub 2024 Jul 17. PMID: 39033701; PMCID: PMC11325074.
- Patil RV, Woldu SL, Lucas E, Quinn AM, Francis F, Margulis V. Metastatic Melanoma To The Bladder: Case Report And Review Of The Literature. Urol Case Rep. 2017 Jan 10;11:33-36. Doi: 10.1016/J.Eucr.2016.10.017. PMID: 28083484; PMCID: PMC5225280.
Metastatic malignant melanoma involving the urinary bladder is an exceptionally rare finding. We report the case
of a man in his mid 70’s who initially presented with stroke-like symptoms. A CT head revealed multiple metastatic lesions
with no clear primary origin. Subsequent imaging of the chest, abdomen, and pelvis showed widespread metastases, with
lesions in the bladder raising suspicion of it being the primary site. Rigid cystoscopy and transurethral resection of bladder
tumour (TURBT) were performed, and histopathology confirmed malignant melanoma. Further investigation supported
the diagnosis of metastatic melanoma. The patient was started on corticosteroids, Encorafenib, and Binimetinib. Although
he initially responded well to treatment, his disease progressed both clinically and radiologically, and he sadly passed away
10 months after his initial presentation.
