Intestines form a major part of human digestive system. Both in terms of length as well as surface area, the small and large intestinesconstitute about 90% of the digestive system. Intestines form a major part of human digestive system. One of the most common surgeries done on the intestines is resection and anastomosis. It is the surgical procedure of removing the diseased portion of the bowel and joining the normal viable disease free bowel ends.  Objective To identify patient and surgeon related intraoperative factors that affects the outcome of intestinal resection and anastomosis and predispose to anastomotic leak.  Method 50 cases requiring intestinal resection and anastomosis admitted in hospitals associated with Bangalore Medical College and research institute were selected after applying inclusion and exclusion criteria.  Conclusion Delay in presentation and aetiology ,End to side anastomosis and anastomosis between small bowel and large bowel has a higher risk for anastomotic leak