A Comparative Evaluation of Efficacy of Local Infiltration of Sodium Bicarbonate Buffered Local Anesthesia with Epinephrine Vs Non-Buffered La with Epinephrine: A Clinical Study


Authors : Dr. Amruta Chandra; Dr. Khalid A.; Dr. Ramank M.; Dr. Vivek P.; Dr. Pooja

Volume/Issue : Volume 9 - 2024, Issue 10 - October


Google Scholar : https://tinyurl.com/4p2wn4zu

Scribd : https://tinyurl.com/y3rm9m8c

DOI : https://doi.org/10.38124/ijisrt/IJISRT24OCT1574

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Background: The aim of the study was to compare the efficacy of local infiltration of sodium bicarbonate buffered local anaesthesia with epinephrine vs non- buffered local anaesthesia with epinephrine.  Method: Patients having periapical infection in the maxillary anterior and premolar region were selected for the study. A total of 50 patients were included in the study. In group A, 8.4% sodium bicarbonate buffered 2% Lignocaine with 1:80,000 adrenaline was used for local infiltration for extraction. In group B, 2% Lignocaine with 1:80,000 adrenaline (non-buffered) was used for local infiltration for extraction. The onset of anesthesia, was compared between group A and group B. Data was tabulated and statistical analysis was carried out using paired t-test.  Result: The inter-group difference in onset of anesthesia,was assessed using paired t-test and highly significant difference was found between group A and group B (p≤0.05).  Conclusion: Significant improvement seen in onset of anesthesia and duration of anesthesia.

Keywords : Buffered, Non-Buffered, Sodium Bicarbonate, Local Anesthesia, Pain, Duration.

References :

  1. Senthoor P, Janani K, Ravindran C. A prospective, randomized double-blinded study to evaluate the efficacy of buffered local anesthetics in infected and inflamed pulp and periapical tissues. Journal of maxillofacial and oral surgery. 2020 Jun;19(2):246-50.
  2. Arora G, Degala S, Dasukil S. Efficacy of buffered local anesthetics in head and neck infections. British Journal of Oral and Maxillofacial Surgery. 2019 Nov;57(9):857-60.
  3. Valiulla MU, Halli R, Khandelwal S, Mittal A, Singh A, Bhindora K, Khandelwal SG, Bhindora Jr K. Efficacy of Sodium Bicarbonate-Buffered Local Anesthetic Solution in Cases Requiring Bilateral Maxillary Premolar Orthodontic Extraction: A Comparative Split-Mouth Study. Cureus. 2023 Apr;15(4).
  4. Gupta S, Mandlik G, Padhye MN, Kini YK, Kakkar S, Hire AV. Combating inadequate anesthesia in periapical infections, with sodium bicarbonate: a clinical double blind study. Oral and maxillofacial surgery. 2014 Sep;18(3):325-9
  5. Malamed SF. Handbook of Local Anesthesia. 7th ed. St. Louis, Mo., USA: Mosby; 2019:16.
  6. Bokesch PM, Raymond SA, Strichartz GR. Dependence of lidocaine potency on pH and PCO2. Anesthesia & Analgesia. 1987 Jan 1;66(1):9-17.
  7. Condouris GA, Shakalis A. Potentiation of the nerve-depressant effect of local anaesthetics by carbon dioxide. Nature. 1964 Oct 3;204(4953):57-9.
  8. Wong K, Strichartz GR, Raymond SA. On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve. Anesthesia & Analgesia. 1993 Jan ;76(1):131-43.
  9. Fitton AR, Ragbir M, Milling MA. The use of pH adjusted lignocaine in controlling operative pain in the day surgery unit: a prospective, randomised trial. British journal of plastic surgery. 1996 Sep ;49(6):404-8.
  10. Davies RJ. Buffering the pain of local anaesthetics: a systematic review. Emergency Medicine. 2003 Feb;15(1):81-8.
  11. Erramouspe J. Buffering local anesthetic solutions with sodium bicarbonate: literature review and commentary. Hospital pharmacy. 1996;31(10):1275-82.
  12. Hanna MN, Elhassan A, Veloso PM, Lesley M, Lissauer J, Richman JM, Wu CL. Efficacy of bicarbonate in decreasing pain on intradermal injection of local anesthetics: a meta-analysis. Regional anesthesia and pain medicine. 2009 Mar 1;34(2):122.
  13. Primosch RE, Robinson L. Pain elicited during intraoral infiltration with buffered lidocaine. American journal of dentistry. 1996 Feb;9(1):5-10.
  14. Goodchild JH, Mark Donaldson BS. Novel direct injection chairside buffering technique for local anesthetic use in dentistry. Compendium. 2019 Jul;40(7).
  15. MUJTABA B, BRAIMAH RO. Buffering of Local Anaesthesia in Dentistry: A Review: Buffering of Local Anaesthesia in Dentistry. Nigerian Journal of Dental Research. 2023 Feb ;8(1):14-9.

Background: The aim of the study was to compare the efficacy of local infiltration of sodium bicarbonate buffered local anaesthesia with epinephrine vs non- buffered local anaesthesia with epinephrine.  Method: Patients having periapical infection in the maxillary anterior and premolar region were selected for the study. A total of 50 patients were included in the study. In group A, 8.4% sodium bicarbonate buffered 2% Lignocaine with 1:80,000 adrenaline was used for local infiltration for extraction. In group B, 2% Lignocaine with 1:80,000 adrenaline (non-buffered) was used for local infiltration for extraction. The onset of anesthesia, was compared between group A and group B. Data was tabulated and statistical analysis was carried out using paired t-test.  Result: The inter-group difference in onset of anesthesia,was assessed using paired t-test and highly significant difference was found between group A and group B (p≤0.05).  Conclusion: Significant improvement seen in onset of anesthesia and duration of anesthesia.

Keywords : Buffered, Non-Buffered, Sodium Bicarbonate, Local Anesthesia, Pain, Duration.

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