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A Comprehensive Ayurvedic Appraisement of Ulcerative Colitis: Pathophysiological Correlations and Management Strategies Via Purishavaha Sroto Dushti and Grahani Roga


Authors : Aswathy K. P.

Volume/Issue : Volume 11 - 2026, Issue 10 - October


Google Scholar : https://tinyurl.com/3fs3hhps

DOI : https://doi.org/10.38124/ijisrt/26Oct686

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Ulcerative Colitis (UC) is an idiopathic, chronic inflammatory bowel disease primarily affecting the colonic mucosa. Despite advancements in modern gastroenterology, long-term therapeutic management remains challenging due to adverse effects and high recurrence rates. In Ayurveda, the clinical features of UC characterized by bloody diarrhea, mucopurulent stools, and abdominal cramping closely align with the manifestations of Grahani Roga, Rakthatisara, and Purishavaha Sroto Dushti.This study aims to establish a holistic Ayurvedic conceptual framework (Samprapthi) for Ulcerative Colitis and outline a rationalized therapeutic protocol based on classical textual evidence.A comprehensive literary review was conducted utilizing classical Ayurvedic treatises (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, and Madhava Nidana) alongside contemporary clinical literature regarding the etiology, diagnosis, and pathology of Ulcerative Colitis. The analysis reveals that Ulcerative Colitis cannot be encapsulated by a single disease entity. Rather, it represents a complex Pitta-Raktadhika Sannipatha Roga occurring within a Vata Sthana (the colon). The foundational pathology originates from chronic Agni Mandhya (impaired metabolic fire) leading to Ama production, subsequent tissue damage (Rakta-Mamsa Dushti), and the formation of chronic ulcerations (Vrana) at the Moolasthana (roots) of the Purishavaha Srotas specifically the Pakwashaya (large intestine) and Sthula Guda (rectum). Effective management of Ulcerative Colitis necessitates a strict threefold approach: complete avoidance of causative factors (Nidana Parivarjana), deep metabolic correction combined with wound healing (Deepana-Pachana and Vrana Ropana), and adherence to a tailored, low-residue Pathya diet to arrest mucosal damage and promote systemic recovery.

Keywords : Grahani Roga, Purishavaha Srotas, Ulcerative Colitis, Rakthatisara.

References :

  1. Shastri K, Upadhyaya Y, editors. Charaka Samhita of Agnivesha, Chikitsa Sthana, Chapter 15 (Grahani Dosha Chikitsitam Adhyaya), Verses 55-57. 14th ed. Varanasi: Chaukhambha Sanskrit Sansthan; 2018.
  2. Shastri AD, editor. Sushruta Samhita of Sushruta, Sharira Sthana, Chapter 4 (Garbha Vyakarana Shariram), Verse 18. Varanasi: Chaukhambha Sanskrit Sansthan; 2017.
  3. Paradkar HSS, editor. Ashtanga Hridaya of Vagbhata, Chikitsa Sthana, Chapter 9 (Atisara Chikitsitam Adhyaya) and Chapter 8 (Grahani Dosa Chikitsitam Adhyaya). Varanasi: Chaukhambha Sanskrit Sansthan; 2014.
  4. Upadhyaya Y, editor. Madhava Nidana of Madhavakara, Part 1, Chapter 3 (Atisara Nidana) and Chapter 4 (Grahani Roga Nidana). Varanasi: Chaukhambha Prakashan; 2016.
  5. Tripathi B, editor. Chakradatta of Sri Chakrapanidatta, Grahani Chikitsa Adhyaya. Varanasi: Chaukhambha Sanskrit Sansthan; 2015.
  6. Singh SP, Kumar A, Rastogi S. Effects of Ayurvedic treatment on patients of Ulcerative Colitis. International Journal of Ayurvedic Medicine. 2021;12(3):412-419.
  7. Sharma V, Patel M, Gupta S. Ayurvedic Management of Ulcerative Colitis: A Clinical Case Study. Journal of Research in Ayurvedic Sciences. 2023;7(2):104-111.
  8. Joshi A, Kirti R, Sharma H. Pathophysiological Evaluation of Purishavaha Sroto Dushti in Relation to Inflammatory Bowel Disease. Ayushdhara: International Journal of Research in ISM. 2024;11(1):56-63.
  9. Ramadas K, Kumar NS. Remission in refractory Ulcerative Colitis (Aam-Raktaj Pravahika) with standalone Ayurveda intervention: A Case Report. Journal of Ayurveda and Integrative Medicine. 2025;16(4):100-106.
  10. Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 11th ed. Philadelphia: Elsevier Saunders; 2020.

Ulcerative Colitis (UC) is an idiopathic, chronic inflammatory bowel disease primarily affecting the colonic mucosa. Despite advancements in modern gastroenterology, long-term therapeutic management remains challenging due to adverse effects and high recurrence rates. In Ayurveda, the clinical features of UC characterized by bloody diarrhea, mucopurulent stools, and abdominal cramping closely align with the manifestations of Grahani Roga, Rakthatisara, and Purishavaha Sroto Dushti.This study aims to establish a holistic Ayurvedic conceptual framework (Samprapthi) for Ulcerative Colitis and outline a rationalized therapeutic protocol based on classical textual evidence.A comprehensive literary review was conducted utilizing classical Ayurvedic treatises (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, and Madhava Nidana) alongside contemporary clinical literature regarding the etiology, diagnosis, and pathology of Ulcerative Colitis. The analysis reveals that Ulcerative Colitis cannot be encapsulated by a single disease entity. Rather, it represents a complex Pitta-Raktadhika Sannipatha Roga occurring within a Vata Sthana (the colon). The foundational pathology originates from chronic Agni Mandhya (impaired metabolic fire) leading to Ama production, subsequent tissue damage (Rakta-Mamsa Dushti), and the formation of chronic ulcerations (Vrana) at the Moolasthana (roots) of the Purishavaha Srotas specifically the Pakwashaya (large intestine) and Sthula Guda (rectum). Effective management of Ulcerative Colitis necessitates a strict threefold approach: complete avoidance of causative factors (Nidana Parivarjana), deep metabolic correction combined with wound healing (Deepana-Pachana and Vrana Ropana), and adherence to a tailored, low-residue Pathya diet to arrest mucosal damage and promote systemic recovery.

Keywords : Grahani Roga, Purishavaha Srotas, Ulcerative Colitis, Rakthatisara.

Paper Submission Last Date
31 - October - 2026

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