A Comprehensive Review of the Evaluation of in Situ Gels


Authors : Somveer Singh; Ayush Gupta; Mohd. Adil Tahseen

Volume/Issue : Volume 9 - 2024, Issue 10 - October

Google Scholar : https://tinyurl.com/ymnz9hju

Scribd : https://tinyurl.com/589eedcp

DOI : https://doi.org/10.38124/ijisrt/IJISRT24OCT1075

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Abstract : In situ gels are now among the most widely used and widely available systems. These systems minimize drug administration frequency because of their special sol-to-gel transition properties, increasing patient comfort. Other benefits of these systems include easy production, improved adherence, and ease of use. 'Sol-gel' produces a colloidal suspension or solution by hydrolyzing the precursor and then polymerizing it through condensation. These in situ gelling techniques gel at the accomplishment site because they can be administered as solutions. Recently, several researchers developed liposomes, microspheres, nanoemulsions, nanospheres, and other in situ gelling systems. One of the greatest innovative drug delivery methods to date is the "in situ gel" system, which promotes better patient comfort and compliance as well as a prolonged and regulated release of the medication. With in situ gel formation, a variety of natural and synthetic polymers may find application in oral, ophthalmic, transdermal, buccal, intraperitoneal, parenteral, injectable, rectal, and vaginal routes. Research on the in-situ gel system has a lot of potential to offer cutting-edge methods for medication delivery systems.

Keywords : In Situ Gels, Sol-Gel, Polymers, Innovative Drug Delivery, Patient Comfort.

References :

  1. Maryam Kouchak In Situ Gelling Systems for Drug Delivery Jundishapur J Nat Pharm Prod. 2014; 9(3): 20126.
  2. Padmasri Budumuru, Ravouru Nagaraju, Damarasingu Prasanth A comprehensive review on in situ gels International Journal of Applied Pharmaceutics 2020;12(6):24-33
  3. Mounika Konatham, Mounika Tejaswi Gorle, Naveen Pathakala, Vasudha Bakshi, Yaso Deepika Mamidisetti, Priyanka Chinthakindi, Rajendra Kumar Jadi In Situ Gel Polymers: A Review Int J App Pharm. 2021; 13 (1): 86-90
  4. M. Madan, A. Bajaj, S. Lewis, N. Udupa, J. A. Baig In Situ Forming Polymeric Drug Delivery Systems Indian J Pharm Sci. 2009; 71(3): 242–251.
  5. Shailaja Pashikanti, Jyothsna B Formulation and evaluation of floating in situ gel of ciprofloxacin Int J App Pharm. 2019; 11 (1): 198-204
  6. Vishwa J. Kalaria, S. Saisivam, Anas Alshishani, Jameel S. Aljariri Alhesan, Sumit Chakraborty, Mohamed Rahamathulla Design and evaluation of in situ gel eye drops containing nanoparticles of Gemifloxacin Mesylate Drug Delivery 2023; 30 (1): 2185180
  7. Deepika Joshi, Praveen Kumar, Sakshi Nainwal Ophthalmic formulation and evaluation of ofloxacin in- situ gel World Journal of Pharmacy and Pharmaceutical Sciences 2020; 9 (11): 1906-1918
  8. Dasharath M. Patel, Divyesh K. Patel, Chhagan N. Patel Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin ISRN Pharm. 2011; 2011: 276250.
  9. Tiraniti Chuenbarn, Jitnapa Sirirak, Sarun Tuntarawongsa, Siriporn Okonogi, Thawatchai Phaechamud Design and Comparative Evaluation of Vancomycin HCl-Loaded Rosin-Based In Situ Forming Gel and Microparticles Gels. 2022; 8(4): 231.
  10. Jinal Patel, Panchaxari Dandagi, Sujay Hulyalkar and Bapu Desai Formulation And Evaluation Of Oral Floating In Situ Gel Of Cefixime Trihydrate By Using β-Cyclodextrin Complexation Technique For Solubility Enhancement World Journal Of Pharmacy And Pharmaceutical Sciences 2020; 9 (10): 2613-2625
  11. Satyajit Sahoo, Kirti Malviya, Nishant Oza, Anirud Solanki, Prasanta Kumar Mohapatra Formulation And Evaluation Of Sustained Release In-Situ Gel Of Amikacin By Using 32 Full Factorial Design IJPSR 2020; 11(7): 3333-3346.
  12. Al-Joufi, F.; Elmowafy, M.; Alruwaili, N.K.; Alharbi, K.S.; Shalaby, K.; Alsharari, S.D.; Ali, H.M. Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity. Pharmaceutics 2021; 13: 336.
  13. Kexin Sun,Ke Hu Preparation and Characterization of Tacrolimus-Loaded SLNs in situ Gel for Ocular Drug Delivery for the Treatment of Immune Conjunctivitis Drug Des Devel Ther. 2021; 15: 141–150.
  14. Eleonora Terreni, Erica Zucchetti, Silvia Tampucci, Susi Burgalassi, Daniela Monti, Patrizia Chetoni Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System (ODDS) for Cyclosporine-A Pharmaceutics. 2021; 13(2): 192.
  15. Monowar Hussain Temperature triggered in-situ gelling system for ocular antiviral drug IJPSR 2021; 12(1): 281-291
  16. Nagendra R., Roopa S. Pai, Gurinder Singh Design and optimization of novel in situ gel of mercaptopurine for sustained drug delivery Brazilian Journal of Pharmaceutical Sciences 2014; 50 (1): 107-119
  17. Sara S. Barakat, Maha Nasr, Rania F. Ahmed, Sabry S. Badawy, Samar Mansour Intranasally administered in situ gelling nanocomposite system of dimenhydrinate: preparation, characterization and pharmacodynamic applicability in chemotherapy-induced emesis model Scientific Reports 2017; 7: 9910
  18. Madhugiri Prakash Venkatesh, Tegginmat Pramod Kumar, Deeksha Ramananda Pai Targeted drug delivery of Methotrexate in situ gels for the treatment of Rheumatoid Arthritis Saudi Pharmaceutical Journal 2020; 28 (12): 1548-1557
  19. Bai-Yi Yan, Bai-Lu Liu, Ling-Yu Yi, Gui-Ling Wang, Bai-Zhong Xue, Ying Xie Doxorubicin-Loaded In Situ Gel Combined with Biocompatible Hydroxyethyl Cellulose Hemostatic Gauze for Controlled Release of Drugs and Prevention of Breast Cancer Recurrence Post-surgery Biomaterials Science & Engineering 2020; 6(10):5959-5968
  20. Kevin Garala, Parth Joshi, Malay Shah, A Ramkishan, Jaydeep Patel Formulation and evaluation of periodontal in situ gel International Journal of Pharmaceutical Investigation | 2013; 3 (1): 29-41
  21. Viliana Gugleva, Victoria Michailova, Rositsa Mihaylova, Georgi Momekov, Maya Margaritova Zaharieva, Hristo Najdenski, Petar Petrov, Stanislav Rangelov, Aleksander Forys, Barbara Trzebicka, Denitsa Momekova Formulation and Evaluation of Hybrid Niosomal In Situ Gel for Intravesical Co-Delivery of Curcumin and Gentamicin Sulfate Pharmaceutics. 2022; 14(4): 747.
  22. Khaled M. Hosny, Waleed Y. Rizg, Hala M. Alkhalidi, Walaa A. Abualsunun, Rana B. Bakhaidar, Alshaimaa M. Almehmady, Adel F. Alghaith, Sultan Alshehri, Amani M. El Sisi Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment Drug Delivery 2021; 28 (1): 1836–1848
  23. Ei Mon Khaing, Torsak Intaraphairot, Jongjan Mahadlek, Siriporn Okonogi, Wiwat Pichayakorn, Thawatchai Phaechamud Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells Gels. 2022; 8(9): 526.
  24. Kulwant Singh, Harpreet Kaur, S. L. Hari Kumar Design and development of sustained release injectable in situ gel of cytarabine Pharmacophore 2013; 4 (6): 252-267
  25. Surendra Singh Saurabh, Kamal Singh Rathore, Santanu Ghosh Formulation and evaluation of cetirizine hydrochloride pH trigged in-situ ocular gel Int J App Pharm. 2023;15 (2):106-116
  26. Tadavi SA, Pawar SP. Development of Nasal In-situ Gel Formulation of Fexofenadine HCl Using Gellan Gum (Gelerite®). International Journal of Pharmaceutical Quality Assurance. 2023;14(1):1-3.
  27. Rohan Chhabra, K. Mahalingan, A Geethalakshmi, Pynskhemlin Syiemlieh Formulation and Evaluation of Rabeprazole Oral Floating In-Situ Gel Archives of Pharmaceutical Sciences and Research 2023; 13 (1): 122-131
  28. Rençber S, Özcan Bülbül E, Üstündağ Okur N, Ay Şenyiğit Z. Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application. J Res Pharm. 2021; 25(1): 1-12.
  29. Patel P, Patel P. Formulation and evaluation of clindamycin HCl in situ gel for vaginal application. Int J Pharma Investig 2015; 5: 50-6.
  30. Sanjana A, Mohammed Gulzar Ahmed, Jaswanth Gowda BH Preparation and evaluation of in-situ gels containing hydrocortisone for the treatment of aphthous ulcer Journal of Oral Biology and Craniofacial Research 2021;11: 269–276
  31. Gyan Mohan, Sandeep K. Singh, Mary Koshy, Pooja Chawla, Koshy M. Kymonil Nasal mucoadhesive thermoreversible in situ gel of phenytoin sodium for epilepsy Pharmaspire 2020;12 (3): 96-99
  32. Sonali A. Nagare, Jeevan R. Rajguru, Vikas G. Rajurkar, and Mrunal K. Shirsat Development and Evaluation of Nasal Mucoadhesive in Situ Gel Formulations of Carbamazepine Using In Vitro, Ex-Vivo and In-Vivo Methods International Research Journal of Pharmacy and Medical Sciences 2018;1 (6): 69-75
  33. Rathapon Asasutjarit, Suthira Thanasanchokpibull, Asira Fuongfuchat, Sukitaya Veeranondha Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels International Journal of Pharmaceutics 2011; 411:128–135
  34. Balaji Maddiboyina, Arthapu Hari Krishna, Makkena Ramya Sri, Pasupuleti Bhuvana Kalyani, Shaik Jabeena, Shaik Sharmila, Vankudavatu Lakshmibai Preparation and evaluation of ibuprofen in-situ periodontal gel Int. J. of Allied Med. Sci. and Clin. Research 2020; 8(1): 67-75
  35. Tingting Li, Quanying Bao, Jie Shen, Rajesh V. Lalla, Diane J. Burgess Mucoadhesive in situ forming gel for oral mucositis pain control International Journal of Pharmaceutics 2020; 580: 119238

In situ gels are now among the most widely used and widely available systems. These systems minimize drug administration frequency because of their special sol-to-gel transition properties, increasing patient comfort. Other benefits of these systems include easy production, improved adherence, and ease of use. 'Sol-gel' produces a colloidal suspension or solution by hydrolyzing the precursor and then polymerizing it through condensation. These in situ gelling techniques gel at the accomplishment site because they can be administered as solutions. Recently, several researchers developed liposomes, microspheres, nanoemulsions, nanospheres, and other in situ gelling systems. One of the greatest innovative drug delivery methods to date is the "in situ gel" system, which promotes better patient comfort and compliance as well as a prolonged and regulated release of the medication. With in situ gel formation, a variety of natural and synthetic polymers may find application in oral, ophthalmic, transdermal, buccal, intraperitoneal, parenteral, injectable, rectal, and vaginal routes. Research on the in-situ gel system has a lot of potential to offer cutting-edge methods for medication delivery systems.

Keywords : In Situ Gels, Sol-Gel, Polymers, Innovative Drug Delivery, Patient Comfort.

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