Authors :
Oboro, Enifome; Akazue, Maureen
Volume/Issue :
Volume 10 - 2025, Issue 8 - August
Google Scholar :
https://tinyurl.com/4r66cxd6
Scribd :
https://tinyurl.com/43mfa8wn
DOI :
https://doi.org/10.38124/ijisrt/25aug280
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Note : Google Scholar may take 30 to 40 days to display the article.
Abstract :
Diabetic retinopathy, glaucoma, Central Serous Retinopathy (CSR), age-related macular degeneration (AMD),
and retinitis are primary causes of visual diseases worldwide. As such, several types of retinal disease predictive or
diagnostic models are designed to prevent vision loss or impairment. Since correct prediction is crucial for treatment, a
survey of existing retinal disease predictive or diagnostic models was conducted, and algorithms used to predict retinal
disease were analyzed. The survey showed that despite improvements with the incorporation of machine learning, many
automated retinal disease diagnosis systems still rely heavily on traditional models for classification tasks. Thus, limiting
the retinal disease SVM models’ performance in handling complex, high-dimensional retinal images. Therefore, this study
incorporates a Convolutional Neural Network-based framework to directly learn discriminative features from raw retinal
images without manual intervention to predict kinds of retinal diseases. In the future, the efficiency of this approach will
be demonstrated by developing and implementing a CNN-based retinal disease predictive system for diabetic retinopathy,
glaucoma, CSR, AMD, and retinitis, and evaluating it for real-world clinical use.
Keywords :
Retinitis, Central Serous Retinopathy, Retinal Diseases, Machine Learning, Convolutional Neural Network.
References :
- Kumar, A.S. Tewari, J.P. Singh, Classification of diabetic macular edema severity using deep learning technique. Res. Biomed. Eng. Vol 38, pp 977–987, 2022
- Maureen, E.K. Henry, C. Asuai, Application of RFM model on Customer Segmentation in Digital Marketing. Nigerian Journal of Science and Environment, vol 22, No 1, 2024, 57–67. https://doi.org/10.61448/njse221245
- M. D. Okpor, F. O. Aghware, M. I. Akazue, A. A. Ojugo, F. U. Emordi, C. C. Odiakaose, R. E. Ako, V. O. Geteloma, A. P. Binitie, P. O. Ejeh, Comparative Data Resample to Predict Subscription Services Attrition Using Tree-based Ensembles, Journal of Fuzzy Systems and Control, vol. 2, no 2, 2024, 117-124, DOI: 10.59247/jfsc.v2i2.213
- A.I Maureen and A.I Ben, “Fuzzy based enhanced smart rest room automated faucet system”, I.J. Engineering and Manufacturing., vol. 3, 2017, pp 20-30
- M. Akazue and B. Ojeme, "Building Data Mining For Phone Business", Oriental journal of computer science and technology: An international open access peer reviewed research journal, vol. 7, no. 03, 2014, pp. 316-322
- U.K Okpeki and E.U. Omede, Design and implementation of auto tech resource sharing system for secondary schools in delta state. Journal of the Nigerian Association of Mathematical Physics, vol. 51, 2019, pp 325 – 332
- M. Akazue, B. Ojeme, NO Ogini, User interface adaptability for all users International Journal of Natural and Applied Sciences, vol. 6, issue 1, 2010
- A.A. Ojugo and A.O. Eboka, “Empirical evidence of socially-engineered attack menace among undergraduate smartphone users in selected Universities in Nigeria,” International Journal of Advanced Trends in Computer Science and Engineering, vol. 10, no. 3, 2021, pp.2103–2108
- M. I. Akazue, A. Aghaulor, B. I. Ajenaghughrure, Customer’s Protection in Ecommerce Transactions Through Identifying Fake Online Stores CSREA Press, 2015 World Congress in Computer Science, Computer Engineering, and Applied Computing, July 27th – 30th, Nevada, USA, pp 52-54
- A.A, Ojugo and D.O. Otakore, Intelligent cluster connectionist recommender system using implicit graph friendship algorithm for social networks, Int. Journal of Artificial Intelligence, vol 9, issue 3, 2020, pp497~506, doi: 10.11591/ijai.v9.i3.pp497~506
- U. K. Okpeki, S. A. Adegoke, and E.U. Omede. Application of Artificial Intelligence for Facial Accreditation of Officials and Students for Examinations. FUPRE Journal of Scientific and Industrial Research. Vol. 6, no. 3, 2022, pp01 – 11
- M. Akazue, and A. Aghaulor, Identification of Cloned Payment Page in Ecommerce Transaction. International Management Review, vol. 11, no. 2, 2015, 70-76.
- S.N. Okofu, C. Asuai, O. Okumoku-Evroro, and M. I. Akazue, Development of an Enhanced Point of Sales System for Retail Business in Developing Countries. Journal of Behavioural Informatics, Digital Humanities and Development Rese vol. 11 no. 5. 2025, Pp 1-24. https://www.isteams.net/behavioralinformaticsjournal dx.doi.org/10.22624/AIMS/BHI/V11N1P1
- S.N. Okofu, The impact of cash scarcity on adoption of banking technology by consumers in Delta State, Journal of Social and Management Sciences. vol. 18, no.1, 2023, pp 15 – 28
- M. I.. Akazue, A Survey of Ecommerce Transaction Fraud Prevention Models. In The Proceedings of the International Conference on Digital Information Processing, Data Mining, and Wireless Communications, Dubai, UAE. 2015, pp 140-146
- A. Ojugo and A. O. Eboka, “Memetic algorithm for short messaging service spam filter using text normalization and semantic approach,” International Journal of Informatics and Communication Technology (IJ-ICT), vol. 9, no. 1, 2020, pp. 9–18, Apr. 202 doi: 10.11591/ijict.v9i1.pp9-18.
- N.F. Efozia, S. O. Anigbogu, and K. S..Anigbogu, Development of a hybrid model for enhancing data integration process of business intelligence system. Journal of Basic Physical Research vol. 9., no. 2., 2019, pp 1-16
- E.I. Ihama, M.I. Akazue, E. Omede, D. Ojie, A Framework for Smart City Model Enabled by Internet of Things (IoT). International Journal of Computer Applications (0975 – 8887) vol.185, no.6,2023, pp 6-11
- E.I. Ihama, M.I. Akazue., K. O. OBAHIAGBON, A Survey of Smart City Development and the Role of Internet of Things, FUPRE Journal of Scientific and Industrial Research, vol. 9, no. 1, 2025a, pp 28-37
- M. Akazue, C.U. Agwi, and I.B. Ajenaghughrure, I. B (2017). The interlink between rfid of things and internet of domestic things. sau Science-Tech Journal, vol. 2, no.1, 2017, pp 92-101
- S. Okofu, E. K. Anazia, M. Akazue, C. Ogeh, and I. B. Ajenaghughrure, The Interplay Between Trust In Human-Like Technologies And Integral Emotions: Google Assistant. Kongzhi yu Juece/Control and Decision, vol. 38, Issue 01, 2023, pp 809-828
- S. N. Okofu, Users Service Quality Trust Perception of Online Hotel Room Reservation. SAU Journal of Management and Social Sciences,vol 3, no.1 & 2, 2018, pp 1-14
- M. I. Akazue, Users’ Perception in an Intelligent Automatic Fire Detection System for Developing Countries. Journal of Computer Science and its Applications vol 24, no.2, 2017, pp 111 -119
- M. I. Akazue, A fuzzy based intelligent irrigation system. Science-Tech Journal, vol.1, no.1, 2016, pp12-2
- S. N. Okofu, T. Anning-Dorson, and H. I. Duh Consumer Adoption and Continual Use of E-Vouchers: A Study of the Nigeria Telecommunication, International Research Journal of Multidisciplinary Scope, vol. 06, no. 02, 2025, pp. 330-342, DOI:10.47857/irjms.2025.v06i02.03788
- S. N. Okofu, J. Bisina,O. Okumoku-Evroro, and M. I. Akazue, Cash on delivery risk mitigation CMRR model, Journal of the Management Sciences, vol. 61, no. 9, 2024, pp 142 – 155
- M. I. Akazue, G. E. Izakpa, C. O. Ogeh, E. Ufiofio, A secured computer based test system with resumption capability module. Kongzhi yu Juece/Control and Decision, vol. 38, issue 02, May, 2023, pp 893 – 904
- O. G. Mega, M. I. Akazue, O. Z. Apene, and J. A. Hampo, 2024). Adoption of Blockchain Technology Framework for Addressing Counterfeit Drugs Circulation. European Journal of Medical and Health Research, vol. 2, no. 2, pp 182-196.
- T. Dio, M. I. Akazue, S. N. Okofu, Development of an Online Examination Monitoring System using Zoom, International Journal of Computer Applications, vol. 185, no. 40, 2023, pp 1 -10
- O. C. Ikem, M. I. Akazue, Data misuse and theft protection model in internet of things devices, Scientia Africana, vol. 24, no. 2, 2025, pp 277-282
- D. Ojie, M. Akazue, and A. Imianvan, A Framework for Feature Selection using Data Value Metric and Genetic Algorithm, International Journal of Computer Applications, Vol. 184, Issue 43, 2023, pp 14-21, doi:10.5120/ijca2023922533
- R. E. Yoro, M. D. Okpor, M.I. Akazue, E.A. Okpako, A. O. Eboka, P.O. Ejeh, et al., Adaptive DDoS detection mode in software defined SIP-VoIP using transfer learning with boosted meta-learner. PLoS One vol. 20, no. 6, 2025, pp 1-20, https://doi.org/10.1371/journal. pone.0326571
- F. O. Aghware, M. I., Akazue, M. D. Okpor, B. O. Malasowe, T. C. Aghaunor, E. V. Ugbotu, A. A. Ojugo, R. E. Ako, V. O. Geteloma, C. C. Odiakaose, A. O. Eboka, and S. I. Onyemenem, 2025). Effects of Data Balancing in Diabetes Mellitus Detection: A Comparative XGBoost and Random Forest Learning Approach . NIPES - Journal of Science and Technology Research, vol. 7, no. 1, 2025, PP 1–11. https://doi.org/10.37933/nipes/7.1.2025
- G. Litjens, T. Kooi, B. E. Bejnordi, A. A. Setio, F. Ciompi, M. Ghafoorian, and B. Ginneken, (2017). A survey on deep learning in medical image Medical Image Analysis, vol. 42, pp 60-88. challenges. Journal of Medical Imaging, vol. 28, no. 3, 2017, pp 246-260. https://doi.org/10.1111/jmi.12345
- D. S. W. Ting, L. R. Pasquale, L. Peng, J. P. Campbell, A. Y. Lee, R. Raman, and T. Y. Wong, Artificial intelligence and deep learning in ophthalmology. British Journal of Ophthalmology, vol. 103, no. 2, 2019, pp 167–175
- M.I. Akazue, O. Ovoh, A. Edje, O. Clement, and J. Hampo, An enhanced model for the prediction of Central Serous Retinopathy using bagging techniques. Journal of Healthcare Research, vol. 8, 2023, pp 220–227.
- M. I. Akazue, C Ekpewu, E. Omede, A. E. Edje. Development of a Semantic Web Framework for the Blind, International Journal of Innovative Science and Research Technology, Volume 8, Issue 1, January– 2023, pp 1781 – 1789
- X. Li, Y. Wu, and W. Zhang,Deep learning applications in retinal image analysis for disease diagnosis. Journal of Medical Systems, vol. 44, no. 8, 2020, pp 123.
- M. Abeer, M. Ali, and Z. Ahmad, Retina diseases diagnosis using deep learning. Journal of Medical Imaging, vol. 15, no. 3, 2022, pp 134-142.
- C N., Arpitha, N. Revani, P. Archana, T.M. Kavya. SVM based CSR disease detection for OCT and Fundus Imaging. M.Tech. Scholar, CS&E Department, Adichunchanagiri Institute of Technology Chikamagaluru, India. Vol. 10 Issue 08. 2023, pp.385 390
- Amit, S. Ahlawat, S. Urooj, N. Pathak, A. Lay-Ekuakille, and N. Sharma, 2023). A deep learning-based framework for retinal disease classification. Healthcare, vol. 11, no. 2, 2023, pp 212
- L. Stwart, and G. Sterestina, Retinal disease detection using deep learning techniques: A comprehensive review. Journal of Ophthalmology and Vision Science, vol. 12, no. 4, 2023, pp 223-234
- Amit, A., Balla, A., and Johnson, P. (2023). Advances in retinal disease detection using deep learning algorithms. Journal of Medical Imaging Research, 42(4), 456-468
- J. Ayesha, S. Naseem, J. Li, T. Mahmood, M.K. Jabbar, A. Rehman, and T. Saba, Diabetic retinopathy detection using retinal fundus images in remote areas. Scientific Reports, vol. 17, 2024, pp 135
- S. Ahmed, M. Khan, and R. Ali, 2024). Review of eye diseases detection and classification using deep learning techniques. Journal of Medical Imaging and Health Informatics, vol. 15, no. 2, 2024, pp 112-126
- Goutam, M. F. Hashmi, Z. W. Geem, and N.D. Bokde, A comprehensive review of deep learning strategies in retinal disease diagnosis using fundus images. IEEE Access, vol. 10, 2022, pp 57796-57823
- S. A. Barman, and M. Al-Mahmud, A comprehensive survey on deep learning in medical image analysis for retinal disease detection. Medical Image Analysis, vol. 69, 2021
- M. E. H. Chowdhury and N. Sultana, Deep learning-based classification and segmentation of retinal diseases using optical coherence tomography. Healthcare, vol. 8, no. 2, 2020, pp 129
- M. A. Farooq, and M. Abdullah, Deep learning for medical image analysis: A survey. Artificial Intelligence in Medicine, vol. 95, 2019, pp 90-99
- J. A. García and J. M. Ruiz, Deep learning for diabetic retinopathy detection: A systematic review. Journal of Ophthalmology, 2021, pp 1-15
- A. González and A. F. López, Early diagnosis of diabetic retinopathy using deep learning methods: Challenges and solutions. Computers in Biology and Medicine, 2022, pp 144
- J. Hu and Y. Zheng, A deep learning-based approach for the detection of macular degeneration. Biomedical Signal Processing and Control, 2021, pp 63
- A. Aslam, S. Farhan, M. A. Khaliq, F. Anjum, A. Afzaal and F. Kanwal, 2023). Convolutional neural network based classification of multiple retinal diseases using fundus images. Intelligent Automation and Soft Computing, vol. 36, no. 3, 2023, pp 2607–2622
- M. S. Islam, and J. Wang, A survey on retinal disease detection using deep learning algorithms. International Journal of Computer Vision, vol. 128, no. 2, 2019, pp 174-190
- M. Madbouly, F. Mohamed and A. Amer, Deep learning models for retinal disease detection. Journal of Healthcare Informatics Research, vol. 5, no. 3, 2020, pp 234-245.
- Y. Cheng, Y. Zhang and H. Xu, Convolutional neural networks for retinal image classification: A survey. IEEE Transactions on Medical Imaging, vol. 37, no. 7, 2018, pp 1580-1596
- F. Liu, M. and Zhang, A deep convolutional neural network-based approach for early diagnosis of retinal diseases. IEEE Access, vol. 7, 2019, pp 65053-65062
- H. Luo and Y. Zhang, 2020). Retinal disease detection using deep learning algorithms and OCT images: A review. Journal of Ophthalmology and Vision Science, vol. 41, no. 3, 2020, pp 242-256
- J. H. Min, and J. H. Jeong. (2021). Deep learning in ophthalmology: Applications and challenges. Journal of Medical Imaging, vol. 28, no. 6, 2021, pp 497-505
- G. Muhammad and M. Z. Afzal, Deep learning methods for the analysis of retinal images in diabetic retinopathy: A systematic review. Health Information Science and Systems, vol. 9, no. 1, 2021, pp 21
- S. Wang and L. Zhou, Convolutional neural networks for retinal disease diagnosis: Applications and challenges. Journal of Biomedical Optics, vol. 25, no. 4, 2020, pp 1-8
- S. Patel and V. Mistry, 2019). Review of deep learning techniques for early detection of retinal diseases. Journal of Biomedical Science and Engineering, vol. 12, no. 1, 2019, pp 58-74
- J. Song and H. Yu, Deep learning for early diagnosis of retinal diseases: A survey. Pattern Recognition, vol. 112, 2022
- K. Roy and P. Singh, Deep learning applications for retinal disease detection: A systematic review. Journal of Optical Society of America A, vol. 38, no. 4, 2021, pp 709-719
- S. Saxena and D. Hegde, A review on computer-aided diagnosis for retinal diseases using deep learning. Journal of Healthcare Engineering, 2020, pp 1-13
- S. Li and Q. Wang, Automated detection of diabetic retinopathy in retinal fundus images: A review of deep learning-based methods. Medical Image Analysis, vol. 51, 2018, pp 131-146
- S., Mankar, and N. Rout, Automatic detection of diabetic retinopathy using morphological operation and machine learning. ABHIYANTRIKI Int. J. Eng. Technol, vol. 3, no. 5, 2016, 12-19
- Mohamed and M. Marwa, Deep learning-based classification of eye diseases using convolutional neural networks for OCT images. Frontiers in Computer Science, vol. 5, 2024
- Abdillah, A. Bustamam and D. Sarwinda, Classification of diabetic retinopathy through texture features analysis. In Advanced Computer Science and Information Systems (ICACSIS), 2017 International Conference on IEEE, pp. 333-338
- S. Megala, T. S. and Subashini, (2020). An automated multi-retinal disease classification model using machine learning techniques. International Journal of Advanced Research in Engineering and Technology (IJARET), vol. 11. No. 11, 2020, pp 937–958
- T. D. Nguyen, D.T. Le, J. Bum, S. Kim, S. J. Song and H. Choo, Retinal disease diagnosis using deep learning on ultra-wide-field fundus images. Diagnostics, vol. 14, no. 1, 2024, pp 105
- R. Chavan and D. Pete, Automatic multi-disease classification on retinal images using multilevel glowworm swarm convolutional neural network. Journal of Engineering and Applied Science, vol. 71, no. 2, 2024
- N. G. Barai, S. Banik and F. M. J. M. Shamrat, A novel fusion deep learning approach for retinal disease diagnosis enhanced by web application predictive tool. International Journal of Advanced Computer Science and Applications (IJACSA), vol. 14, no. 12, 2023, pp 704–712
- A. Rakib, M/ M. Billah, A. S. Ahamed, H. M. Imamul and M. S. A. Masum, EfficientNet-based model for automated classification of retinal diseases using fundus images. European Journal of Computer Science and Information Technology, vol. 12, no. 8, 2024, pp 48-61
- N. T. Rao, M. Siddique, K. S. Kishore, K. I. Reddy and P. V. Anurag, Retinal disease prediction using machine learning. International Research Journal of Modernization in Engineering, Technology and Science, vol. 7, no. 3, 2025, pp 11828–11835.
- A. Mohammad, A., M. Z. Utso, S. B. Habib and A. K. Das, (2021). Predicting retinal diseases using efficient image processing and convolutional neural network (CNN). Journal of Engineering Advancements, vol. 2, no. 4, 2021, pp 221–227
- S. Sorrentino, L. Gardini, L. Fontana, M. Musa, A. Gabai, A. Maniaci, S. Lavalle, F. D’Esposito, A. Russo, A. Longo, P. L. Surico, C. Gagliano and M. Zeppieri, M. (2024). Novel approaches for early detection of retinal diseases using artificial intelligence. Journal of Clinical Medicine, vol. 13, no. 1, 2024, pp 42
- Maureen, O. Ovoh, A. Edje, O.\ Clement and J. Hampo, An enhanced model for the prediction of Central Serous Retinopathy using bagging techniques. Journal of Healthcare Research, vol. 8, 2023, pp 220–227
- Mohamed, Deep learning-based classification of eye diseases using convolutional neural networks for OCT images. Frontiers in Computer Science, vol. 5, 2024
- Goutam, M. F. Hashmi, Z. W. Geem and N. D. Bokde, A comprehensive review of deep learning strategies in retinal disease diagnosis using fundus images. IEEE Access, vol. 10, 2022, pp 57796-57823
- Y. Wang, W. Zuo and J. Zhang, Bias in deep learning for medical imaging: Challenges and solutions. IEEE Transactions on Medical Imaging, vol. 43, no. 2, 2023, pp 230-239
- R. Kumar, P. Sharma, S. Gupta and A. Singh, Deep learning approaches for automated retinal disease detection: Challenges and future directions. International Journal of Ophthalmic Research, vol. 16, no. 1, 2024, pp 45-56
- X. Li, Y. Wu and W. Zhang, Deep learning applications in retinal image analysis for disease diagnosis. Journal of Medical Systems, 44, no. 8, 2020, pp 123
Diabetic retinopathy, glaucoma, Central Serous Retinopathy (CSR), age-related macular degeneration (AMD),
and retinitis are primary causes of visual diseases worldwide. As such, several types of retinal disease predictive or
diagnostic models are designed to prevent vision loss or impairment. Since correct prediction is crucial for treatment, a
survey of existing retinal disease predictive or diagnostic models was conducted, and algorithms used to predict retinal
disease were analyzed. The survey showed that despite improvements with the incorporation of machine learning, many
automated retinal disease diagnosis systems still rely heavily on traditional models for classification tasks. Thus, limiting
the retinal disease SVM models’ performance in handling complex, high-dimensional retinal images. Therefore, this study
incorporates a Convolutional Neural Network-based framework to directly learn discriminative features from raw retinal
images without manual intervention to predict kinds of retinal diseases. In the future, the efficiency of this approach will
be demonstrated by developing and implementing a CNN-based retinal disease predictive system for diabetic retinopathy,
glaucoma, CSR, AMD, and retinitis, and evaluating it for real-world clinical use.
Keywords :
Retinitis, Central Serous Retinopathy, Retinal Diseases, Machine Learning, Convolutional Neural Network.