Authors :
Dr. Asmae Bentaleb; Hounaida Mahfoud; Rim Laaboudi; Mohamed Elkhorassani; Rajae Tachinante; Mounia Yousfi; Fatima Elhasouni
Volume/Issue :
Volume 10 - 2025, Issue 8 - August
Google Scholar :
https://tinyurl.com/579a2zw6
Scribd :
https://tinyurl.com/ycx4su7r
DOI :
https://doi.org/10.38124/ijisrt/25aug1024
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Abstract :
Von Willebrand disease (VWD), the most common inherited bleeding disorder, is classified into types 1, 2, and 3.
Women with VWD are at higher risk of bleeding during menstruation, childbirth, and postpartum.
This case of a 24-year-old pregnant woman with VWD underscores the importance of early management to prevent
postpartum hemorrhage. Desmopressin and VWF infusion enabled a successful cesarean and uneventful recovery.
Diagnosis relies on VWF and FVIII assays, and prophylactic treatment is advised during pregnancy. Vaginal delivery
without instrumentation is preferred, with cesarean reserved for obstetric reasons.
Keywords :
Von Willebrand Disease, Deficiency, Haemorrhage, Pregnancy.
References :
- Khallikane S, Moutaoukil M, Delsa HJP-CM. Maladie de Willebrand Type 1, grossesse, accouchement et hématome rétroplacentaire: à propos d´ un cas. 2021;6(11).
- Munoz Vargas BA, Contreras Valero SJ, Aragon Mendoza RL, Gallo Roa R, Enciso Olivera LJ. Von Willebrand Disease and Pregnancy: Management Protocol From Labor to the Postpartum Period. Cureus. 2024;16(2):e53465.
- Castaman G, James PD. Pregnancy and delivery in women with von Willebrand disease. Eur J Haematol. 2019;103(2):73-9.
- Rauch A, Caron C, Susen S, Goudemand J. Facteur von Willebrand et maladie de Willebrand : nouvelles approches. Revue Francophone des Laboratoires. 2014;2014(463):53-63.
- Pacheco LD, Saade GR, James AH. Von Willebrand Disease, Hemophilia, and Other Inherited Bleeding Disorders in Pregnancy. 2023;141(3):493-504.
- van der Zwet K, van Galen KPM, Evers ACC, Fischer K, Schutgens REG, van Vulpen LFD. Navigating the challenges: a case report on managing a complicated postpartum course in type 3 von Willebrand disease with alloantibodies. Res Pract Thromb Haemost. 2024;8(3):102399.
- Calmette L, Clauser S. [Von Willebrand disease]. Rev Med Interne. 2018;39(12):918-24.
- Eladly F, Miesbach W. Von Willebrand Disease-Specific Aspects in Women. Hamostaseologie. 2022;42(5):330-6.
- Baouahi H, Zerqouni Y, Doumiri M, Oudghiri N, Saoud AT. [The role of the anesthesiologist in the care of the pregnant woman with Von Willebrand Disease]. Pan Afr Med J. 2015;22:335.
- Roth CK, Syed LJ. von Willebrand disease in pregnancy. Nurs Womens Health. 2016;20(5):501-5.
- Blandinières A, Lavenu-Bombled C. Déficits constitutionnels rares de la coagulation et anesthésie. Le Praticien en Anesthésie Réanimation. 2024;28(2):67-76.
Von Willebrand disease (VWD), the most common inherited bleeding disorder, is classified into types 1, 2, and 3.
Women with VWD are at higher risk of bleeding during menstruation, childbirth, and postpartum.
This case of a 24-year-old pregnant woman with VWD underscores the importance of early management to prevent
postpartum hemorrhage. Desmopressin and VWF infusion enabled a successful cesarean and uneventful recovery.
Diagnosis relies on VWF and FVIII assays, and prophylactic treatment is advised during pregnancy. Vaginal delivery
without instrumentation is preferred, with cesarean reserved for obstetric reasons.
Keywords :
Von Willebrand Disease, Deficiency, Haemorrhage, Pregnancy.