Authors : Dr. Abhishek Reghunadhan; Dr. Pradeepgoud H Patil

Volume/Issue : Volume 10 - 2025, Issue 3 - March

---

Google Scholar : https://tinyurl.com/epdvtcvz

Scribd : https://tinyurl.com/4bfz6tte

DOI : https://doi.org/10.38124/ijisrt/25mar1162

Google Scholar

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Note : Google Scholar may take 15 to 20 days to display the article.

---

Abstract : Ependymomas are rare tumors of the central nervous system (CNS), accounting for about 2-6% of all intracranial neoplasms. High-grade posterior fossa ependymomas, particularly WHO Grade 3 anaplastic ependymomas, present significant clinical and radiological challenges due to their aggressive behavior and recurrence potential. This report describes a case of a 60-year-old female with a posterior fossa mass causing obstructive hydrocephalus, ultimately diagnosed as WHO Grade 3 posterior fossa ependymoma. This case emphasizes key imaging characteristics, differential diagnoses, and the clinical implications of high-grade ependymomas.

References :

1. Ostrom QT, Cioffi G, Gittleman H, et al. CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017. Neuro Oncol. 2020;22(Suppl 1):iv1-iv96.
2. Louis DN, Perry A, Wesseling P, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 2021;23(8):1231-1251.
3. Koeller KK, Rushing EJ. Medulloblastoma: A comprehensive review with radiologic-pathologic correlation. Radiographics. 2003;23(6):1613-1637.
4. Barkovich AJ. Pediatric Neuroimaging. 5th ed. Lippincott Williams & Wilkins; 2012.
5. Smirniotopoulos JG, Murphy FM. The phakomatoses as systemic diseases. Radiographics. 1992;12(6):1195-1215.
6. Zeller RW, Reddy AT, Bhatoe HS. Choroid plexus papillomas: A review. Surg Neurol Int. 2012;3(1):31.
7. Merchant TE, Wozniak AW. Ependymoma: Radiation therapy treatment and trials. J Child Neurol. 2009;24(11):1401-1408.
8. Mangano FT, Poretti A, Meoded A, et al. Imaging features of pediatric brain tumors. Childs Nerv Syst. 2012;28(10):1675-1698.
9. Perreault S, Ramaswamy V, Achrol AS, et al. Posterior fossa ependymomas: a review of molecular classification, treatment strategies, and future directions. Front Oncol. 2019;9:12.
10. Gajjar A, Bowers DC, Karajannis MA, et al. Pediatric brain tumors: Innovative genomic approaches and targeted therapies. Lancet Oncol. 2019;20(6):e293-e305.
11. Massimino M, Antonelli M, Gandola L, et al. Chemotherapy for ependymoma in children. Childs Nerv Syst. 2009;25(10):1267-1273.
12. Vera-Bolanos E, Aldape K, Yuan Y, et al. Clinical course and progression-free survival of adult intracranial ependymoma patients. Neuro Oncol. 2015;17(4):588-596.