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A Retrospective Comparative Study of Clinical Outcomes of PRP vs Corticosteroid Injection in Frozen Shoulder


Authors : Dr. Pardeep Duhan; Dr. Dhruv Lashkare; Dr. Apoorv Jha

Volume/Issue : Volume 11 - 2026, Issue 4 - April


Google Scholar : https://tinyurl.com/y9cdnf49

Scribd : https://tinyurl.com/3987v4vm

DOI : https://doi.org/10.38124/ijisrt/26apr1492

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Background: Adhesive capsulitis (frozen shoulder) is a painful and disabling condition characterized by progressive restriction of active and passive shoulder movements due to capsular inflammation and fibrosis [1-3]. Intra-articular corticosteroid injections are widely used for rapid pain relief, while platelet-rich plasma (PRP) has emerged as a biological treatment aimed at promoting tissue healing and long-term functional recovery [4-8].  Aim: To retrospectively compare the clinical outcomes of platelet-rich plasma injection versus corticosteroid injection in the treatment of adhesive capsulitis.  Methods: This retrospective comparative observational study was conducted at RKDF Medical College Hospital & Research Center. Medical records of 150 patients diagnosed with adhesive capsulitis and treated with either intra-articular PRP injection or corticosteroid injection were reviewed using purposive sampling. Patients aged 30-70 years with complete clinical and follow-up data were included and divided into two groups of 75 each. Outcome measures included pain assessment using the Visual Analogue Scale (VAS), shoulder range of motion, and functional scores (SPADI/ConstantMurley). Follow-up data were analyzed at 2 weeks, 6 weeks, 3 months, and 6 months. Statistical analysis was performed using independent t-test, paired t-test, and chi-square test, with p < 0.05 considered statistically significant.  Results: Both treatment modalities resulted in significant improvement in pain, range of motion, and functional outcomes. Corticosteroid injections provided faster short-term pain relief, particularly during early follow-up, whereas PRP injections demonstrated more sustained improvement in shoulder mobility and functional scores at later follow-ups, especially at 3 and 6 months [7-12].  Conclusion: PRP injection appears to provide superior long-term clinical outcomes compared with corticosteroid injection, although corticosteroids remain effective for rapid short-term symptom relief. PRP may be considered a promising alternative treatment for adhesive capsulitis, particularly in patients requiring sustained functional improvement [10-16].

Keywords : Adhesive Capsulitis, Frozen Shoulder, Platelet-Rich Plasma, Corticosteroid Injection, PRP, SPADI.

References :

  1. Neviaser AS, Hannafin JA. Adhesive capsulitis: a review of current treatment. Am J Sports Med. 2010;38(11):2346-2356. https://doi.org/10.1177/0363546510378041
  2. Sun Y, Zhang P, Liu S, Li H, Jiang J, Chen S, et al. Intra-articular steroid injection for frozen shoulder: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. Am J Sports Med. 2017;45(9):2171-2179. https://doi.org/10.1177/0363546516660078
  3. Uppal HS, Evans JP, Smith C. Frozen shoulder: a systematic review of therapeutic options. World J Orthop. 2015;6(2):263-268. https://doi.org/10.5312/wjo.v6.i2.263
  4. Challoumas D, Biddle M, McLean M, Millar NL. Comparison of treatments for frozen shoulder: a systematic review and meta-analysis. JAMA Netw Open. 2020;3(12):e2029581. https://doi.org/10.1001/jamanetworkopen.2020.29581
  5. Griesser MJ, Harris JD, Campbell JE, Jones GL. Adhesive capsulitis of the shoulder: a systematic review of the effectiveness of intra-articular corticosteroid injections. J Bone Joint Surg Am. 2011;93(18):1727-1733. https://doi.org/10.2106/JBJS.J.00743
  6. Cho CH, Bae KC, Kim DH. Treatment strategy for frozen shoulder. Clin Orthop Surg. 2019;11(3):249-257. https://doi.org/10.4055/cios.2019.11.3.249
  7. Lin J. Platelet-rich plasma injection in the treatment of frozen shoulder: a randomized controlled trial with 6-month follow-up. Int J Clin Pharmacol Ther. 2018;56(8):366-371. https://doi.org/10.5414/CP203143
  8. Thu AC, Kwak SG, Shein WN, Htun LM, Htwe TT, Chang MC. Comparison of ultrasound-guided platelet-rich plasma injection and conventional physical therapy for management of adhesive capsulitis: a randomized trial. J Int Med Res. 2020;48(12):300060520976032. https://doi.org/10.1177/0300060520976032
  9. Barman A, Mukherjee S, Sahoo J, Maiti R, Rao PB, Sinha MK, et al. Single intra-articular platelet-rich plasma versus corticosteroid injections in the treatment of adhesive capsulitis of the shoulder: a cohort study. Am J Phys Med Rehabil. 2019;98(7):549-557. https://doi.org/10.1097/PHM.0000000000001164
  10. Prodromidis AD, Charalambous CP. Is there a role for platelet-rich plasma in adhesive capsulitis? Shoulder Elbow. 2021;13(4):448-456. https://doi.org/10.1177/1758573220945461
  11. Harna B, Gupta V, Arya S, Jeyaraman N, Rajendran RL, Jeyaraman M, et al. Current role of intra-articular injections of platelet-rich plasma in adhesive capsulitis of shoulder: a systematic review. Bioengineering (Basel). 2023;10(1):21. https://doi.org/10.3390/bioengineering10010021
  12. Karabas C, Talay Calis H, Ozmerdivenli R, Evcik E, Ozcakar L. Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: a prospective, randomized-controlled study. Turk J Phys Med Rehabil. 2021;67(4):462-472.https://doi.org/10.5606/tftrd.2021.5465
  13. Yu S, Hu R, Feng H, Huang D. Efficacy of platelet-rich plasma injection in the treatment of frozen shoulder: a systematic review and meta-analysis. J Back Musculoskelet Rehabil. 2023;36(3):551-564. https://doi.org/10.3233/BMR-220327
  14. Blanchard V, Barr S, Cerisola FL. Platelet-rich plasma for adhesive capsulitis: a systematic review. Cureus. 2023;15(10):e46530.https://doi.org/10.7759/cureus.46530
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  16. Lin HW, Tam KW, Liou TH, Rau CL, Huang SW, Hsu TH. Efficacy of platelet-rich plasma injection on range of motion, pain, and disability in patients with adhesive capsulitis: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2023;104(12):2109-2122.  https://doi.org/10.1016/j.apmr.2023.06.012
  17. Pretorius J, Mirdad R, Nemat N, Ghobrial BZ, Murphy C. The efficacy of platelet-rich plasma injections compared to corticosteroids and physiotherapy in adhesive capsulitis: a systematic review and meta-analysis. J Orthop. 2023;47:35-44. https://doi.org/10.1016/j.jor.2023.03.010
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  20. Valencia R, Anche G, Cao V, Chen D, Gonzalez J, Gurin M, et al. Comparative efficacy of platelet-rich plasma, hyaluronic acid, and corticosteroid injections in adhesive capsulitis management: a meta-analysis. PM R. 2025;17(2):216-223. https://doi.org/10.1002/pmrj.13005
  21. Singh S, Agarwal P, Sharma A. One year results of intraarticular platelet rich plasma in adhesive capsulitis of shoulder. J Orthop Rep. 2025;4:100532. https://doi.org/10.1016/j.jorep.2025.100532
  22. Kusuma HC, Hsiao MY, Kuo YH, Chang KV. Comparison of platelet-rich plasma injection versus corticosteroid injection for the treatment of frozen shoulder in Asia: a systematic review and meta-analysis of randomized controlled trials. Tzu Chi Med J. 2026.

Background: Adhesive capsulitis (frozen shoulder) is a painful and disabling condition characterized by progressive restriction of active and passive shoulder movements due to capsular inflammation and fibrosis [1-3]. Intra-articular corticosteroid injections are widely used for rapid pain relief, while platelet-rich plasma (PRP) has emerged as a biological treatment aimed at promoting tissue healing and long-term functional recovery [4-8].  Aim: To retrospectively compare the clinical outcomes of platelet-rich plasma injection versus corticosteroid injection in the treatment of adhesive capsulitis.  Methods: This retrospective comparative observational study was conducted at RKDF Medical College Hospital & Research Center. Medical records of 150 patients diagnosed with adhesive capsulitis and treated with either intra-articular PRP injection or corticosteroid injection were reviewed using purposive sampling. Patients aged 30-70 years with complete clinical and follow-up data were included and divided into two groups of 75 each. Outcome measures included pain assessment using the Visual Analogue Scale (VAS), shoulder range of motion, and functional scores (SPADI/ConstantMurley). Follow-up data were analyzed at 2 weeks, 6 weeks, 3 months, and 6 months. Statistical analysis was performed using independent t-test, paired t-test, and chi-square test, with p < 0.05 considered statistically significant.  Results: Both treatment modalities resulted in significant improvement in pain, range of motion, and functional outcomes. Corticosteroid injections provided faster short-term pain relief, particularly during early follow-up, whereas PRP injections demonstrated more sustained improvement in shoulder mobility and functional scores at later follow-ups, especially at 3 and 6 months [7-12].  Conclusion: PRP injection appears to provide superior long-term clinical outcomes compared with corticosteroid injection, although corticosteroids remain effective for rapid short-term symptom relief. PRP may be considered a promising alternative treatment for adhesive capsulitis, particularly in patients requiring sustained functional improvement [10-16].

Keywords : Adhesive Capsulitis, Frozen Shoulder, Platelet-Rich Plasma, Corticosteroid Injection, PRP, SPADI.

Paper Submission Last Date
31 - May - 2026

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