Authors : Zinney Moriju; Yugam Bansal; Abhishek; Wajid Shafi Beigh; Jagroop Singh; Poonam Bhauta

Volume/Issue : Volume 9 - 2024, Issue 4 - April

Google Scholar : https://tinyurl.com/y3rzh24k

Scribd : https://tinyurl.com/asjpceft

DOI : https://doi.org/10.38124/ijisrt/IJISRT24APR2622

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Cancer, generally characterized by uncontrollable growth of abnormal cells that metastasize to other parts of the body. It is a one of the leading concerned disease that affects the worldwide population. It can originate from almost any organ or tissue and are of various types; leukemia, lung cancer, lymphoma, stomach cancer, cervical cancer. Flavonoids and Isoflavonoids are naturally occurring polyphenolic secondary metabolites that possess numerous medicinal benefits including antioxidant, anti-inflammatory, anticancer and antiviral properties. Potential agents derived from flavonoids and isoflavonoids for its anticancer activity have been studied. Due to recent technological advancement, the detailed study of any moiety and molecules is possible. A virtual screening of flavonoids was carried out using molecular docking, drug similarity, ADMET prediction, drug likeness, chemical and physicochemical properties to determine its potential anticancer activity with the use of Swiss ADME and Chem Draw software. In this review, analysis of drug likeness properties of flavonoids and isoflavonoids was thoroughly performed. Additionally, structures were examined and observed for better interaction of flavonoids scaffold with receptors. Due to their great stability, flavonoids are strongly recommended as anticancer medicines for various cancer stages.

References :

1. Rampogu S, Gajula RG, Lee KW. A comprehensive review on chemotherapeutic potential of galangin. Biomedicine & Pharmacotherapy. 2021;141:111808.
2. Zhong H, Xiao M, Zarkovic K, Zhu M, Sa R, Lu J, et al. Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer. Free Radical Biology and Medicine. 2017;102:67-76.
3. Wu M, Luo Q, Nie R, Yang X, Tang Z, Chen H. Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota. Critical reviews in food science and nutrition. 2021;61(13):2175-93.
4. Abotaleb M, Samuel SM, Varghese E, Varghese S, Kubatka P, Liskova A, Büsselberg D. Flavonoids in cancer and apoptosis. Cancers. 2018;11(1):28.
5. Liskova A, Koklesova L, Samec M, Smejkal K, Samuel SM, Varghese E, et al. Flavonoids in cancer metastasis. Cancers. 2020;12(6):1498.
6. Manzoor A, Dar IH, Bhat SA, Ahmad S. Flavonoids: health benefits and their potential use in food systems. Functional food products and sustainable health. 2020:235-56.
7. Hossain MM, Mahmood S, Tanmy TT. The beneficial effects of green tea on human health: An updated review. Int J Herb Med. 2020;63:63-73.
8. Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J. Flavonoids as anticancer agents. Nutrients. 2020;12(2):457.
9. Dorta DJ, Pigoso AA, Mingatto FE, Rodrigues T, Prado IM, Helena AF, et al. The interaction of flavonoids with mitochondria: effects on energetic processes. Chemico-biological interactions. 2005;152(2-3):67-78.
10. Vegliante R, Di Leo L, Ciccarone F, Ciriolo MR. Hints on ATGL implications in cancer: beyond bioenergetic clues. Cell death & disease. 2018;9(3):316.
11. Lu S, Wang Y. Nonmetabolic functions of metabolic enzymes in cancer development. Cancer Communications. 2018;38:1-7.
12. Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K. Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Progress in lipid research. 2013;52(4):585-9.
13. Weinberg F, Ramnath N, Nagrath D. Reactive oxygen species in the tumor microenvironment: an overview. Cancers. 2019;11(8):1191.
14. Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN. Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. Journal of lipid research. 2008;49(12):2545-56.
15. Bock FJ, Tait SW. Mitochondria as multifaceted regulators of cell death. Nature reviews Molecular cell biology. 2020;21(2):85-100.
16. Patel D, Shukla S, Gupta S. Apigenin and cancer chemoprevention: progress, potential and promise. International journal of oncology. 2007;30(1):233-45.
17. Yan X, Qi M, Li P, Zhan Y, Shao H. Apigenin in cancer therapy: Anti-cancer effects and mechanisms of action. Cell & bioscience. 2017;7:1-16.
18. Noori SD, Kadhi MS, Najm MA, Oudah KH, Qasim QA, Al-Salman H. In-vitro evaluation of anticancer activity of natural flavonoids, apigenin and hesperidin. Materials Today: Proceedings. 2022;60:1840-3.
19. Tuli HS, Tuorkey MJ, Thakral F, Sak K, Kumar M, Sharma AK, et al. Molecular mechanisms of action of genistein in cancer: Recent advances. Frontiers in Pharmacology. 2019;10:489844.
20. Li Q-S, Li C-Y, Li Z-L, Zhu H-L. Genistein and its synthetic analogs as anticancer agents. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2012;12(3):271-81.
21. Jeune ML, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. Journal of medicinal food. 2005;8(4):469-75.
22. Lee J-Y, Kim HS, Song Y-S. Genistein as a potential anticancer agent against ovarian cancer. Journal of Traditional and Complementary Medicine. 2012;2(2):96-104.
23. Chae H-S, Xu R, Won J-Y, Chin Y-W, Yim H. Molecular targets of genistein and its related flavonoids to exert anticancer effects. International Journal of Molecular Sciences. 2019;20(10):2420.
24. Zhang J, Song J, Wu D, Wang J, Dong W. Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium. Medical Oncology. 2015;32:1-11.
25. Sohel M, Sultana H, Sultana T, Al Amin M, Aktar S, Ali MC, et al. Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review. Heliyon. 2022;8(1).
26. Zhang J, Wu D, Vikash, Song J, Wang J, Yi J, Dong W. Hesperetin induces the apoptosis of gastric cancer cells via activating mitochondrial pathway by increasing reactive oxygen species. Digestive diseases and sciences. 2015;60:2985-95.
27. Tang S-M, Deng X-T, Zhou J, Li Q-P, Ge X-X, Miao L. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomedicine & Pharmacotherapy. 2020;121:109604.
28. Vijayalakshmi A, Kumar P, Sakthi Priyadarsini S, Meenaxshi C. In vitro antioxidant and anticancer activity of flavonoid fraction from the aerial parts of Cissus quadrangularis Linn. against human breast carcinoma cell lines. Journal of Chemistry. 2013;2013.
29. Davoodvandi A, Shabani Varkani M, Clark CC, Jafarnejad S. Quercetin as an anticancer agent: Focus on esophageal cancer. Journal of Food Biochemistry. 2020;44(9):e13374.
30. Massi A, Bortolini O, Ragno D, Bernardi T, Sacchetti G, Tacchini M, De Risi C. Research progress in the modification of quercetin leading to anticancer agents. Molecules. 2017;22(8):1270.
31. Ranganathan S, Halagowder D, Sivasithambaram ND. Quercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cells. PloS one. 2015;10(10):e0141370.
32. Li ShiZheng LS, Yuan Song YS, Zhao Qian ZQ, Wang Bo WB, Wang XiuYan WX, Li Kun LK. Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. 2018.
33. Thuy NTT, Lee J-E, Yoo HM, Cho N. Antiproliferative pterocarpans and coumestans from Lespedeza bicolor. Journal of natural products. 2019;82(11):3025-32.
34. Peng T-T, Sun X-R, Liu R-H, Hua L-X, Cheng D-P, Mao B, Li X-N. Cytisine-Pterocarpan Derived Compounds: Biomimetic Synthesis and Apoptosis-Inducing Activity in Human Breast Cancer Cells. Molecules. 2018;23(12):3059.
35. Mahajan P, Gnana Oli R, Jachak SM, Bharate SB, Chaudhuri B. Antioxidant and antiproliferative activity of indigocarpan, a pterocarpan from Indigofera aspalathoides. Journal of Pharmacy and Pharmacology. 2016;68(10):1331-9.
36. Militão GC, Dantas IN, Pessoa C, Falcão MJC, Silveira ER, Lima MAS, et al. Induction of apoptosis by pterocarpans from Platymiscium floribundum in HL-60 human leukemia cells. Life sciences. 2006;78(20):2409-17.
37. Kuete V, Sandjo LP, Djeussi DE, Zeino M, Kwamou GM, Ngadjui B, Efferth T. Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells. Investigational New Drugs. 2014;32:1053-62.