A Review on Co-Crystallization: A Novel Technique for Enhancement of Solubility and Bioavailability

Authors : Amruta A. Nangare; Atul R. Chopade; Hemant S Kandle

Volume/Issue : Volume 8 - 2023, Issue 7 - July

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/33kkawe7

DOI : https://doi.org/10.5281/zenodo.8204665

Drugs' poor oral bioavailability and poor solubility are the main issues throughout the design and development of new products. Although they have significant drawbacks, traditional approaches have been used to increase the solubility of medications that are weakly soluble in water, such as solvates, salts, and polymorphs. The co-crystallization strategy is utilised as an alternate method to modify the physicochemical properties of an active pharmaceutical ingredient without changing its pharmacological action, such as solubility, bioavailability, permeability, flowability, and melting point. Drug and co-former are both included in co- crystals, which are multi-component crystalline systems with the same crystal lattice. A comprehensive overview of pharmaceutical co-crystals is provided in this review article. This page provides a summary of the benefits, co- crystal formation processes, evaluation, and characterisation testing.

Keywords : co-crystals, solubility, bioavailability, physiochemical, crystal lattice.


Paper Submission Last Date
31 - December - 2023

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