Drugs' poor oral bioavailability and poor
solubility are the main issues throughout the design and
development of new products. Although they have
significant drawbacks, traditional approaches have been
used to increase the solubility of medications that are
weakly soluble in water, such as solvates, salts, and
polymorphs. The co-crystallization strategy is utilised as
an alternate method to modify the physicochemical
properties of an active pharmaceutical ingredient without
changing its pharmacological action, such as solubility,
bioavailability, permeability, flowability, and melting
point. Drug and co-former are both included in co-
crystals, which are multi-component crystalline systems
with the same crystal lattice. A comprehensive overview
of pharmaceutical co-crystals is provided in this review
article. This page provides a summary of the benefits, co-
crystal formation processes, evaluation, and
characterisation testing.
Keywords : co-crystals, solubility, bioavailability, physiochemical, crystal lattice.