Authors : Himani Mevada; Dr. Dhiren L. Chaudhary; Ami H. Patel; Dr. Indermeet Singh Anand

Volume/Issue : Volume 11 - 2026, Issue 1 - January

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Google Scholar : https://tinyurl.com/3jjnnexj

Scribd : https://tinyurl.com/mr4342t4

DOI : https://doi.org/10.38124/ijisrt/26jan1600

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Abstract : Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disorder caused by the abnormal reflux of gastric contents into the esophagus, resulting in symptoms and potential mucosal injury. Its pathogenesis involves lower esophageal sphincter dysfunction, impaired esophageal clearance, delayed gastric emptying, and exposure to acidic and nonacidic refluxate. GERD presents as erosive or non-erosive disease, with varying risks of complications such as Barrett’s esophagus. Management includes lifestyle modifications and pharmacological therapy, with proton pump inhibitors as firstline agents. Emerging therapies, including potassium-competitive acid blockers, offer alternative approaches. This review highlights the epidemiology, pathophysiology, clinical features, and current treatment strategies for GERD.

Keywords : Gastroesophageal Reflux Disease; Risk Factors; Proton Pump Inhibitors; Potassium-Competitive Acid Blockers.

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