Authors :
Pankaj Chhikara; S.K Dhattarwal; Monika Jindal
Volume/Issue :
Volume 7 - 2022, Issue 10 - October
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3SgRNWp
DOI :
https://doi.org/10.5281/zenodo.7226998
Abstract :
Aluminum phosphide (AlP) is a cheap solid
fumigant and a highly toxic pesticide which is commonly
used for grain preservation. Aluminum phosphide has
currently aroused interest with increasing number of
cases in the past four decades due to increased use in
agricultural and non-agricultural purposes and its easy
availability in the markets has increased its misuse to
commit suicide. Upon contact with moisture in the
environment, Aluminum phosphide undergoes a chemical
reaction yielding phosphine gas, which is the active
pesticidal component. Phosphine inhibits cellular oxygen
utilization and can induce lipid peroxidation. It was
reported that Aluminum phosphide has a mortality rate
more than 50% of intoxication cases. Poisoning with
Aluminum phosphide has usually occurred in attempts to
suicide. It is a more common case in adults rather than
teenagers. In some eastern countries it is a quite common
agent with rapid action for suicide. Up to date, there is no
effective antidote or treatment for its intoxication the
oxidative outcomes of phosphine. This article reviews the
experimental and clinical features of Aluminum
phosphide intoxication and tries to suggest a way to
encounter its poisoning.
Keywords :
Aluminum Phosphide, Phosphine, Management, Poisoning, Suicide.
Aluminum phosphide (AlP) is a cheap solid
fumigant and a highly toxic pesticide which is commonly
used for grain preservation. Aluminum phosphide has
currently aroused interest with increasing number of
cases in the past four decades due to increased use in
agricultural and non-agricultural purposes and its easy
availability in the markets has increased its misuse to
commit suicide. Upon contact with moisture in the
environment, Aluminum phosphide undergoes a chemical
reaction yielding phosphine gas, which is the active
pesticidal component. Phosphine inhibits cellular oxygen
utilization and can induce lipid peroxidation. It was
reported that Aluminum phosphide has a mortality rate
more than 50% of intoxication cases. Poisoning with
Aluminum phosphide has usually occurred in attempts to
suicide. It is a more common case in adults rather than
teenagers. In some eastern countries it is a quite common
agent with rapid action for suicide. Up to date, there is no
effective antidote or treatment for its intoxication the
oxidative outcomes of phosphine. This article reviews the
experimental and clinical features of Aluminum
phosphide intoxication and tries to suggest a way to
encounter its poisoning.
Keywords :
Aluminum Phosphide, Phosphine, Management, Poisoning, Suicide.
