Authors :
Afolabi Nasimot Omowunmi; Ayinde Yusuf Olarewaju
Volume/Issue :
Volume 11 - 2026, Issue 6 - June
Google Scholar :
https://tinyurl.com/rx7d2rvw
Scribd :
https://tinyurl.com/4xwc7xa9
DOI :
https://doi.org/10.38124/ijisrt/26jun1432
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
This study “A Statistical Analysis Of Risk Factors Associated With Coronary Heart Disease” statistically
examined demographic, lifestyle, and clinical determinants of ten-year CHD risk using secondary data from 200 individuals
obtained from the Kaggle cardiovascular dataset. A quantitative, cross-sectional design was adopted, and analysis was
conducted using descriptive statistics, correlation analysis, and multivariate logistic regression. Results showed that the
sample consisted mostly of middle-aged adults, with notable prevalence of hypertension, obesity, elevated cholesterol, and
smoking. Correlation analysis revealed that age, total cholesterol, blood pressure, BMI, and hypertension were positively
associated with CHD risk. Logistic regression analysis demonstrated that total cholesterol was the only statistically
significant independent predictor of tenyear CHD risk (p = 0.01), while other factors including smoking status, blood
pressure, diabetes, and BMI did not attain statistical significance after adjustment. The model exhibited good fit (Pearson
Chi-square p = 0.3868) and strong predictive accuracy (AUC = 0.763). The study concludes that elevated cholesterol remains
the most critical predictor of long-term CHD risk in this population. It recommends prioritizing lipid screening, early risk
assessment among middle-aged adults, and strengthened public health interventions targeting modifiable cardiovascular
risk factors. Further research with larger and more diverse samples is advised to improve generalizability and refine CHD
predictive models.
Keywords :
Coronary Heart Disease, Risk Factors, Logistic Regression, Cholesterol, Cardiovascular Epidemiology.
References :
- American Heart Association. (2023). Heart disease and stroke statistics—2023 update. American Heart Association.
- Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., … Virani, S. S. (2019). 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology, 74(10), e177– e232. https://doi.org/10.1016/j.jacc.2019.03.010
- Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., … American Heart Association Council. (2019). Heart disease and stroke statistics—2019 update: A report from the American Heart Association. Circulation, 139(10), e56–e528. https://doi.org/10.1161/CIR.0000000000000659
- Björkegren, J. L. M., & Lusis, A. J. (2022). Atherosclerosis: Recent developments. Cell, 185(10), 1630–1645. https://doi.org/10.1016/j.cell.2022.04.013
- Cholesterol Treatment Trialists’ (CTT) Collaboration. (2010). Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials. The Lancet, 376(9753), 1670–1681. https://doi.org/10.1016/S0140-6736(10)61350-5
- D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008). General cardiovascular risk profile for use in primary care: The Framingham Heart Study. Circulation, 117(6), 743–753. https://doi.org/10.1161/CIRCULATIONAHA.107.699579
- Emerging Risk Factors Collaboration. (2010). Diabetes mellitus, fasting glucose, and risk of causespecific death. New England Journal of Medicine, 364(9), 829–841. https://doi.org/10.1056/NEJMoa1008862
- GBD 2020 Risk Factors Collaborators. (2020). Global burden of 87 risk factors in 204 countries and territories, 1990–2019: A systematic analysis. The Lancet, 396(10258), 1223–1249. https://doi.org/10.1016/S0140-6736(20)30752-2
- Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., … Yeboah, J. (2019). 2018 ACC/AHA guideline on the management of blood cholesterol. Journal of the American College of Cardiology, 73(24), e285–e350. https://doi.org/10.1016/j.jacc.2018.11.003
- Lewington, S., Clarke, R., Qizilbash, N., Peto, R., & Collins, R. (2002). Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. The Lancet, 360(9349), 1903–1913. https://doi.org/10.1016/S0140-6736(02)11911-8.
- Libby, P. (2021). The changing landscape of atherosclerosis. Nature, 592(7855), 524–533. https://doi.org/10.1038/s41586-021-03392-8.
- Libby, P., Buring, J. E., Badimon, L., Hansson, G. K., Deanfield, J., & Bittencourt, M. S. (2019). Atherosclerosis. Nature Reviews Disease Primers, 5(56), 1–18. https://doi.org/10.1038/s41572019-0106-z.
- Morrison, A. (2023). Advances in cardiovascular prevention: Integrating risk factors and lifestyle interventions. Journal of Preventive Cardiology, 12(2), 115–128.
- Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., … Williams, B. (2021). 2021 ESC guidelines on cardiovascular disease prevention in clinical practice. European Heart Journal, 42(34), 3227–3337. https://doi.org/10.1093/eurheartj/ehab484.
- World Health Organization. (2021). Cardiovascular diseases (CVDs). https://www.who.int/newsroom/fact-sheets/detail/cardiovascular-diseases.
This study “A Statistical Analysis Of Risk Factors Associated With Coronary Heart Disease” statistically
examined demographic, lifestyle, and clinical determinants of ten-year CHD risk using secondary data from 200 individuals
obtained from the Kaggle cardiovascular dataset. A quantitative, cross-sectional design was adopted, and analysis was
conducted using descriptive statistics, correlation analysis, and multivariate logistic regression. Results showed that the
sample consisted mostly of middle-aged adults, with notable prevalence of hypertension, obesity, elevated cholesterol, and
smoking. Correlation analysis revealed that age, total cholesterol, blood pressure, BMI, and hypertension were positively
associated with CHD risk. Logistic regression analysis demonstrated that total cholesterol was the only statistically
significant independent predictor of tenyear CHD risk (p = 0.01), while other factors including smoking status, blood
pressure, diabetes, and BMI did not attain statistical significance after adjustment. The model exhibited good fit (Pearson
Chi-square p = 0.3868) and strong predictive accuracy (AUC = 0.763). The study concludes that elevated cholesterol remains
the most critical predictor of long-term CHD risk in this population. It recommends prioritizing lipid screening, early risk
assessment among middle-aged adults, and strengthened public health interventions targeting modifiable cardiovascular
risk factors. Further research with larger and more diverse samples is advised to improve generalizability and refine CHD
predictive models.
Keywords :
Coronary Heart Disease, Risk Factors, Logistic Regression, Cholesterol, Cardiovascular Epidemiology.