Authors :
Dhanushya N.; Sowmiya S.; Dr. V. Raveenthiran; Dr. G. Veeramani
Volume/Issue :
Volume 11 - 2026, Issue 5 - May
Google Scholar :
https://tinyurl.com/3h6uvffj
Scribd :
https://tinyurl.com/bdmf69uy
DOI :
https://doi.org/10.38124/ijisrt/26May2163
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background:
Antibiotics play a crucial role in preventing and treating infections among pediatric surgical patients. Appropriate
prophylactic and postoperative antibiotic use can reduce surgical site infections (SSI), antimicrobial resistance, and
healthcare costs. This study evaluated antibiotic utilization patterns, therapeutic outcomes, and patient medication
adherence in children undergoing surgical procedures in a rural teaching hospital.
Methods:
A prospective observational study was conducted over six months among 90 pediatric patients admitted in the
Department of Pediatric Surgery. Data regarding demographics, surgical diagnosis, antibiotic prophylaxis, postoperative
antibiotic use, SSI occurrence, and medication adherence were collected using a structured proforma and analyzed
statistically.
Results:
Among 90 patients, 62.2% received prophylactic antibiotics, predominantly via the intravenous route. Cefotaxime,
Gentamicin, and Metronidazole were the most commonly prescribed antibiotics. Surgical site infection developed in only
5.6% of patients, and no adverse drug reactions were reported. Most patients received short-term antibiotic therapy and
had hospital stays of 1–5 days. Medication adherence improved after counselling, with 97.8% of patients demonstrating
good to very good compliance.
Conclusion:
Intravenous antibiotics were the primary mode of prophylactic and postoperative management, with Cefotaxime and
Gentamicin being the most frequently utilized agents. The low SSI rate, absence of adverse drug reactions, and improved
medication adherence indicate effective antibiotic utilization and favorable clinical outcomes among pediatric surgical
patients.
Keywords :
Surgical Site Infection, Antibiotics, Prophylaxis, Patient Compliance, Medication Adherence.
References :
- Losty, P. D. (1999). Recent advances: Paediatric surgery. BMJ, 318(7199), 1668–1671. https://doi.org/10.1136/bmj.318.7199.1668
- Ozgedez, D., Langer, M., Kisa, P., & Poenaru, D. (2016). Pediatric surgery as an essential component of global child health. Seminars in Pediatric Surgery, 25(1), 3–9. https://doi.org/10.1053/j.sempedsurg.2015.09.002
- National Confidential Enquiry into Patient Outcome and Death. (2004). The NCEPOD classification of intervention. https://www.ncepod.org.uk/classification.html
- Gadiparthi, R., & Waseem, M. (2023, July 9). Pediatric appendicitis. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK558970/
- Puri, P., & Höllwarth, M. E. (Eds.). (2006). Pediatric surgery. Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/3-540-30793-7
- Kurz, D. (2016). Current management of undescended testes. Current Treatment Options in Pediatrics, 2(1), 43–51. https://doi.org/10.1007/s40746-016-0039-7
- Leslie, S. W., Sajjad, H., & Villanueva, C. A. (2024, May 5). Cryptorchidism. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK557510/
- Shahid, S. K. (2012). Phimosis in Children. ISRN Urology, 2012, Article ID 707329, 6 pages. https://doi.org/10.5402/2012/707329
- McPhee, A. S., Stormont, G., & McKay, A. C. (2023). Phimosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557844/ Last updated: August 8, 2023.
- Vigneswaran, R., Cresencyia, J. R., Jeevithalakshmi, P., Sakthisuvetha, R. V., & Senthilkumar, S. R. (2023). Evaluation of prescription pattern of antibiotic for surgical prophylaxis use in a tertiary care hospital. Indian Journal of Pharmacy Practice, 16(1), 20–24. https://doi.org/10.5530/ijopp.16.1.5
- Azoury, S. C., Farrow, N. E., Hu, Q. L., Soares, K. C., Hicks, C. W., Azar, F., Rodríguez-Unda, N., Poruk, K. E., Cornwell, P. C., Bure, K. M., Cooney, C. M., Nguyen, H. T., & Eckhauser, F. E. (2015). Postoperative abdominal wound infection – Epidemiology, risk factors, identification, and management. Chronic Wound Care Management and Research, 2, 137–148. https://doi.org/10.2147/CWCMR.S69105
- Belo, L., Serrano, I., Cunha, E., Oliveira, M., & Carreira, L. M. (2020). Surgical blades as bacteria dissemination vehicles in dogs undergoing surgery – A pilot study. Biomedical Engineering International, 2(1), 25–29. https://doi.org/10.33263/BioMed21.025029
- Onyekwelu, I., Yakkanti, R., Protzer, L., Pinkston, C. M., Tucker, C., & Seligson, D. (2017). Surgical wound classification and surgical site infections in the orthopaedic patient. JAAOS Global Research & Reviews, 1(e022). https://doi.org/10.5435/JAAOSGlobal-D-17-00022
- Downes, K. J., Hahn, A., Wiles, J., Courter, J. D., & Vinks, A. A. (2014). Dose optimisation of antibiotics in children: Application of pharmacokinetics/pharmacodynamics in paediatrics. International Journal of Antimicrobial Agents, 43(3), 223–230. https://doi.org/10.1016/j.ijantimicag.2013.11.006
- Milind, C., & Purandare, S. (2012). A single dose antibiotic prophylaxis in clean surgery: Our experience. Indian Journal of Applied Research, 2(2), 122–123. ISSN: 2249-555X
- Peter M. Nthumba, Yongxu Huang ,Galen Perdikis, Katharina Kranzer. (2022 Aug) Surgical Antibiotic Prophylaxis in Children Undergoing Surgery: A Systematic Review and Meta-Analysis https://doi.org/10.1089/sur.2022.131
- Sunil Pathak1, R. V. Mhapsekar2*, Neeraj Gupta3, Karthik Surabhi1*, Shruchi Bhargava1, Anushka Aggarwal1 (2021 sep) Clinical profile and outcome of pediatric surgical patients in a rural tertiary centre doi.org/10.18203/2349-3291.ijcp20214057 https://1drv.ms/b/c/66dc87c4dcc8de74/EdIiY_XX7PFAmXe97Wfz0kUBZu_vblMBh56pkPjG0BgGJw?e= 0FoPqR
- Thomas J. Sandora, MD, MPH; Monica Fung, MD; Patrice Melvin, MPH; Dionne A. Graham, PhD; Shawn J. Rangel, MD, MSCE (2016) National Variability and Appropriatenessof Surgical Antibiotic Prophylaxis in US Children’s Hospitals DOI 10.1001/jamapediatrics.2016.0019 https://jamanetwork.com/journals/jamapediatrics/fullarticle/2513202
- E. O. Duque-Estrada Æ M. R. Duarte Æ D. M. RodriguesM. D. Raphael (2003) Wound infections in pediatric surgery: a study of 575 patientsin a university hospital. Pediatr Surg Int (2003) 19: 436–438 https://pubmed.ncbi.nlm.nih.gov/12883851/
- Vitchayaporn Emarach Saengow, Phanusorn Chancharoenchai, Weeraphat Saartying, Watcharapong Pimpa, Napat Chotichanon,Thanat Lewsirirat, Phuwadech Srisantisuk (2018) Epilepsy video animation: Impact on knowledge and drug adherence in pediatric epilepsy patients and caregivers Volume 172 Pages 1-190 https://www.sciencedirect.com/journal/clinical-neurology-and-neurosurgery/vol/172/suppl/C
- Mubai Ma a, Qilin Peng a, Xurui Gu a, Yani Hu a, Shusen Sun b, Yanghao Sheng a, Ping Wang a, Hongyi Ma a, Boting Zhou (2019) Pharmacist impact on adherence of valproic acid therapy in pediatric patients with epilepsy using active education techniques. Volume 98, 1-290 https://www.sciencedirect.com/science/article/abs/pii/S152550501930188X
- Doumi et, al. (2010 June) Perspectives on Paediatric Surgical Admissions at El Obeid Hospital, Western Sudan. DOI 10.4314/sjms.v5i1.56030 5 (1) https://www.researchgate.net/publication/272340579_Perspectives_on_Paediatric_Surgical_Admissions_at _El_Obeid_Hospital_Western_Sudan
- Bernhart et al., (2023) Analgesic use and favourable patient-reported outcome measures after paediatric surgery: an analysis of registry data , 130 (1): 74-82 https://www.sciencedirect.com/science/article/pii/S0007091222005694
Background:
Antibiotics play a crucial role in preventing and treating infections among pediatric surgical patients. Appropriate
prophylactic and postoperative antibiotic use can reduce surgical site infections (SSI), antimicrobial resistance, and
healthcare costs. This study evaluated antibiotic utilization patterns, therapeutic outcomes, and patient medication
adherence in children undergoing surgical procedures in a rural teaching hospital.
Methods:
A prospective observational study was conducted over six months among 90 pediatric patients admitted in the
Department of Pediatric Surgery. Data regarding demographics, surgical diagnosis, antibiotic prophylaxis, postoperative
antibiotic use, SSI occurrence, and medication adherence were collected using a structured proforma and analyzed
statistically.
Results:
Among 90 patients, 62.2% received prophylactic antibiotics, predominantly via the intravenous route. Cefotaxime,
Gentamicin, and Metronidazole were the most commonly prescribed antibiotics. Surgical site infection developed in only
5.6% of patients, and no adverse drug reactions were reported. Most patients received short-term antibiotic therapy and
had hospital stays of 1–5 days. Medication adherence improved after counselling, with 97.8% of patients demonstrating
good to very good compliance.
Conclusion:
Intravenous antibiotics were the primary mode of prophylactic and postoperative management, with Cefotaxime and
Gentamicin being the most frequently utilized agents. The low SSI rate, absence of adverse drug reactions, and improved
medication adherence indicate effective antibiotic utilization and favorable clinical outcomes among pediatric surgical
patients.
Keywords :
Surgical Site Infection, Antibiotics, Prophylaxis, Patient Compliance, Medication Adherence.