Authors :
Fathima Shahithaa; Ang Pei Xinb; Mohammed Al-Sibania; Ab. Rahim; Mohd Hasbib; Ahmed Al Harrasic; Asiya Obaid Abdallah Al Saadia
Volume/Issue :
Volume 7 - 2022, Issue 2 - February
Google Scholar :
http://bitly.ws/gu88
Scribd :
https://bit.ly/3Cn6jFM
DOI :
https://doi.org/10.5281/zenodo.6337870
Abstract :
- In this research, highly porous hydroxyethyl
cellulose (HEC) sponges with different concentrations
were prepared and cross linked by which the HEC sponges
were changed from soluble into insoluble from in water
which also enhanced its biodegradability. After the crosslinking process, hydroxyapatite (HA) crystals were formed
on the HEC sponges through the crystallization process by
using 20X simulated body fluid solution (SBF) solution,
and the product was characterized by using FTIR, optical
microscopy, FESEM with EDX, and XRD. From the FTIR
results obtained, the presence of acetal group at the
wavenumbers around 1022.20-1025.83 cm-1 had showed
the cross-linking process was succeeded. FTIR results after
the crystallization showed peak of PO43- and CO32- which
indicate the presence of HA crystals. This result was
confirmed by using XRD and FESEM-EDX. There were
extra peaks shown in the sample after crystallization
compared to the sample before crystallization for the XRD
analysis. This can proved the existence of the HA crystals.
Further confirmation was done by using FESEM-EDX,
and the element composition of HA crystals was revealed,
which consisted of C, O, P and Ca. The morphology and
the size of the HA crystals was determined by using
FESEM. From the results obtained, it showed that HA
crystals synthesized were in round shape, and the size of
the HA crystals increased when the concentration of the
HEC sponges increased. This is due to the polar hydroxyl
side groups of the HEC molecules tend to interact with
Ca2+ during the HA crystallization process. The
hydroxyapatite coated HEC sponges were highly stable in
water and can be a promising scaffold material.
Keywords :
Hydroxyethyl cellulose, biomaterial, hydroxyapatite, freeze drying, simulated body fluid
- In this research, highly porous hydroxyethyl
cellulose (HEC) sponges with different concentrations
were prepared and cross linked by which the HEC sponges
were changed from soluble into insoluble from in water
which also enhanced its biodegradability. After the crosslinking process, hydroxyapatite (HA) crystals were formed
on the HEC sponges through the crystallization process by
using 20X simulated body fluid solution (SBF) solution,
and the product was characterized by using FTIR, optical
microscopy, FESEM with EDX, and XRD. From the FTIR
results obtained, the presence of acetal group at the
wavenumbers around 1022.20-1025.83 cm-1 had showed
the cross-linking process was succeeded. FTIR results after
the crystallization showed peak of PO43- and CO32- which
indicate the presence of HA crystals. This result was
confirmed by using XRD and FESEM-EDX. There were
extra peaks shown in the sample after crystallization
compared to the sample before crystallization for the XRD
analysis. This can proved the existence of the HA crystals.
Further confirmation was done by using FESEM-EDX,
and the element composition of HA crystals was revealed,
which consisted of C, O, P and Ca. The morphology and
the size of the HA crystals was determined by using
FESEM. From the results obtained, it showed that HA
crystals synthesized were in round shape, and the size of
the HA crystals increased when the concentration of the
HEC sponges increased. This is due to the polar hydroxyl
side groups of the HEC molecules tend to interact with
Ca2+ during the HA crystallization process. The
hydroxyapatite coated HEC sponges were highly stable in
water and can be a promising scaffold material.
Keywords :
Hydroxyethyl cellulose, biomaterial, hydroxyapatite, freeze drying, simulated body fluid
