Background Because this job is a part of public service field/sector. Bus-drivers are physically and psychologically get stressed.factors in the working environment that cause stressful situations and negative health consequences of the workplace stress. In short, health outcomes of professional drivers working under highly demanding conditions can be summarized in terms of both physical and mental illnesses, such as: ergonomic complications associated with physical working conditions. respiratory and gastrointestinal disorders, eye problems, lung cancer related to the prolonged exposition to contaminant and toxic gasses, sleep problems and chronic fatigue. Psychological distress and several mental health disturbances such as anxiety, and depressive disorders, have health related adverse working conditions, workplace stress and burnout of various occupational groups to both adverse psychological health indicators (such as the psychological distress measured by the short form of Goldberg’s GHQ- 12) and negative lifestyle outcomes. Aim The aim of this study was to determine whether or not there is a relationship between health-related quality of life and work related stress and to explore if socio- demographic characteristics have an influence on this relationship. Methodology: Research approach : Quantitative research approach Research Variables: In this study research variables are quality of life, job stress, physical health status and perceived illness. Sampling technique: The sampling technique used for the study was purposive sampling technique.Data was collected by using demographic profile, self structured questionnaire on quality of life , job stress and physical health status Results : The data gathered were summarized in the master sheet and both descriptive and inferential statistics were used for analysis. In overall findings reveals that Level of stress mean Value is 142.65 mean value is 118 range of score is 175-85 so that Sd Value is 5.93 R value is -0.201 got p-value is 0.005549 and Quality of life of drivers mean value is 115.18 and median value is 164 and range pf value is 174-106 so got the Sd value 12.48. p-value is 0.005549 So the Hapothesis co-relation is accepted between the stress and quality of life among frofessional drivers Findings revealing the presence of significant difference between stress and quality of life among frofessional drivers.