Problems that might need critical care treatment include complications from surgery, accidents, infections and severe breathing problems. These can sustain life but can also increase the risk of infection. Central venous catheters are the devices that can be inserted under the skin into the larger veins. The study were conducted evaluate the effectiveness before and after implementation of competency programme in improving knowledge and practice regarding central venous catheter care among ICU nurses, Methods: An evaluative research approach was used in the study to determine the effectiveness of competency programmeme in terms of knowledge regarding central venous catheter care among staff nurses working in ICU at selected hospitals, Meerut. The research design selected for the study was Quasi-experimental nonequivalent control group pre-test post-test design. 60 staff nurses (30 in experimental and 30 in control group) were selected in hospital setting by non-probability purposive sampling technique. Structured knowledge questionnaire and checklist were used to assess the knowledge regarding central venous catheter care among staff nurses working in ICU. Results: Conclusion: To conclude it can be said that staff nurses working in ICU were having deficit knowledge regarding CVC care and competency programmeme was found to be an effective method to improve the knowledge of ICU nurses.