A Systematic Review in Pathogenesis, Epidemiology, and Therapeutic Advances of the Trypanosoma Diseases


Authors : Carl Anthony A. Orcales; Jweety Ensalada; Angelyn A. Apitan; ustlene Mae B. Pereira; Cassandra T. Lewis; Gecelene C. Estorico

Volume/Issue : Volume 9 - 2024, Issue 12 - December

Google Scholar : https://tinyurl.com/y9786z5x

Scribd : https://tinyurl.com/mr2tdnf3

DOI : https://doi.org/10.5281/zenodo.14547409

Abstract : This systematic review offers a comparative analysis of Trypanosoma-related diseases, focusing on African Trypanosomiasis (commonly known as sleeping sickness) caused by Trypanosoma brucei and Chagas disease caused by Trypanosoma cruzi. These illnesses represent major public health concerns in sub-Saharan Africa and Latin America, impacting millions of individuals. Although significant progress has been made in understanding the life cycles and host interactions of Trypanosoma species, their mechanisms of pathogenesis remain largely unclear. Additionally, current treatment options are limited and often associated with serious side effects. The review examines the epidemiology, clinical symptoms, and recent developments in therapeutic strategies for these diseases. Its findings aim to guide future research and clinical efforts, addressing knowledge gaps and enhancing treatment outcomes for affected communities.

Keywords : Sleeping Sickness, Host-Parasite Interaction, Vector-borne Diseases, Immune Evasion Mechanisms, Host Invasion, Global Health Burden.

References :

  1. Anis Rassi, Sérgio Gabriel Rassi, (2007). Predictors of Mortality in Chronic Chagas Disease A Systematic Review of Observational Studies. Circulation
  2. Bern, C., Kjos, S., Yabsley, M.J. and Montgomery, S.P., (2011). Trypanosoma cruzi and Chagas’ disease in the United States. Clinical Microbiology Reviews.
  3. B.M. Greenwood, H.C. Whittle (1980). The pathogenesis of sleeping sickness. Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 74, Issue 6, Pages 716-725
  4. Bonnet, Julien, Clotilde Boudot, and Bertrand Courtioux (2015). "Overview of the diagnostic methods used in the field for human African trypanosomiasis: what could change in the next few years?." BioMed research international.
  5. Bouteille, Bernard, and Alain Buguet (2012). "The detection and treatment of human African trypanosomiasis." Research and reports in tropical medicine.
  6. B. Szöőr, E. Silvester, K.R. Matthews, (2020). Leap into the unknown - early events in African trypanosoma transmission. Trends Parasitol.
  7. Büscher, P., Cecchi, G., Jamonneau, V., Priotto, G., (2017). Human African trypanosomiasis. The Lancet.
  8. Cecchi G., Paone M., Feldmann U., Vreysen M. J., Diall O., Mattioli R. C., (2014). Assembling a geospatial database of tsetse-transmitted animal trypanosomosis for Africa. Parasites and Vectors.
  9. Checchi F, Cox AP, Chappuis F, Priotto G, Chandramohan D, Haydon DT., (2012). Prevalence and under-detection of gambiense human African trypanosomiasis during mass screening sessions in Uganda and Sudan. Parasit Vectors.
  10. Center for Disease Control and Prevention (2012). Chagas Disease: What U.S. Clinicians Need to Know.
  11. Chelsea Marie, William A. Petri, Jr., (2022). African Trypanosomiasis (African Sleeping Sickness; Human African Trypanosomiasis; HAT).
  12. Costales JA, Jara-Palacios MA, Llewellyn M, Messenger LA, Ocaña-Mayorga S, Villacís AG. (2015). Trypanosoma cruzi population dynamics in the Central Ecuadorian Coast.
  13. Cucunuba, Z. M., et al. (2024). The epidemiology of Chagas disease in the Americas. The Lancet Regional Health - Americas.
  14. Darvin Scott Smith, MD, MSc, (2023). African Trypanosomiasis (Sleeping sickness). Medscape.
  15. Dickie, E. A., Giordani, F., Gould, M. K., Mäser, P., Burri, C., Mottram, J. C., Rao, S. P. S., & Barrett, M. P. (2020). New drugs for human African trypanosomiasis: a twenty first century success story. Tropical Medicine and Infectious Disease, 5(1), 29.
  16. D. Malvy, F. Chappuis (2011). Sleeping sickness. Clinical Microbiology and Infection, Volume 17, Issue 7, Pages 986-995, ISSN 1198-743X
  17. E.S. Krafsur (2009). Tsetse flies: Genetics, evolution, and role as vectors. Infection, Genetics and Evolution. Volume 9, Issue 1, Pages 124-141,
  18. Franco, J. R., Simarro, P. P., Diarra, A., & Jannin, J. G. (2014). Epidemiology of human African trypanosomiasis. Clinical Epidemiology, 6, 257–275
  19. Hide G. (1999). History of Sleeping Sickness in East Africa. Clin Microbiol Rev 12.
  20. Hochberg NS, Montgomery SP.,(2023). Chagas Disease. Ann Intern Med.
  21. Irish A, Whitman JD, Clark EH, Marcus R, Bern C., (2022). Updated Estimates and Mapping for Prevalence of Chagas Disease among Adults, United States. Emerg Infect Dis.
  22. José A Pérez-Molina et al., (2018). Chagas disease. The Lancet, Volume 391, Issue 10115, P82-94.
  23. Kárita Cláudia Freitas Lidani et al., (2019). Chagas Disease: From Discovery to a Worldwide Health Problem. National Library of Medicine.
  24. Liu, Q., & Zhou, X. (2015). Preventing the transmission of American trypanosomiasis and its spread into non-endemic countries. Infectious Diseases of Poverty, 4(1).
  25. Lori Stevens et al., (2011). Chapter 8 - Kissing Bugs. The Vectors of Chagas. Advances in Parasitology, Volume 75, Pages 169-192.
  26. Louis V Kirchhoff, M. (2024). Chagas disease (American trypanosomiasis) treatment & management. Medical Care, Surgical Care, Consultations.
  27. Marc J.B. Vreysen et al., (2013). Tsetse flies: Their biology and control using area-wide integrated pest management approaches. Journal of Invertebrate Pathology, Volume 112, Supplement 1.
  28. Moncayo A, Silveria AC (2017). "Current epidemiological trends of Chagas disease in Latin America and future challenges: epidemiology, surveillance, and health policies". American Trypanosomiasis – Chagas Disease (2 ed.). Elsevier.
  29. Monteiro, F.A. ∙ Weirauch, C. ∙ Felix, M. ∙ et al., (2018). Evolution, systematics, and biogeography of the Triatominae, vectors of Chagas disease. Adv Parasitol.
  30. Pépin J, Méda HA.,(2001). The epidemiology and control of human African trypanosomiasis.
  31. Pinazo, María Jesús, et al., (2010). "Diagnosis, management and treatment of chronic Chagas’ gastrointestinal disease in areas where Trypanosoma cruzi infection is not endemic." Gastroenterologia y hepatologia.
  32. Prata, Aluízio (2001). Clinical and epidemiological aspects of Chagas disease. The Lancet Infectious Diseases, Volume 1, Issue 2, 92 – 100
  33. Romay-Barja M, Boquete T, Martinez O, González M, Álvarez-Del Arco D, Benito A, BlascoHernández T. (2019). Chagas screening and treatment among Bolivians living in Madrid, Spain: The need for an official protocol. PLoS One.
  34. Salvatella R. Estimación, (2006). Cuantitativa de la enfermedad de Chagas en las Américas. Washington, D.C.: Pan American Health Association.
  35. Schofield, Chris J. et al. (2006). The future of Chagas disease control. Trends in Parasitology, Volume 22, Issue 12, 583 - 588
  36. S. C. WELBURN, P. P. SIMARRO (2009). Controlling sleeping sickness – a review. Parasitology , Volume 136 , Special Issue 14: Transmission cycles in protozoan parasites, pp. 1943 - 1949.
  37. Steverding, D. (2010). The development of drugs for treatment of sleeping sickness: a historical review. Parasite Vectors.
  38. Tanowitz HB, Kirchhoff LV, Simon D, Morris SA, Weiss LM, Wittner M. (1992). Chagas' disease. Clin Microbiol Rev 5.
  39. Van Reet, et al., (2014). In vitro and in vivo applications of reporter genes in Trypanosoma. Diss. University of Antwerp.
  40. WHO, (2024). Chagas disease (also known as American trypanosomiasis).
  41. WHO., (2023). Trypanosomiasis, human African (sleeping sickness).

This systematic review offers a comparative analysis of Trypanosoma-related diseases, focusing on African Trypanosomiasis (commonly known as sleeping sickness) caused by Trypanosoma brucei and Chagas disease caused by Trypanosoma cruzi. These illnesses represent major public health concerns in sub-Saharan Africa and Latin America, impacting millions of individuals. Although significant progress has been made in understanding the life cycles and host interactions of Trypanosoma species, their mechanisms of pathogenesis remain largely unclear. Additionally, current treatment options are limited and often associated with serious side effects. The review examines the epidemiology, clinical symptoms, and recent developments in therapeutic strategies for these diseases. Its findings aim to guide future research and clinical efforts, addressing knowledge gaps and enhancing treatment outcomes for affected communities.

Keywords : Sleeping Sickness, Host-Parasite Interaction, Vector-borne Diseases, Immune Evasion Mechanisms, Host Invasion, Global Health Burden.

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