Authors :
Priti D.Mane-Kolpe; Alfa A. Jain; Tai P.Yele; Reshma B.Devkate; Priyanka B.Parekar; Komal T.Sul; Shivraj S. Shivpuje
Volume/Issue :
Volume 7 - 2022, Issue 11 - November
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3Bqqovr
DOI :
https://doi.org/10.5281/zenodo.7420619
Abstract :
Coronavirus (covid-19) disease is caused by
SARS-COV-2 virus,it is known as severe acute respiratory
syndrome coronavirus 2, firstly seen in china in December
2019in human it is characterized by pulmonary
infection.The intension of this systematic review was to
encapsulate the evidence regarding chloroquine efficacy for
the covid -19 treatment.
Chloroquine is part of WHO (World health
organization) essential medicine model list and it is set
clinical safety profile and it is also cheap and has been
worldwide used for additionally 70 years.Chloroquine has
many activities, one of which is to alkalise the
phagolysosome, which hampers the low-pH-dependent
steps of viral replication, including uncoating and fusion, In
vitro study revealed that Chloroquine is effective at both
entry, and at post entry stages of SARS-COV-2 infection in
Vero E6 cells. In vitro, chloroquine appears as a versatile
bioactive agent reported to possess antiviral activity against
RNA viruses as diverse as rabies virus ,Dengue virus , HIV
,hepatitis C virus, hepatitis A virus, poliovirus , influenza A
and B viruses, Zika virus, influenza A H5N1 virus,
Chikungunya virus , as well as various DNA viruses such as
hepatitis B virus and herpes simplex virus.chloroquine is
effective in reducing viral replication in other infections ,
including SARS-associated coronavirus (COV)and MERSCOV.
Keywords :
SARS-COV-2, Chloroquine, Coronavirus, Severe Acute Respiratory Syndrome
Coronavirus (covid-19) disease is caused by
SARS-COV-2 virus,it is known as severe acute respiratory
syndrome coronavirus 2, firstly seen in china in December
2019in human it is characterized by pulmonary
infection.The intension of this systematic review was to
encapsulate the evidence regarding chloroquine efficacy for
the covid -19 treatment.
Chloroquine is part of WHO (World health
organization) essential medicine model list and it is set
clinical safety profile and it is also cheap and has been
worldwide used for additionally 70 years.Chloroquine has
many activities, one of which is to alkalise the
phagolysosome, which hampers the low-pH-dependent
steps of viral replication, including uncoating and fusion, In
vitro study revealed that Chloroquine is effective at both
entry, and at post entry stages of SARS-COV-2 infection in
Vero E6 cells. In vitro, chloroquine appears as a versatile
bioactive agent reported to possess antiviral activity against
RNA viruses as diverse as rabies virus ,Dengue virus , HIV
,hepatitis C virus, hepatitis A virus, poliovirus , influenza A
and B viruses, Zika virus, influenza A H5N1 virus,
Chikungunya virus , as well as various DNA viruses such as
hepatitis B virus and herpes simplex virus.chloroquine is
effective in reducing viral replication in other infections ,
including SARS-associated coronavirus (COV)and MERSCOV.
Keywords :
SARS-COV-2, Chloroquine, Coronavirus, Severe Acute Respiratory Syndrome
