Coronavirus (covid-19) disease is caused by SARS-COV-2 virus,it is known as severe acute respiratory syndrome coronavirus 2, firstly seen in china in December 2019in human it is characterized by pulmonary infection.The intension of this systematic review was to encapsulate the evidence regarding chloroquine efficacy for the covid -19 treatment. Chloroquine is part of WHO (World health organization) essential medicine model list and it is set clinical safety profile and it is also cheap and has been worldwide used for additionally 70 years.Chloroquine has many activities, one of which is to alkalise the phagolysosome, which hampers the low-pH-dependent steps of viral replication, including uncoating and fusion, In vitro study revealed that Chloroquine is effective at both entry, and at post entry stages of SARS-COV-2 infection in Vero E6 cells. In vitro, chloroquine appears as a versatile bioactive agent reported to possess antiviral activity against RNA viruses as diverse as rabies virus ,Dengue virus , HIV ,hepatitis C virus, hepatitis A virus, poliovirus , influenza A and B viruses, Zika virus, influenza A H5N1 virus, Chikungunya virus , as well as various DNA viruses such as hepatitis B virus and herpes simplex virus.chloroquine is effective in reducing viral replication in other infections , including SARS-associated coronavirus (COV)and MERSCOV.

Keywords : SARS-COV-2, Chloroquine, Coronavirus, Severe Acute Respiratory Syndrome