A Systematic Review on the Pre-Clinical Study of Cephalandra indica and Gymnema sylvestre in Diabetes Mellitus Type 2


Authors : Dr. Pooja Prakash Liman; Dr. Mrinal Ashish Nerlekar

Volume/Issue : Volume 9 - 2024, Issue 2 - February

Google Scholar : http://tinyurl.com/3m4zuz9s

Scribd : http://tinyurl.com/3tcdd76a

DOI : https://doi.org/10.5281/zenodo.10663003

Abstract : Abstract:- Homoeopathy is one of the most widely used alternative therapies, utilized all over the world, and is important in the treatment of many different illnesses. The most frequently used homeopathic medications for diabetes include Cephalandra indica, Syzygium jambolanum, phosphoric acid, Gymnema sylvestre, and Uranium nitricum. The mother tincture form is utilized as a physiological active dose according to the patient's requirements and blood glucose level.  Aim and objective – This study aimed to gather and analyze data from previous studies, in addition to examining and evaluating the anti-diabetic efficacy of Cephalandra indica and Gymnema sylvestre.  Methodology- This review covers articles that appeared until 2023. The articles were gathered using databases like Google Scholar and PubMed (Medline). We used the terms "homoeopathy," "diabetes," "in vitro," "in vivo," "Gymnema Sylvester,” and "Cephalandra indica."  Result- The review contained both in vitro and in vivo research from earlier publications. This review paper presents scientific validation for the pharmacological efficacy of Cephalandra indica and Gymnema sylvestre, as well as the likely mechanism of action shown in preclinical research.  Conclusion- Preclinical studies on homeopathic preparations of Gymnema sylvestre and Cephalandra indica have shown zero cytotoxicity, and they have a pharmacological and safety profile. The review contained both invitro and invivo research from earlier publications. In this review paper, the pharmacological activity of Cephalandra indica and Gymnema sylvestre, together with the likely mechanism of action revealed by preclinical studies, were validated scientifically. With proper research, the postulated dose conversion theory has to be verified. An overview of the existing studies on these two homoeopathic medicines is required. Despite adequate background data, human trials on diabetes mellitus using these drug candidates are lacking.

Keywords : Cephalandra indica, Diabetes, Gymnema sylvestre, in Vivo, in Vitro, Preclinical Study.

Abstract:- Homoeopathy is one of the most widely used alternative therapies, utilized all over the world, and is important in the treatment of many different illnesses. The most frequently used homeopathic medications for diabetes include Cephalandra indica, Syzygium jambolanum, phosphoric acid, Gymnema sylvestre, and Uranium nitricum. The mother tincture form is utilized as a physiological active dose according to the patient's requirements and blood glucose level.  Aim and objective – This study aimed to gather and analyze data from previous studies, in addition to examining and evaluating the anti-diabetic efficacy of Cephalandra indica and Gymnema sylvestre.  Methodology- This review covers articles that appeared until 2023. The articles were gathered using databases like Google Scholar and PubMed (Medline). We used the terms "homoeopathy," "diabetes," "in vitro," "in vivo," "Gymnema Sylvester,” and "Cephalandra indica."  Result- The review contained both in vitro and in vivo research from earlier publications. This review paper presents scientific validation for the pharmacological efficacy of Cephalandra indica and Gymnema sylvestre, as well as the likely mechanism of action shown in preclinical research.  Conclusion- Preclinical studies on homeopathic preparations of Gymnema sylvestre and Cephalandra indica have shown zero cytotoxicity, and they have a pharmacological and safety profile. The review contained both invitro and invivo research from earlier publications. In this review paper, the pharmacological activity of Cephalandra indica and Gymnema sylvestre, together with the likely mechanism of action revealed by preclinical studies, were validated scientifically. With proper research, the postulated dose conversion theory has to be verified. An overview of the existing studies on these two homoeopathic medicines is required. Despite adequate background data, human trials on diabetes mellitus using these drug candidates are lacking.

Keywords : Cephalandra indica, Diabetes, Gymnema sylvestre, in Vivo, in Vitro, Preclinical Study.

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