Pre-renal failure is the most common cause of neonatal acute renal failure (ARF), which is a significant disruption of glomerular filtration and tubular function in infants. It is brought on by intra-abdominal compartment syndrome, decreased effective blood volume, increased capillary leak, inadequate cardiac output, and renal hypoperfusion. Renal failure is a major problem that results in co-morbidities and a prolonged hospital stay in neonates who have been asphyxiated. According to the National Neonatal Perinatal Database of India, 2003, 2.5% of intramural deliveries required bag and mask ventilation, 1% required cardiac compressions, and 9% had Apgar scores below 7 at 1 minute. Perinatal asphyxia caused 23% of all neonatal fatalities, and 1.5% of all babies had symptoms of HIE. Currently, 13.12% of cases of ARF occur. In this study, sepsis was the most common cause of acute renal failure (ARF), which is comparable to earlier studies. Only 21.2% of patients were oliguric, according to Gupta et al., and there was no appreciable difference in urine output between the control and study groups. A 15% incidence of oliguria in sepsis was found by Mathur et al. and was attributable to prompt shock therapy. ARF was more common in premature infants, occurring in 79% of VLBW neonates. Another diagnosis that was anticipated was prematurity. A less severe decline in GFR and the preservation of tubular function may be the results of rapid therapy for shock with intravenous fluids and inotropic support. 38 newborns with HIE characteristics were examined by Gupta et al., who discovered that the concentration of creatinine rose as the HIE stage proceeded. 28 of the 45 ARF cases had birth asphyxia, and 7, 12, and 9 of those instances were HIE I, II, and III cases. The most common cause of ARF is sepsis, which can be identified and treated with the use of monitoring urine output, sepsis, serum creatinine, and FENa screening. Male newborns are more prone to develop ARF, and there is a positive relationship between prerenal ARF and HIE stage. Rapid management of stress may lower the likelihood that it may advance to tubular injury and, ultimately, intrinsic ARF

Keywords : Renal Failure, Prerenal ARF, New Borns, Study, Sepsis.