Authors :
Dr.Venugopal Reddy.I; Dr.Santosh Mogali
Volume/Issue :
Volume 8 - 2023, Issue 4 - April
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/44dP0Vb
DOI :
https://doi.org/10.5281/zenodo.7885055
Abstract :
Pre-renal failure is the most common cause of
neonatal acute renal failure (ARF), which is a significant
disruption of glomerular filtration and tubular function
in infants. It is brought on by intra-abdominal
compartment syndrome, decreased effective blood
volume, increased capillary leak, inadequate cardiac
output, and renal hypoperfusion. Renal failure is a
major problem that results in co-morbidities and a
prolonged hospital stay in neonates who have been
asphyxiated. According to the National Neonatal
Perinatal Database of India, 2003, 2.5% of intramural
deliveries required bag and mask ventilation, 1%
required cardiac compressions, and 9% had Apgar
scores below 7 at 1 minute. Perinatal asphyxia caused
23% of all neonatal fatalities, and 1.5% of all babies had
symptoms of HIE. Currently, 13.12% of cases of ARF
occur. In this study, sepsis was the most common cause
of acute renal failure (ARF), which is comparable to
earlier studies. Only 21.2% of patients were oliguric,
according to Gupta et al., and there was no appreciable
difference in urine output between the control and study
groups. A 15% incidence of oliguria in sepsis was found
by Mathur et al. and was attributable to prompt shock
therapy. ARF was more common in premature infants,
occurring in 79% of VLBW neonates. Another diagnosis
that was anticipated was prematurity. A less severe
decline in GFR and the preservation of tubular function
may be the results of rapid therapy for shock with
intravenous fluids and inotropic support. 38 newborns
with HIE characteristics were examined by Gupta et al.,
who discovered that the concentration of creatinine rose
as the HIE stage proceeded. 28 of the 45 ARF cases had
birth asphyxia, and 7, 12, and 9 of those instances were
HIE I, II, and III cases. The most common cause of ARF
is sepsis, which can be identified and treated with the use
of monitoring urine output, sepsis, serum creatinine, and
FENa screening. Male newborns are more prone to
develop ARF, and there is a positive relationship
between prerenal ARF and HIE stage. Rapid
management of stress may lower the likelihood that it
may advance to tubular injury and, ultimately, intrinsic
ARF
Keywords :
Renal Failure, Prerenal ARF, New Borns, Study, Sepsis.
Pre-renal failure is the most common cause of
neonatal acute renal failure (ARF), which is a significant
disruption of glomerular filtration and tubular function
in infants. It is brought on by intra-abdominal
compartment syndrome, decreased effective blood
volume, increased capillary leak, inadequate cardiac
output, and renal hypoperfusion. Renal failure is a
major problem that results in co-morbidities and a
prolonged hospital stay in neonates who have been
asphyxiated. According to the National Neonatal
Perinatal Database of India, 2003, 2.5% of intramural
deliveries required bag and mask ventilation, 1%
required cardiac compressions, and 9% had Apgar
scores below 7 at 1 minute. Perinatal asphyxia caused
23% of all neonatal fatalities, and 1.5% of all babies had
symptoms of HIE. Currently, 13.12% of cases of ARF
occur. In this study, sepsis was the most common cause
of acute renal failure (ARF), which is comparable to
earlier studies. Only 21.2% of patients were oliguric,
according to Gupta et al., and there was no appreciable
difference in urine output between the control and study
groups. A 15% incidence of oliguria in sepsis was found
by Mathur et al. and was attributable to prompt shock
therapy. ARF was more common in premature infants,
occurring in 79% of VLBW neonates. Another diagnosis
that was anticipated was prematurity. A less severe
decline in GFR and the preservation of tubular function
may be the results of rapid therapy for shock with
intravenous fluids and inotropic support. 38 newborns
with HIE characteristics were examined by Gupta et al.,
who discovered that the concentration of creatinine rose
as the HIE stage proceeded. 28 of the 45 ARF cases had
birth asphyxia, and 7, 12, and 9 of those instances were
HIE I, II, and III cases. The most common cause of ARF
is sepsis, which can be identified and treated with the use
of monitoring urine output, sepsis, serum creatinine, and
FENa screening. Male newborns are more prone to
develop ARF, and there is a positive relationship
between prerenal ARF and HIE stage. Rapid
management of stress may lower the likelihood that it
may advance to tubular injury and, ultimately, intrinsic
ARF
Keywords :
Renal Failure, Prerenal ARF, New Borns, Study, Sepsis.
