Authors : Manpreet Kaur; Anjali Bhagria; Sanjiv Duggal

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/2est949d

Scribd : https://tinyurl.com/bdfwme5n

DOI : https://doi.org/10.38124/ijisrt/26apr1930

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Because of its affordability, patient compliance, and ease of administration, the oral route is the most popular way to administer medication. However, many medications' poor water solubility restricts their absorption and therapeutic efficacy. This problem is addressed by lipid-based systems such self-emulsifying drug delivery systems (SEDDS), solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs). These nano systems improve solubility and shield medications from gastrointestinal deterioration. By bypassing first-pass metabolism, they also enhance absorption via the lymphatic route. According to studies, SLNs offer gastrointestinal protection and sustained release. NLCs enhance controlled release, stability, and drug loading. SEDDS improve lymphatic absorption, systemic availability, and dissolution. Additionally, lipid nanocarriers enhance drug performance, circulation time, and tissue distribution. Despite these advantages, issues such excipient safety, large-scale production, and stability. Even with these benefits, there are still problems like stability, large-scale production, and the safety of excipients. Lipid nanocarriers are a promising way to deliver drugs that don't dissolve well in water. BCS Class II drugs don't dissolve well, so they don't get into the body very well. The prodrug method can make a drug more bioavailable, but it needs a lot of safety testing first. Marinization, nanosizing, crystal engineering, solid dispersions, and cyclodextrins are just a few of the other methods that are used. Lipid-based carriers like SLNs, NLCs, and lipid-polymer hybrid nanoparticles make things more soluble and easier to pass through. These systems let you control the release and delivery of drugs.

Keywords : Solid Lipid Nanoparticles, Self- Emulsifying Drug Delivery System, Oral Drug Delivery, Nanostructured Lipid Carriers, Lipid.

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