Authors :
Siddhi P. Mahalle; Dr. A.M Wankhade; Dr. V. V. Paithankar; J.V. Vyas
Volume/Issue :
Volume 9 - 2024, Issue 1 - January
Google Scholar :
http://tinyurl.com/39hw74at
Scribd :
http://tinyurl.com/dmcnacem
DOI :
https://doi.org/10.5281/zenodo.10579861
Abstract :
The review article provides a comprehensive
overview of the progression of nonalcoholic fatty liver
disease (NAFLD) to nonalcoholic steatohepatitis
(NASH). It begins by discussing the global prevalence of
NAFLD and its two main components: NAFL and
NASH. The article emphasizes the rising prevalence of
NAFLD and its association with obesity and sedentary
lifestyles. It also highlights the "Asian Paradox," where
NAFL and NASH have been found in non-obese
individuals in Asia. The distinction between NAFL and
NASH is explained, along with the diagnostic methods
used to differentiate between the two conditions. The
article delves into the genetic factors associated with
NAFLD, including the PNPLA3 gene and various genetic
variants linked to fat infiltration. It also discusses the
role of insulin resistance and fructose consumption in the
progression of NAFLD to NASH. The review explores
the impact of cytokines and innate immunity, as well as
the role of gut microbiota in liver disease. In addition,
the article provides insights into the conversion process
from NAFLD to NASH, highlighting the polygenic
nature of the disease and the influence of genetic
variants. It also discusses the roles of genes, diet,
immune signatures, cytokines, liver strains, and gut
microbiota in understanding the progression from NAFL
to NASH. The comprehensive review covers a wide range
of topics, including genes present in NAFLD, insulin
resistance, fructose consumption, cytokines, and innate
immunity, and the role of gut microbiota in liver disease.
It provides a detailed analysis of the various factors
involved in the progression from NAFL to NASH.
Keywords :
Nonalcoholic Steatohepatitis (NASH), Global Prevalence, Genetic Factors, Insulin Resistance, Fructose Consumption, Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD).
The review article provides a comprehensive
overview of the progression of nonalcoholic fatty liver
disease (NAFLD) to nonalcoholic steatohepatitis
(NASH). It begins by discussing the global prevalence of
NAFLD and its two main components: NAFL and
NASH. The article emphasizes the rising prevalence of
NAFLD and its association with obesity and sedentary
lifestyles. It also highlights the "Asian Paradox," where
NAFL and NASH have been found in non-obese
individuals in Asia. The distinction between NAFL and
NASH is explained, along with the diagnostic methods
used to differentiate between the two conditions. The
article delves into the genetic factors associated with
NAFLD, including the PNPLA3 gene and various genetic
variants linked to fat infiltration. It also discusses the
role of insulin resistance and fructose consumption in the
progression of NAFLD to NASH. The review explores
the impact of cytokines and innate immunity, as well as
the role of gut microbiota in liver disease. In addition,
the article provides insights into the conversion process
from NAFLD to NASH, highlighting the polygenic
nature of the disease and the influence of genetic
variants. It also discusses the roles of genes, diet,
immune signatures, cytokines, liver strains, and gut
microbiota in understanding the progression from NAFL
to NASH. The comprehensive review covers a wide range
of topics, including genes present in NAFLD, insulin
resistance, fructose consumption, cytokines, and innate
immunity, and the role of gut microbiota in liver disease.
It provides a detailed analysis of the various factors
involved in the progression from NAFL to NASH.
Keywords :
Nonalcoholic Steatohepatitis (NASH), Global Prevalence, Genetic Factors, Insulin Resistance, Fructose Consumption, Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD).
