Alginic Acid – A Traditional Pharmaceutical Biopolymer with Modern Applications in Novel Drug Delivery


Authors : S. Dhivya; Dr. E. Anandakirouchenane

Volume/Issue : Volume 9 - 2024, Issue 8 - August


Google Scholar : https://tinyurl.com/36sznxk7

Scribd : https://tinyurl.com/fcr3fuv4

DOI : https://doi.org/10.38124/ijisrt/IJISRT24AUG738

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Polymer is a class of natural or synthetic substance or material which composed of many repeated subunits of macromolecules. Polymers are basically classified into two groups namely natural polymers and synthetic polymers. Natural biopolymers play essential roles than synthetic due to its unique properties like biodegradability, biocompatibility, and safety. Alginic acid is a biopolymer which is extracted from seaweed- algae sources; mainly from Laminaria. Due to its excellent film formation, biodegradability and biocompatibility nature, alginic acid has a widespread of applications in the drug delivery system.

Keywords : Polymers, Natural Polymers, Alginic Acid, Application.

References :

  1. Mody VV, Introduction to polymeric drug delivery , Internet J. Med. (2010 ) Update 5   ( 2 ) 1 – 2 .
  2. Lee KY, Mooney DJ Alginate: properties and biomedical applications. Progress in polymer science, (2012)., 37(1): 106–126.
  3. Xi Guo, Yan Wang, Yimin Qin, Peili Shen, Qiang Peng., Structures, properties and application of alginic acid: A review., International Journal of Biological Macromolecules, (2020)., (162)., 618-62.
  4. Shotton E, Leonard GS. Effect of intragranular and extragranular disintegrating agents on particle size of disintegrated tablets. J Pharm Sci 1976; 65: 1170–1174.
  5. Esezobo S. Disintegrants: effects of interacting variables on the tensile strengths and disintegration times of sulfaguanidine tablets. Int J Pharm 1989; 56: 207–211.
  6. Soulairol I, Sanchez-Ballester NM, Aubert A, Tarlier N, Bataille B, Quignard F, Sharkawi T., Evaluation of the super disintegrant functionnalities of alginic acid and calcium alginate for the design of orodispersible mini tablets. Carbohydr. Polym., (2018) ;197: 576-585.
  7. Tissie G, Sebastian C, Elena PP, Driot JY, Trinquand C. Alginic acid effect on carteolol ocular pharmacokinetics in the pigmented rabbit. J Ocul Pharmacol Ther 2002; 18(1): 65–73.
  8. Cohen S, Lobel E, Treygoda A, Peled Y. Novel in situ-forming opthalmic drug delivery system from alginates undergoing gelation in the eye. J Control Release 1997; 44: 201–208.
  9. Joseph I, Venkataram S. Indomethacin sustained release from alginate-gelatin or pectin-gelatin coacervates. Int J Pharm 1995; 125: 161–168.
  10. Machluf M, Regev O, Peled Y, Kost J, Cohen S.. Characterization of microencapsulated liposome systems for the controlled delivery of liposome-associated macromolecules. J Control Release 1997; 43: 35–45.
  11. Murata Y, Sasaki N, Miyamoto E, Kawashima S. Use of floating alginate gel beads for stomach-specific drug delivery. Eur J Pharm Biopharm 2000; 50(2): 221–226.
  12. Vatier J, Vallot T, Farinotti R. Antacid drugs: multiple but too often unknown pharmacological properties. J Pharm Clin 1996; 15(1): 41–51.
  13. Stanciu C, Bennett JR. Alginate/antacid in the reduction of gastrooesophageal reflux. Lancet., 1974 Jan 26;1(7848):109-11.
  14. Boisson-Vidal C, Haroun F, Ellouali M, Blondin C, Fischer AM, De Agostini A and Jozefonvicz J. Biological activities of polysaccharides from marine algae. Drugs Future 1995; 20(Dec): 1247–1249.

Polymer is a class of natural or synthetic substance or material which composed of many repeated subunits of macromolecules. Polymers are basically classified into two groups namely natural polymers and synthetic polymers. Natural biopolymers play essential roles than synthetic due to its unique properties like biodegradability, biocompatibility, and safety. Alginic acid is a biopolymer which is extracted from seaweed- algae sources; mainly from Laminaria. Due to its excellent film formation, biodegradability and biocompatibility nature, alginic acid has a widespread of applications in the drug delivery system.

Keywords : Polymers, Natural Polymers, Alginic Acid, Application.

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe