Alzheimer's Disease: Advances in Early Diagnosis and Emerging Therapeutics


Authors : Pathuni Hema Geethika; Chintapalli Veera Venkata Sireesha; Jasthi Satya Gayatri Devi

Volume/Issue : Volume 10 - 2025, Issue 7 - July


Google Scholar : https://tinyurl.com/23sysydc

Scribd : https://tinyurl.com/3hdtzwf3

DOI : https://doi.org/10.38124/ijisrt/25jul1719

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Abstract : Alzheimer's disease is a chronic, progressive neurodegenerative disorder marked by cognitive decline, behavioral changes, and eventual loss of independent function. It is the leading cause of dementia globally, posing a significant social, economic, and medical burden. Recent scientific breakthroughs have shifted the focus from symptomatic treatment to early diagnosis and disease-modifying interventions. This review explores the molecular pathogenesis of AD, advances in early diagnostic techniques including novel biomarkers and neuroimaging, and emerging therapeutics ranging from monoclonal antibodies to gene therapy and lifestyle interventions. By integrating early detection strategies with emerging therapeutics, we move closer to intercepting AD at its earliest and most manageable stage.

Keywords : Alzheimer’s, Neurological Loss, MRI, Antibodies, Personalized Medicines.

References :

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  2. Cummings J, Lee G, Ritter A, Zhong K. (2024). Alzheimer’s disease drug development pipeline: 2024. Alzheimer’s & Dementia: Translational Research & Clinical Interventions 10:e12488.
  3. Long JM, Holtzman DM. (2019). Alzheimer disease: An update on pathobiology and Treatment Strategies.
  4. Van Dyck CH, Swanson CJ, Aisen P,et al.(2023). Lecanemab in early Alzheimer’s disese. New England Journal of Medicine, 388(1), 9-21.
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  6. Henstridge CM, Hyman BT, Spires-Jones TL. (2019). Beyond the neuron-cellular inteeractions early in alzheimer disesse pathogenesis. Nature Reviews Neuroscience, 20(2), 94-108.
  7. Dementia Prevention,Intervention, and care :2020 report of the Lancet Commission. The Lancet, 396(10248),413-446.
  8. Alzheimer’s Association. (2024). 2024 Alzheeimer’s Disease Facts and Figures. Alzheeimer’s & Dementia, 20(3), 321-418.
  9. Hampel H, Hardy J, Blennow K, et al. (2021). The amyloid-βpathway in Alzheimer’s disease. Molecular psychiatry, 23,, 5481-5503.
  10. Ferreira D, Nordberg A, Westman E. (2020). Biomarkers for Alzheimer’s disease: current status and prospects for the future. Journal of Internal Medicine, 287(3), 232-252.

Alzheimer's disease is a chronic, progressive neurodegenerative disorder marked by cognitive decline, behavioral changes, and eventual loss of independent function. It is the leading cause of dementia globally, posing a significant social, economic, and medical burden. Recent scientific breakthroughs have shifted the focus from symptomatic treatment to early diagnosis and disease-modifying interventions. This review explores the molecular pathogenesis of AD, advances in early diagnostic techniques including novel biomarkers and neuroimaging, and emerging therapeutics ranging from monoclonal antibodies to gene therapy and lifestyle interventions. By integrating early detection strategies with emerging therapeutics, we move closer to intercepting AD at its earliest and most manageable stage.

Keywords : Alzheimer’s, Neurological Loss, MRI, Antibodies, Personalized Medicines.

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Paper Submission Last Date
31 - December - 2025

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