Authors : Nargish Tomar; Niranjan Kumar M.Optom.

Volume/Issue : Volume 10 - 2025, Issue 1 - January

Google Scholar : https://tinyurl.com/2mru73cv

Scribd : https://tinyurl.com/msujtcny

DOI : https://doi.org/10.5281/zenodo.14724973

Abstract : Keratoconus is a progressive, non-inflammatory ectatic disorder of the cornea, characterized by progressive thinning and protrusion, resulting in a conical shape that leads to significant refractive and visual impairment. The condition typically manifests during adolescence or early adulthood and may progress throughout life if left untreated. While its precise etiology remains uncertain, keratoconus is widely considered to arise from a multifactorial interplay of genetic predisposition, environmental influences—such as persistent mechanical trauma from chronic eye rubbing—and systemic associations, including connective tissue disorders like Marfan syndrome. This paper examines the progression of keratoconus across its clinical stages, detailing its transition from mild symptoms to advanced corneal deformation and visual dysfunction. The disease progresses through distinct stages, marked by increasing corneal thinning, steepening, and deterioration of optical quality. In its early phases, patients may present with mild refractive errors, but as the disease advances, they often experience significant visual disturbances, including blurred vision, irregular astigmatism, and, in severe cases, corneal scarring that can severely impair visual acuity. These progressive changes can profoundly impact patients’ quality of life, often leading to psychological challenges such as frustration, anxiety, or depression. Early diagnosis and prompt intervention are critical to mitigating disease progression and improving outcomes. Therapeutic strategies, including corneal cross-linking, custom-designed contact lenses, and surgical interventions, have demonstrated efficacy in stabilizing the corneal structure, enhancing vision, and preserving functional quality of life. However, the effective management of keratoconus is influenced by socioeconomic and cultural factors, which often dictate access to healthcare services. In resource-limited settings, delayed diagnosis and restricted availability of advanced treatments can exacerbate disease progression and its associated consequences. This paper advocates for a multidimensional approach to keratoconus management, emphasizing the integration of medical therapies with psychological and social support systems. By addressing the diverse impacts of keratoconus across its clinical spectrum, this review aims to highlight strategies to optimize patient care and improve overall quality of life.

Keywords : Keratoconus, Corneal Cross-Linking, Vision Impairment, Quality of Life [QoL],The National Eye Institute Visual Function Questionnaire [NEI-VFQ],Keratoconus Outcomes Research Questionnaire [KORQ], etc.

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