Authors :
Sangeeta Saraswat; Anju Goyal; Maya Sharma; Ankita Joshi
Volume/Issue :
Volume 10 - 2025, Issue 1 - January
Google Scholar :
https://tinyurl.com/yfp6ses5
Scribd :
https://tinyurl.com/yywr7jtd
DOI :
https://doi.org/10.5281/zenodo.14651288
Abstract :
In recent years, the Pharmaceutical industry
has witnessed remarkable advancements in drug
delivery technologies, a trend expected to continue.
Among the various dosage forms, tablets remain one of
the most preferred options due to their practicality, ease
of administration, and patient compliance. Innovations
in tablet formulations have opened doors to enhanced
customization of therapeutic agents, optimizing their
effectiveness. Numerous novel drug delivery systems
have been developed, providing improved therapeutic
outcomes and addressing challenges associated with
traditional formulations. This review highlights one such
innovative approach, tablet-in-tablet systems. These
systems offer significant advantages, such as sustained
release of active pharmaceutical ingredients (APIs) and
improved safety profiles, while ensuring better patient
adherence. By transforming conventional drug delivery
methods, such as injectables or oral solid dosage forms,
into advanced formulations, tablet-in-tablet technology
holds immense potential to revolutionize drug
administration practices.
Keywords :
Tablet-in-Tablet Systems, Sustained-Release Tablets, Innovative Drug Delivery Systems, Dual-Layer Tablets.
References :
- Noyes WS. Bicycle Lamp Backat U.S. Patent, 567, 157, September; c1896.
- Liu T, Shi Y, Li J, Jiang W, Yin T, Zhang Y, et al. Nifedipine di-matrix depot tablets prepared by compression coating for obtaining zero-order release. Drug Development and Industrial Pharmacy. 2018 Sep 2;44(9):1426-33. doi. https://doi.org/10.1080/03639045.2018.1458859
- Ozekia Y, Andoa M, Watanabea Y, Danjob K. Evaluation of novel onestep dry-coated tablets as a platform for delayed-release tablets. J Control Release. 2004;95:51-60. Doi: 10.1016/j.jconrel.2003.10.028
- Wardrop J, Jaber AB, James W, Ayres JW. Multiplelayercompressioncoated tablets: formulation and humidity studies of novel chewable amoxicillin / clavulanate tablet formulations. Drug Dev Ind Pharm. 1998;24(8):729-736.
- Jariwala DM, Patel HP, Desai CT, Shah SA, Shah DR. A Review on Multiple Compressed Tablets. Journal of pharmaceutical sciences and Boi scientific research. 2016;6(3):371-379.
- Patel J S, Thakkar D, Patel K N, Patel K J. A Review on Bilayer Tablet, Journal of Drug Discovery and Therapeutics, 1(3), 2013, 40-48.
- Mishra A, Bhatt K G, Kothiyal P. Review: Bilayer Tablet and Evaluation, International Journal of Drug and Research and Technology, 3(2), 2013, 21-30.
- Kavitha K, Divya A et al. Bilayer Tablet Technology: An Overview, Journal of Applied Pharmaceutical Sciences, 1(8), 2011, 43-47.
- Musle K, Payghan S A, Disuza J J. Formulation, Evaluation and Development of Bilayer Tablet, International Journal of Pharmaceutical Research and Development (IJPRD), 3(10), 2011, 80-87.
- Brito Raj S, Sravani G, Bhanupriya N, Veerupakshi M. Design and Evaluation of Sustained Release Bilayer Tablet of Metformin Hydrochloride with Metoprolol Tartrate, International Journal of Novel Trends in Pharmaceutical Sciences, 1(1), 2011, 1-5.
- Rajendra N and Natarajan R. Formulation and Evaluation of Sustained Release Bilayer Tablet of Metformin HCL And Pioglitazone HCL, International Journal of Current Pharmaceutical Research, 3(3), 2011, 118-122.
- Nagaraju R and Kaza R. Formulation and Evaluation of Bilayer Sustained Release Tablet Of Salbutamol And Theophylline, International journal of pharmaceutical science and nano technology, 2(3), 2009, 638-646.
- Veerareddy P and Manthri R. Formulation and Evaluation of Compression Coated Piroxicam Tablets for Colon Specific Drug Delivery, Acta Pharma, 52(3), 2010, 281- 294.
- Durga Prasad Pattanayak and Subas C Dinda. Bilayer Tablet Formulation of Metformin Hydrochloride and Glimepiride: A novel approach to improve therapeutic efficacy, international journal of drug discovery and herbal research, 1(1), 2011, 1-4.
- Cremer K. Pharmaceutical Application of Layer Tablet, AAPS Pharm Sci. Tech, 2001.
- Ramana G, Sushma M, Arun Y. Formulation and Evaluation of Sustained Release Bilayer Tablet of Ambroxol Hydrochloride, International Journal Innovative Pharmaceutical Research, 1(3), 2010, 61-65.
- Deore R K, Kunchu K, Theeta G. Preparation and Evaluation of Sustained Release Matrix Tablets of Tramadol Hydrochloride, Tropical Journal of Pharmace Research, 9(3), 2010, 275-281.
- TABLET IN TABLET A REVIEW (ajrcps.com)
- (PDF) A Brief Overview on Tablet and It's Types (researchgate.net)
- Medical Definition of Tablet (rxlist.com)
- [PPT] Types of Tablets and Their Charecteristics - Pharmawiki.in
- The Theory and Practice of Industrial Pharmacy by Lachman and Lieberman (3rd Editn): Free Download, Borrow, and Streaming: Internet Archive
- https://www.researchgate.net/publication/51049127/figure/fig8/AS:203006583808005@1425411949064/Schematic-depicting-drug-delivery-from-pre-encapsulated-drug-loaded-liposomes.png
In recent years, the Pharmaceutical industry
has witnessed remarkable advancements in drug
delivery technologies, a trend expected to continue.
Among the various dosage forms, tablets remain one of
the most preferred options due to their practicality, ease
of administration, and patient compliance. Innovations
in tablet formulations have opened doors to enhanced
customization of therapeutic agents, optimizing their
effectiveness. Numerous novel drug delivery systems
have been developed, providing improved therapeutic
outcomes and addressing challenges associated with
traditional formulations. This review highlights one such
innovative approach, tablet-in-tablet systems. These
systems offer significant advantages, such as sustained
release of active pharmaceutical ingredients (APIs) and
improved safety profiles, while ensuring better patient
adherence. By transforming conventional drug delivery
methods, such as injectables or oral solid dosage forms,
into advanced formulations, tablet-in-tablet technology
holds immense potential to revolutionize drug
administration practices.
Keywords :
Tablet-in-Tablet Systems, Sustained-Release Tablets, Innovative Drug Delivery Systems, Dual-Layer Tablets.