Implementation Research (IR) is solving implementation problems for proven interventions. Prevention of mother to child transmission of Human immunodeficiency virus (PMTCT) is one of the modes of HIV prevention amongst abstinence from sex, being faithful to a mutual faithful partner that is not infected, consistent and correct use of condoms and use of sterilized sharp objects. Nigeria being ranked as the second highest burdened HIV infected nation has a national prevalence of 1.4% while Bayelsa state in the South-South geopolitical zone, and in the Niger Delta region has a prevalence of 1.9% resulting in about 45, 866 person living with the virus in the state. A global and best practice is therefore required for all positive clients to be on retention which is the act to be on anti – retroviral therapy or treatment which can be achieved by stakeholders’ processes, community engagement, stakeholders’ mobilization, advocacies for intervention, support by PHC in the community, health systems dynamics, empowering communities, Engagement of implementers and broader systems effects all geared to improved knowledge on HIV/AIDS, increase HCT/HTS retention in care and prevention. UNAIDS vision of 90:90:90 and to end AIDS by 2030 can only be achieved if the entire population have in-depth knowledge of HIV/AIDS and all stakeholders collectively continue to strive for quality in the midst of any challenge, protection of human rights and zero discrimination. With community support and other partners, the response can be fast-tracked both at the local, state, national and the global level. Together, we can end AIDS epidemic by 2030.

Keywords : Implementation research, Prevention of motherto child transmission of HIV (PMTCT), Retention, Human immunodeficiency virus/ Acquired immunodeficiency syndrome (HIV/AIDS) Antiretroviral therapy, HIV counseling and testing/ HIV testing services (HCT/HTS), Information, education and communication (IEC) materials.