Authors : Dr. Sumedh Lathi; Dr. Mohit Thakur; Dr. Sadashiv Daokar; Dr. Priyanka Chavan; Dr. Sana Khan; Dr. Nikita Sarate; Dr. Shubhangi Gaysmindar

Volume/Issue : Volume 11 - 2026, Issue 1 - January

Google Scholar : https://tinyurl.com/44ubf7h6

Scribd : https://tinyurl.com/4m8f5x5c

DOI : https://doi.org/10.38124/ijisrt/26jan1311

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Aim: To compare and evaluate the effect of Nitrofurantoin, Triple Antibiotic Paste and Oil based Calcium hydroxide on the push-out bond strength of MTA based sealer.  Material and Methods: The study included sixty (60) mature, single-rooted mandibular teeth that had been recently extracted. Calculus, debris, and soft tissue remains were extracted from the teeth using an ultrasonic scaler. F3 Protaper rotary instruments were used to instrument each sample. After the specimens were instrumented, Based on the location of the intracanal medicament, specimens were split into three experimental groups at random.: Group 1: Triple Antibiotic Paste (TAP), Group 2: Nitrofurantoin (NIT), and Group 3: Oil-based Calcium Hydroxide (n = 20). MTA fillapex was used for obturation following the removal of intracanal medication. A universal testing machine was used to determine the push out bond strength.  Results: Compared to the nitrofurantoin group, the triple antibiotic paste group produced even greater bond. When compared to the other test groups, the Neopex group's bond strength was significantly weakened.  Conclusion: It may be inferred that Triple Antibiotic Paste, Nitrofurantoin, and oil based calcium hydroxide significantly increased the bonding capacity of resin-based sealer. There are notable differences between Triple Antibiotic Paste, Nitrofurantoin, and oil based calcium hydroxide mean push out bond strength levels.

Keywords : MTA Fillapex Sealer, Triple Antibiootic Paste, Nitrofurantoin,Universal Testing Machine.

References :

1. Kunhappan S, Kunhappan N, Saraf KK, Kridutt V. Nonsurgical endodontic treatment of teeth associated with large periapical lesion using triple antibiotic paste and mineral trioxide aggregate apical plug: A case series. J Conserv Dent 2017;20:141‑5.J. Clerk Maxwell, A Treatise on Electricity and Magnetism, 3rd ed., vol. 2. Oxford: Clarendon, 1892, pp.68-73.
2. Taneja S, Kumari M. Use of triple antibiotic paste in the treatment of large periradicular lesions. J Investig Clin Dent 2012;3:72‑6.K.
3. Gupta A, Kumar M, Taneja S. Effect of intracanal calcium hydroxide dressing on the push out bond strength of AH Plus, MTA Fillapex®, and endosequence BC sealer. Endodontology 2020;32:33‑7.
4. Akcay M, Arslan H, Topcuoglu HS, Tuncay O. Effect of calcium hydroxide  and double and triple antibiotic pastes on the bond strength of epoxy resin‑based sealer to root canal dentin. J Endod 2014;40:1663‑7.
5. Sarıcam E, Ince Yusufoglu S, Kucuk M, Geneci F, Ocak M, Celik HH. Micro‑computed tomography assessment of triple antibiotic paste removal using different irrigation methods. Eur Oral Res 2022;56:49‑54.
6. Harshitha VS, Ranjini MA, Nadig RR. Antibacterial efficacy of nisin, calcium hydroxide, and triple antibiotic paste in combination with chitosan as an intracanal medicament against Enterococcus faecalis – An in vitro study. J Conserv Dent 2022;25:504‑9.
7. Khanvilkar U, Pawar S, Bandekar S, Dhok V, Arora S, Pawar AM, et al. Scanning electron microscopy analysis of the intratubular radicular dentin penetration of calcium hydroxide, triple antibiotic paste, and nitrofurantoin. J Pers Med 2023;13:1554.
8. Hoshino E, Kurihara‑Ando N, Sato I, Uematsu H, Sato M, Kota K, et al. In‑vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J 1996;29:125‑30.
9. Arslan H, Capar ID, Saygili G, Uysal B, Gok T, Ertas H, et al. Efficacy of various irrigation protocols on the removal of triple antibiotic paste. Int Endod J 2014;47:594‑9.
10. Ertan G, Karasulu Y, Güneri T. Degradation and gastrointestinal stability of nitrofurantoin in acidic and alkaline media. Int J Pharm 1993;96:243‑8.
11. Alrahman MS, Faraj BM, Dizaye KF. Assessment of nitrofurantoin as an experimental intracanal medicament in endodontics. Biomed Res Int 2020;2128473:1‑13.
12. Mohammadi Z, Dummer PM. Properties and applications of calcium hydroxide in endodontics and dental traumatology. Int Endod J. 2011 Aug;44(8):697-730. doi: 10.1111/j.1365-2591.2011.01886.x. Epub 2011 May 2.
13. Fava LR, Saunders WP. Calcium hydroxide pastes: classification and clinical indications. Int Endod J. 1999 Aug;32(4):257-82.doi:10.1046/j.1365-2591.1999.00232.
14. Madhuri GV, Varri S, Bolla N, Mandava P, Akkala LS, Shaik J. Comparison of bond strength of different endodontic sealers to root dentin: An in vitro push-out test. J Conserv Dent. 2016 Sep-Oct;19(5):461-4. doi: 10.4103/0972-0707.190012.
15. Afkhami F, Razavi S, Ghabraei S. The effect of different intracanal medicaments on the dislodgement resistance of mineral trioxide aggregate. BMC Oral Health. 2022 May 25;22(1):207. doi: 10.1186/s12903-022-02213-2.
16. Barbizam JV, Trope M, Tanomaru-Filho M, Teixeira EC, Teixeira FB. Bond strength of different endodontic sealers to dentin: push-out test. J Appl Oral Sci. 2011 Nov-Dec;19(6):644-7. doi: 10.1590/s1678-77572011000600017.
17. Nair R, Khandelwal S, Gohil C, Maurya N, Parakh S, Nawale A. Comparative evaluation of the effect of nitrofurantoin and triple antibiotic paste on the push-out bond strength of epoxy resin sealer: An in vitro study. J Conserv Dent Endod. 2025 Feb;28(2):187-192. doi: 10.4103/JCDE.JCDE_795_24. Epub 2025 Feb 3.
18. Roy D, Kataki R, Das L, Jain K. Influence of 2% chlorhexidine on the dislodgement resistance of AH plus, bioroot RCS, and GuttaFlow 2 sealer to dentin and sealer‑dentin interface. J Conserv Dent Endod 2022;25:642‑7.
19. Asawaworarit W, Yachor P, Kijsamanmith K, Vongsavan N. Comparison of the Apical Sealing Ability of Calcium Silicate-Based Sealer and Resin-Based Sealer Using the Fluid-Filtration Technique. Med Princ Pract. 2016;25(6):561-565. doi: 10.1159/000450577. Epub 2016 Sep 5.
20. Kettlewell R, Jones C, Felton TW, Lagator M, Gifford DR. Insights into durability against resistance from the antibiotic nitrofurantoin. NPJ Antimicrob Resist 2024;2:41.