Authors : Mohammad Ebrahimi

Volume/Issue : Volume 10 - 2025, Issue 2 - February

Google Scholar : https://tinyurl.com/y9awt9xk

Scribd : https://tinyurl.com/mvmxnw84

DOI : https://doi.org/10.5281/zenodo.14949822

Abstract : In recent years, cell transplantation strategies have shifted focus toward utilizing cell byproducts, particularly the cell secretome—a collection of proteins and bioactive molecules secreted by cells. Initially defined in the context of bacterial proteins, the concept of the secretome has expanded to encompass a wide range of biological systems, offering significant potential in medical applications. Secretome therapy, which leverages the regenerative properties of stem cell-derived factors, has emerged as a promising approach for tissue repair, disease treatment, and diagnostic innovation. The secretome’s ability to reduce inflammation, promote tissue repair, and stimulate functional recovery positions it as a versatile tool in modern medicine. However, the translation of secretome therapy from preclinical studies to clinical practice faces several challenges, including issues of standardization, scalability, safety, regulatory compliance, and disease-specific optimization. By addressing these challenges through rigorous research, collaboration, and innovative solutions, secretome therapy can realize its full potential as a transformative treatment modality. This review underscores the importance of advancing our understanding of secretome biology and developing effective strategies to harness its therapeutic benefits, ultimately improving patient outcomes across a spectrum of medical conditions.

Keywords : Cell Secretome, Secretome Therapy, Regenerative Medicine, Clinical Applications, Clinical Challenges.

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