Authors :
N.V.L. Suvarchala Reddy; M. Ganga Raju; P. Anusha; D. Pushyami Sudha; P. Shrivani
Volume/Issue :
Volume 9 - 2024, Issue 4 - April
Google Scholar :
https://tinyurl.com/mryc5tx5
Scribd :
https://tinyurl.com/2ex3bp8e
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24APR1478
Abstract :
Modern pharmacotherapy includes analgesic
and anti-inflammatory medicines as essential components
to relieve pain and inflammation brought on by a variety
of medical diseases. Robust screening techniques are
essential for the identification of possible candidates with
appropriate safety and effectiveness profiles in the search
and development of new analgesic and anti-inflammatory
medications. This study looks at the many screening
methods used in preclinical studies to assess new drugs'
analgesic and anti-inflammatory quality. Conventional
techniques like the tail flick, hot plate, and writhing’s tests
measure analgesic activity by having animals respond to
unpleasant stimuli. Comparably, anti-inflammatory
activity is frequently assessed using assays like the cotton
pellet granuloma test, which gauges tissue granuloma
formation, and the carrageenan-induced paw edema
model, which measures inflammation. These traditional
techniques offer insightful information about the
pharmacological effects of test substances. Despite the
wide range of screening techniques available, each strategy
has advantages and disadvantages. Preclinical studies are
more reliable and have higher predictive value when
various assays and techniques are integrated into a tiered
screening strategy. Furthermore, the successful translation
of preclinical findings to human applications depends on
taking into account translational variables including
species differences and clinical relevancies. As a result,
choosing the right screening techniques is critical to the
effective identification and characterization of new
analgesic and anti-inflammatory drugs.
Keywords :
Analgesic; Anti-Inflammmatory; Hot Plate; Writing Test; Carrageenan Induced Paw Edema; Prostaglandins; Arthriti.
Modern pharmacotherapy includes analgesic
and anti-inflammatory medicines as essential components
to relieve pain and inflammation brought on by a variety
of medical diseases. Robust screening techniques are
essential for the identification of possible candidates with
appropriate safety and effectiveness profiles in the search
and development of new analgesic and anti-inflammatory
medications. This study looks at the many screening
methods used in preclinical studies to assess new drugs'
analgesic and anti-inflammatory quality. Conventional
techniques like the tail flick, hot plate, and writhing’s tests
measure analgesic activity by having animals respond to
unpleasant stimuli. Comparably, anti-inflammatory
activity is frequently assessed using assays like the cotton
pellet granuloma test, which gauges tissue granuloma
formation, and the carrageenan-induced paw edema
model, which measures inflammation. These traditional
techniques offer insightful information about the
pharmacological effects of test substances. Despite the
wide range of screening techniques available, each strategy
has advantages and disadvantages. Preclinical studies are
more reliable and have higher predictive value when
various assays and techniques are integrated into a tiered
screening strategy. Furthermore, the successful translation
of preclinical findings to human applications depends on
taking into account translational variables including
species differences and clinical relevancies. As a result,
choosing the right screening techniques is critical to the
effective identification and characterization of new
analgesic and anti-inflammatory drugs.
Keywords :
Analgesic; Anti-Inflammmatory; Hot Plate; Writing Test; Carrageenan Induced Paw Edema; Prostaglandins; Arthriti.
