Authors :
Suresh B. Patankar; Anupama Gorde; Sagar Patankar; Rajesh Raje; Chadrashekhar Gillurkar; Pranjal Ausekar; Gaurav Patil
Volume/Issue :
Volume 8 - 2023, Issue 4 - April
Google Scholar :
https://bit.ly/43uxUln
Scribd :
https://bit.ly/40EEqmY
DOI :
https://doi.org/10.5281/zenodo.7866294
Abstract :
Traditional medicine has demonstrated its
efficacy in treating a vast array of ailments, including
infectious ones, over the years. Because of their
immunomodulatory and other pharmacological actions,
polyherbal formulations are suitable for COVID-19
infection prevention. After two Covaxin doses, human
immunological markers were shown to diminish a few
days later. This study evaluated the effect of Abayakasthaa
plus (IP) capsules on the immune levels of volunteers who
had two Covaxin injections. The IP is a mixture of around
11 indigenous plant extracts that have been demonstrated
to possess immune-boosting properties independently. In a
multispecialty hospital in central India, 30 volunteers were
randomised into two groups of 15 each for a pilot
randomised experiment for 28 days. Four immunological
indicators (IgG) & Covaxin Dose (CD3+, CD4+, and CD8+
cell count) were evaluated on the 0th and 28th day
following immunisation using blood samples. For
independent samples, the t-test helped compare mean
biomarker values between two groups, while the paired ttest helped compare marker values in follow-ups.At day
28, the mean (geometric) concentration of IgG antibodies
in the test group was substantially greater than in the
placebo group (p=0.04). Although the concentration of the
marker reduced considerably in the placebo group (p =
0.021), it stayed virtually constant in the test group (p =
0.824). On day 28, other metrics were comparable and
showed negligible differences between groups. The results
of a preliminary study show that herbal preparations
increase COVID-19 vaccination-induced immunogenicity
for an extended length of time. To justify the results, more
research with bigger cohorts is necessary.
Keywords :
COVID-19 vaccination, Clinical trial,Herbal formulation, Immunomodulation.
Traditional medicine has demonstrated its
efficacy in treating a vast array of ailments, including
infectious ones, over the years. Because of their
immunomodulatory and other pharmacological actions,
polyherbal formulations are suitable for COVID-19
infection prevention. After two Covaxin doses, human
immunological markers were shown to diminish a few
days later. This study evaluated the effect of Abayakasthaa
plus (IP) capsules on the immune levels of volunteers who
had two Covaxin injections. The IP is a mixture of around
11 indigenous plant extracts that have been demonstrated
to possess immune-boosting properties independently. In a
multispecialty hospital in central India, 30 volunteers were
randomised into two groups of 15 each for a pilot
randomised experiment for 28 days. Four immunological
indicators (IgG) & Covaxin Dose (CD3+, CD4+, and CD8+
cell count) were evaluated on the 0th and 28th day
following immunisation using blood samples. For
independent samples, the t-test helped compare mean
biomarker values between two groups, while the paired ttest helped compare marker values in follow-ups.At day
28, the mean (geometric) concentration of IgG antibodies
in the test group was substantially greater than in the
placebo group (p=0.04). Although the concentration of the
marker reduced considerably in the placebo group (p =
0.021), it stayed virtually constant in the test group (p =
0.824). On day 28, other metrics were comparable and
showed negligible differences between groups. The results
of a preliminary study show that herbal preparations
increase COVID-19 vaccination-induced immunogenicity
for an extended length of time. To justify the results, more
research with bigger cohorts is necessary.
Keywords :
COVID-19 vaccination, Clinical trial,Herbal formulation, Immunomodulation.
