Hospital Information System (SIMRS) is a computerized-based application developed for medical record data management. The implementation of SIMRS in RSIA Resti Mulya is still found obstacles, among others, there are users who have difficulty using SIMRS, a lack of understanding of SIMRS, limited resources, lack of leadership support, and the use of SIMRS that has not utilized centralized data. The purpose of this study is to describe the factors that affect the effectiveness of SIMRS implementation using the Human-Organization Technology (HOT) Fit evaluation model. The type of research used is a quantitative approach. The population of this study is the user (user) of SIMRS application in RSIA Resti Mulya, with a sample of a total population of 85 people. The results of research with correlation showed there is a relationship between the availability of facilities and the quality of information with the effectiveness of SIMRS implementation and no relationship between personal capability, effectiveness of training

Keywords : Hot Fit model, Hospital Management Information System. Application.