Authors : Koteru Aparna; M. Sadan; G. Kranthi kumar

Volume/Issue : Volume 10 - 2025, Issue 5 - May

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DOI : https://doi.org/10.38124/ijisrt/25may078

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Abstract : Counterfeit pharmaceuticals pose a significant threat to public health and safety, leading to potentially harmful consequences such as treatment failure, drug resistance, and even death. Therefore, the development and implementation of effective analytical methods for detecting counterfeit pharmaceuticals are paramount. This review explores various analytical techniques employed for the detection of counterfeit pharmaceuticals, including spectroscopic methods (such as UV-Vis, FTIR, and Raman spectroscopy), chromatographic techniques (such as HPLC and GC-MS), mass spectrometry, nuclear magnetic resonance (NMR) spectroscopy, and immunoassays. Each method's principles, advantages, limitations, and applications in pharmaceutical analysis are discussed. Additionally, advancements in technology, such as portable and handheld devices, are examined for their potential to enhance on-site detection capabilities. Furthermore, the role of regulatory authorities and international collaborations in combating counterfeit pharmaceuticals through analytical methods is elucidated. By leveraging these analytical tools, stakeholders in the pharmaceutical industry, regulatory agencies, and law enforcement can work together to mitigate the risks associated with counterfeit drugs and safeguard public health.

Keywords : Counterfeit Pharmaceuticals, Analytical Methods, Spectroscopy, Chromatography, Mass Spectrometry.

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