The current research work deals with the investigation of the anti-angiogenesis study of the aerial parts of Catharanthus roseus. The activity was evaluated after the 21 days of incubation. The work showed that the plants material is highly potent in terms of antiangiogenesis which is a type of cancer. The extraction was carried out in ethyl acetate so as to get the flavonoid rich fraction and the positive control we used was also flavonoids.