Authors : Fatima S. Mohammed; Reuben Robinson

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/ysmj8v5c

Scribd : https://tinyurl.com/mw4krdfm

DOI : https://doi.org/10.38124/ijisrt/26apr2266

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Abstract : The awareness and general acceptability of herbal drugs in modern medical practice are increasing globally, offering critical solutions to escalating public and environmental health challenges. Antimicrobial resistance (AMR) is a rapidly growing environmental threat, particularly in semi-arid and developing regions where water sanitation is vulnerable and pathogenic contamination is high. Finding accessible, biodegradable, and effective plant-based remedies is vital for community health resilience. This study evaluated the antibacterial efficacy of the ethyl acetate fraction of Cassia occidentalis Linn. aqueous seed extract against selected clinical pathogens (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). The fraction exhibited significant, concentration-dependent antibacterial activity. At the highest concentration of 100 mg/ml, the extract was most potent against E. coli (28.00 mm), followed by S. aureus (22.00 mm) and P. aeruginosa (21.00 mm), showing statistically significant differences compared to the standard antibiotic, Amoxicillin. The results highlight the potential of C. occidentalis as a viable, eco-friendly source for novel antibacterial agents, particularly against resilient Gram-negative bacteria that typically pollute environmental reservoirs and exhibit low susceptibility due to outer membrane lipopolysaccharides and multi-drug efflux pumps.

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