Antidermatophyte Activity of Essential oils of Fresh Zanthoxylum zanthoxyloides Lam Leaves and Fruits Against Trichophyton rubrum and Antifungal Ointment Formulation Test

Authors : Tanga Tanga Régis; Tchabon Raymond; Ngo Nouck Carine; Ndzobo Ndzana E. joelle; Mounbain Francis; Djendja Parfait; Ndoubarou Francklin; Yaka Nsasso Christelle; Nnanga Nga; Tchoumbougnang François

Volume/Issue : Volume 6 - 2021, Issue 1 - January

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Dermatophytes are fungi responsible for superficial mycoses called dermatophytoses. The aim of this work was to evaluate the anti-dermatophyte activity in vitro of essential oils from the leaves and fresh fruits of Zanthoxylum zanthoxyloides. For this purpose, the essential oils from the leaves and fresh fruits of Z. zanthoxyloides harvested in Bamena were extracted by hydro-distillation using a Clevenger. The extraction yields were 1.12% for the fruits and 0.04% for the leaves. The chemical composition of these extracts was determined by gas chromatography (GC) and by gas chromatography coupled with mass spectrometry (GC / MS). The results of this analysis made it possible to identify 59 compounds in the essential oil of fruits, with citronellol as the major compound (18.63%) while in the leaf extract 58 compounds were identified, with as major compound, citronellol acetate (23.4%). The essential oils of Z. zanthoxyloides showed MICs of 3600, 4200 and 4420 ppm respectively for the essence of the leaves, fruits and the mixture of fruits and leaves, the dermal application of essential oils did not cause any modification behavior including no erythema or edema on the skin, no convulsions, no tremors, or diarrhea. Food and water consumption remained normal in the treated groups during the experiment compared to the first day of the study. A formulation trial of an antifungal ointment and conformity tests led to the production of a product whose pharmaceutical form was called: ZANTHOZOLE ointment.

Keywords : Dermatophytes; Essential Oils; Acute Dermal Toxicity; Ointment Formulation.


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