Oxidative stress is the primary cause of many
human ailments, including aging. Synthetic antioxidants
are unaffordable and are associated with severe effects.
This necessitates the need for alternative antioxidant
agents. This investigation aimed to determine the
antioxidant activities and qualitative phytochemical
composition of DCM and MeOH blend extracts of root
barks of Carissa edulis and leaves of Caesalpinia volkensii.
The antioxidant assays included ferric reducing
antioxidant power (FRAP), H2O2 radical scavenging and
DPPH radical scavenging activities, as well as total
flavonoid and total phenolic content tests. The extracts
revealed potent FRAP and DPPH and H2O2 radical
scavenging activities, including a considerable amount of
total flavonoids and phenolics contents. The C. edulis
extract noted better antioxidant activities than C.
volkensii extract. The antioxidant effects of the two
studied extracts were concentration-dependent. In
addition, the C. edulis extract had a considerably higher
amount of total phenolic and total flavonoid contents
relative to C. volkensii extract. Phenolics, terpenoids,
alkaloids, cardiac glycosides, saponins, steroids, and
flavonoids were detected in the qualitative phytochemical
analysis, except for alkaloids and steroids in C. volkensii
extract and cardiac glycosides in C. edulis extract. In
conclusion, the two extracts have potent antioxidant
activities and are endowed with phytochemicals
associated with antioxidant activities. The two extracts,
therefore, may be used as alternative antioxidant agents.
Keywords : Antioxidant; oxidative stress; phytochemicals; flavonoids; phonolics