Authors : Nkiruka Millicent Amadi; Amara Olivia Izueke; Azona Worship Amadi

Volume/Issue : Volume 11 - 2026, Issue 6 - June

Google Scholar : https://tinyurl.com/crdx9ky2

Scribd : https://tinyurl.com/y9yhnmtb

DOI : https://doi.org/10.38124/ijisrt/26jun1807

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Abstract : Canarium schweinfurthii derivatives exhibit multiple pharmacological activities and provide health benefits to various organs. Gastric ulcer is considered one of the most common digestive diseases in the present century. Inflammation and tissue alteration as a result of excess alcohol consumption are one of the key factors that disrupt gastric mucosal barrier. C. schweinfurthii fruit pulps extract, rich in bioactive components which may be beneficial to treatment of stomach ulceration. This study aimed to assess the therapeutic effect of aqueous extract of the Canarium schweinfurthiifruit pulp on the stomach against ethanol induced gastric ulceration using albino rat models.The study was carried out using thirty (30) albino rats aged 7- 10 weeks weighing between 150 and 185g grouped into 6 cages of 5 rats each. Group1 [Negative Control] received food and water while Group 2 [Positive control] received Food, water and 0.5ml ethanol. Group 3, 4 and 5 received food, water, 200, 400, 800mg/kg/bw of Canarium schweinfurthii fruit pulp with 0.5ml of ethanol respectively. Group 6 served as drug control group and received food, water with oral daily dose of Cimetidine 50mg/kg b.wt. The studied organs were harvested under anaesthesia (chloroform), ulceration index was observed and recorded. The excised organ tissue homogenate was prepared while others processed using histological technique. In the ulcerative index result, tested antioxidative mediators varied significantly across the groups. The negative control recorded the highest value whereas the cimetidine group had the lowest. These findings were also confirmed through a histopathological analysis of gastric tissue. In conclusion, Canarium schweinfurthii fruit pulp extract administration significantly reduced assessed parameters in dose-dependent manner, with high-dose group showing values closest to the cimetidine group providing a dose dependent curative effect.

Keywords : Therapeutic Effect, Canarium Schweinfurthi, Stomach ulcer, Ethanol, Cimetidine.

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