Authors :
Rachna Sharma; Rucha Lakhne; Dr. R S Gupta
Volume/Issue :
Volume 7 - 2022, Issue 10 - October
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3TZnZ1j
DOI :
https://doi.org/10.5281/zenodo.7344683
Abstract :
:- Population explosion is a global phenomenon
and has robust impact on various global issues. It is a
major concern for public policy makers and
governments. Hence, there is a need for an ideal
contraceptive with maximum efficacy and safety. Many
plant based products have antispermatogenic activity
that needs to be investigated. In this context, the current
study evaluates the antispermatogenic potential of
methanolic crude extract of roots of Momordica dioica on
experimental rats. Experiments were carried out by
administering the root extract of M. dioica at different
dose levels of 10, 20 and 50 mg/kg body weight/day for 60
days on male albino rats. The reproductive organ
weights of experimental rats were analyzed manually of
different dose levels. Effect of the drug was examined by
serum Testosterone, LH and FSH levels. Sperm
morphology and motility was observed in semen of
cauda epididymis. Histological sections of rat testis and
epididymis were studied. The effect of root extract of M.
dioica showed significant decrease in the weights of
reproductive organs and hormonal levels.There was a
significant change and decrease in sperm morphology
and motility respectively in the experimental rats after
administering with the above drug. Histological
examination of testis and epididymis of experimental
rats showed degeneration as compared to the control
group. The present research concludes the effectiveness
of M. dioica root in posing the antispermatogenic
activity.
Keywords :
Antispermatogenic, Sperm Morphology, Sperm Motility, Momordica dioica, Contraception.
:- Population explosion is a global phenomenon
and has robust impact on various global issues. It is a
major concern for public policy makers and
governments. Hence, there is a need for an ideal
contraceptive with maximum efficacy and safety. Many
plant based products have antispermatogenic activity
that needs to be investigated. In this context, the current
study evaluates the antispermatogenic potential of
methanolic crude extract of roots of Momordica dioica on
experimental rats. Experiments were carried out by
administering the root extract of M. dioica at different
dose levels of 10, 20 and 50 mg/kg body weight/day for 60
days on male albino rats. The reproductive organ
weights of experimental rats were analyzed manually of
different dose levels. Effect of the drug was examined by
serum Testosterone, LH and FSH levels. Sperm
morphology and motility was observed in semen of
cauda epididymis. Histological sections of rat testis and
epididymis were studied. The effect of root extract of M.
dioica showed significant decrease in the weights of
reproductive organs and hormonal levels.There was a
significant change and decrease in sperm morphology
and motility respectively in the experimental rats after
administering with the above drug. Histological
examination of testis and epididymis of experimental
rats showed degeneration as compared to the control
group. The present research concludes the effectiveness
of M. dioica root in posing the antispermatogenic
activity.
Keywords :
Antispermatogenic, Sperm Morphology, Sperm Motility, Momordica dioica, Contraception.
