Authors : Shaza Fahmawi; Abed El-Rahman Abu-Dalu

Volume/Issue : Volume 10 - 2025, Issue 6 - June

Google Scholar : https://tinyurl.com/35m7yzx6

DOI : https://doi.org/10.38124/ijisrt/25jun1772

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Note : Google Scholar may take 30 to 40 days to display the article.

Abstract : The application of nanotechnology to blood detoxification and viral clearance represents a paradigm shift in the management of chronic kidney disease (CKD) and other persistent systemic conditions. Conventional dialysis and filtration methods, though beneficial, exhibit critical limitations in effectively eliminating small, protein-bound toxins and viral particles from the bloodstream. Nanoparticles, with their unique physicochemical properties such as high surface- area-to-volume ratio, tunable surface chemistry, and the capacity for functionalization, provide unprecedented opportunities for targeted and efficient blood purification. Recent advances have seen the development of a variety of nanoparticle-based systems, including magnetic nanoparticles for pathogen removal, carbon nanotube-enhanced membranes for improved toxin clearance, and polymeric nanoparticles capable of neutralizing endotoxins and modulating inflammatory responses. This article provides a comprehensive examination of the theoretical foundations, technological innovations, preclinical and clinical trial outcomes, and statistical analyses surrounding the application of nanoparticles in blood detoxification. The findings underscore both the transformative potential of these nanodevices and the significant challenges related to biocompatibility, scalability, and long-term safety that must be addressed prior to widespread clinical adoption. (Bhattacharya et al., 2021; Patel et al., 2022; Zhang et al., 2023)

Keywords : Nanoparticles, Blood Detoxification, Viral Clearance, Nanodevices for Blood Filtration, Chronic Kidney Disease (CKD), Protein-Bound Toxins Removal, Magnetic Nanoparticles, Polymeric Nanoparticles, Carbon Nanotube Membranes, Hemodialysis Alternatives, Systemic Infections Management, Cytokine Storm Mitigation, Biocompatibility Challenges, Targeted Blood Purification Strategies, Biomedical Nanotechnology, Adsorptive Hemofiltration Techniques, Nanoparticle Surface Functionalization, Viral Sequestration Mechanisms, and Immunomodulation Therapies.

References :

1. Patel, A. et al. (2022). Advances in Nanoparticle-Based Detoxification for Chronic Kidney Disease. Journal of Nanomedicine Research, 15(4), 230-244.
2. Bhattacharya, K. et al. (2021). Magnetic Nanoparticles for Viral Sequestration from Blood: Applications in Infectious Disease Control. Nanotechnology in Medicine, 32(2), 112-126.
3. Chen, L. et al. (2023). Biocompatibility Enhancement of Nanoparticles for Blood Purification: Surface Modification Approaches. Advanced Healthcare Materials, 12(1), 1012-1024.
4. Zhang, Y. et al. (2023). Integration of Nanoparticles into Extracorporeal Circuits for Continuous Blood Detoxification. Nature Biomedical Engineering, 7(5), 480-495.
5. Wang, S. et al. (2024). Theranostic Nanodevices for Simultaneous Blood Filtration and Real-Time Monitoring. ACS Nano, 18(3), 2231-2245.