Authors :
Awad El-Hakeem; Sharon Fernando; Dunura Perera; Romaana Baksh
Volume/Issue :
Volume 10 - 2025, Issue 9 - September
Google Scholar :
https://tinyurl.com/4jxpcewd
Scribd :
https://tinyurl.com/4smcsckh
DOI :
https://doi.org/10.38124/ijisrt/25sep1136
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Note : Google Scholar may take 30 to 40 days to display the article.
Abstract :
The most common complications post pediatric cardiac surgeries are postoperative arrhythmias. They greatly
influence adverse postoperative events, duration of stay in intensive care unit (ICU), and patient outcome [1] [2].
Regardless of surgical advancements, perioperative care and pain management, the rate of arrhythmias in current
patient populations is significant [2] [3].
This narrative review aims to investigate the risk factors of postoperative arrhythmias in pediatric cardiac surgery,
highlight preventive strategies that are evidence-based and give an overview of prevalent management techniques.
Risk factors attributable to arrhythmogenesis are patient oriented or pertain to surgical specificities. Patient-related
risks include age, prior cardiac abnormalities and electrolytic irregularities. Surgical risks encompass the type of procedure
performed, time period undertaken for cardiopulmonary bypass procedures, and intraoperative myocardial ischemia [1]
[2].
Preventive strategies involve conscientious perioperative monitoring, rectifying metabolic abnormalities, defensive
approaches for the myocardium, and utilising prophylactic antiarrhythmic pharmacotherapy in high-risk patients.
Continual electrocardiographic monitoring is an effective means of early diagnosis, aiding in diminishing advancements of
arrhythmias to hemodynamic damage [3]. Several types of arrhythmia require distinct therapeutic techniques. Therapeutic
strategies range from pharmacotherapy with amidarone, to using pacemakers.
Perioperative protocol developments, better intraoperative monitoring technologies, and advancing
pharmacotherapy, showcase promise in improving preventive and management methods. Research in longevity and
durability of the studies is required, along with multicenter collaborations to produce uniform protocols and predictive
prototypes customised for the Pediatric population.
Future directions emphasise on refining risk prediction tools, assessing new therapies, and incorporating biomarker-
based risk stratification into clinical practice. Providing current evidence and focusing on blind spots, makes this review
beneficial for clinicians and researchers, with practical comprehension for better discernment, encouraging
further research in Pediatric cardiac care.
Keywords :
Pediatric Cardiac Surgery, Postoperative Arrhythmias, Junctional Ectopic Tachycardia, Risk Factors, Prevention, Management.
References :
- Delaney, J. W., Moltedo, J. M., Dziura, J. D., Kopf, G. S., & Snyder, C. S. (2006). Early postoperative arrhythmias after pediatric cardiac surgery. Journal of Thoracic and Cardiovascular Surgery, 131(6), 1296–1300.
- Lapmahapaisan, S., Sateantantikul, N., & Maisat, W. (2025). Revisiting risk factors and incidence of postoperative tachyarrhythmias in pediatric cardiac surgery. Scientific Reports, 15, Article 7297.
- Ishaque, S., Akhtar, S., Ladak, A. A., Martins, R. S., Memon, M. K. Y., Kazmi, A. R., Mahmood, F., Haque, A. u. (2022). Early postoperative arrhythmias after pediatric congenital heart disease surgery: a 5-year audit from a lower- to middle-income country. Acute and Critical Care, 37(2), 217–223.
- Alsaied T, Yu S, Humphrey B, Correa A, Jenkins KJ. Critical arrhythmia in postoperative cardiac children: Recognition and management. Pediatr Crit Care Med. 2016. Available from: https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5525472/
- Brown R, et al. Timing of removal of pacing wires following paediatric cardiac surgery. PubMed. 2007. Available from: https://pubmed.ncbi.nlm.nih.gov/17868500/
- Choudhury S. Myocardial protection in paediatric cardiac surgery. RCS Eng. 2023. Available from: https://publishing.rcseng.ac.uk/doi/10.1308/rcsann.2023.0004
- Davidson A, et al. Severe electrolyte disorders following cardiac surgery. PubMed Central. 2004. Available from: https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC1065069/
- Elton C, et al. Emergency diagnosis and management of pediatric arrhythmias. PMC. 2003. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938490/
- Green P, et al. Congenital cardiac surgery without routine placement of wires for pacing. PubMed. 2008. Available from: https://pubmed.ncbi.nlm.nih.gov/17977466/
- Kharbanda O, et al. Management by hypothermia of junctional ectopic tachycardia. PMC. 2021. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC8457265/
- Kumar RK. Teamwork in pediatric heart care. PMC. 2001. Available from: https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2922661/
- Lee J, et al. Safety and efficacy of prophylactic amiodarone in preventing early postoperative JET. PubMed. 2016. Available from: https://pubmed.ncbi.nlm.nih.gov/26818850/
- Leeds Teaching Hospitals NHS Trust. Intravenous amiodarone administration guidelines. LTHT Paediatric ICU Guide. 2025. Available from: https://www.leedsformulary.nhs.uk/docs/PICU%20amiodarone%20monograph.pdf
- Mishra R, et al. Myocardial protection in pediatric cardiac surgery. PubMed. 2013. Available from: https://pubmed.ncbi.nlm.nih.gov/23305570/
- Narayanasamy S, et al. Simulation training for pediatric cardiac emergencies: Enhancing team preparedness. J Pediatr Nurs. 2021.
- Ravikumara M, et al. Management of postoperative arrhythmias in pediatric patients. PubMed. 2012. Available from: https://pubmed.ncbi.nlm.nih.gov/22895911/
- Smith T, Johnson K. Pediatric perioperative fluid and electrolyte management. PubMed Central. 2023. Available from: https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC10718623/
- Smith A, Johnson P, Lee R. Long-term success in pediatric heart surgery. Number Analytics. 2024. Available from: https://www.numberanalytics.com/ blog/pediatric-heart-surgery-success-strategies
- Hoffman, T. J., Wernovsky, G., Wieand, T. S., Cohen, M. L., Jennings, A. C., Vetter, V. L., Godinez, R. I., J. William Gaynor, Spray, T. L., & Rhodes, L. A. (2002). The Incidence of Arrhythmias in a Pediatric Cardiac Intensive Care Unit. 23(6), 598–604. https://doi.org/10.1007/s00246-001-0079-y
- Kabbani, M. S., Al Taweel, H., Kabbani, N., & Al Ghamdi, S. (2017). Critical arrhythmia in postoperative cardiac children: Recognition and management. Avicenna Journal of Medicine, 7(3), 88–95. https://doi.org/10.4103/ajm.AJM_14_17
- Pfammatter, J.-P., Bachmann, D. C. G., Wagner, B. P., Pavlovic, M., Berdat, P., Carrel, T., & Pfenninger, J. (2001). Early postoperative arrhythmias after open-heart procedures in children with congenital heart disease. Pediatric Critical Care Medicine, 2(3), 217–222. https://doi.org/10.1097/00130478-200107000-00005
- Romer, A. J., Tabbutt, S., Etheridge, S. P., Fischbach, P., Ghanayem, N. S., Reddy, V. M., Sahulee, R., Tanel, R. E., Tweddell, J. S., Gaies, M., Banerjee, M., Retzloff, L., Zhang, W., & Patel, A. R. (2019). Atrioventricular block after congenital heart surgery: Analysis from the Pediatric Cardiac Critical Care Consortium. The Journal of Thoracic and Cardiovascular Surgery, 157(3), 1168-1177.e2. https://doi.org/10.1016/j.jtcvs.2018.09.142
- Bar-Cohen, Y., & Silka, M. J. (2012). Management of Postoperative Arrhythmias in Pediatric Patients. Current Treatment Options in Cardiovascular Medicine, 14(5), 443–454. https://doi.org/10.1007/s11936-012-0195-4
- Zhou, S., Liu, L., Jin, X., Dorikun, D., & Ma, S. (2025). Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis. Frontiers in Pediatrics, 13. https://doi.org/10.3389/fped.2025.1508329
- Entenmann, A., Michel, M., Egender, F., Hessling, V., & Kramer, H.-H. (2016). Impact of different diagnostic criteria on the reported prevalence of junctional ectopic tachycardia after pediatric cardiac surgery. Pediatric Critical Care Medicine, 17(9), 845–851. https://doi.org/10.1097/PCC.0000000000000853
- Alp, H., Narin, C., Baysal, T., & Sarıgül, A. (2013). Prevalence of and risk factors for early postoperative arrhythmia in children after cardiac surgery. Pediatrics International, 56(1), 19–23. https://doi.org/10.1111/ped.12209
- Muralidhar, K (2014). Recent advances in postoperative care of pediatric cardiac surgical patients. Journal of Pediatric Critical Care. 1(2):p 26-38, Apr–Jun 2014. | DOI: 10.21304/2014.0102.00016
- Seghaye, M.-C. (2003). The clinical implications of the systemic inflammatory reaction related to cardiac operations in children. Cardiology in the Young, 13(3), 228–239. doi:10.1017/S1047951103000465
- Rekawek, J., Kansy, A., Miszczak-Knecht, M., Manowska, M., Bieganowska, K., Brzezinska-Paszke, M., Szymaniak, E., Turska-Kmieć, A., Maruszewski, P., Burczyński, P., & Kawalec, W. (2007). Risk factors for cardiac arrhythmias in children with congenital heart disease after surgical intervention in the early postoperative period. The Journal of Thoracic and Cardiovascular Surgery, 133(4), 900–904. https://doi.org/10.1016/j.jtcvs.2006.12.011
- Alotaibi, R. K., Saleem, A. S., Alsharef, F. F., Alnemer, Z. A., Saber, Y. M., Abdelmohsen, G. A., & Bahaidarah, S. A. (2022). Risk factors of early postoperative cardiac arrhythmia after pediatric cardiac surgery: A single-center experience. Saudi Medical Journal, 43(10), 1111–1119. https://doi.org/10.15537/smj.2022.43.10.20220275
- Yasa, K. P., Katritama, A. A., Harta, I. K. A. P., & Sudarma, I. W. (2024). Prevalence and risk factors analysis of early postoperative arrhythmia after congenital heart surgery in pediatric patients. Journal of Arrhythmia, 40(2), 356–362. https://doi.org/10.1002/joa3.13011
- Lahiri, S., Gil, W., Daria, S., Joshua, G., Parul, J., Redmond, B., & Elizabeth, W. (2020). Genetic abnormalities/syndromes significantly impact perioperative outcomes of conotruncal heart defects. Annals of Pediatric Cardiology, 13(1), 38–45. https://doi.org/10.4103/apc.APC_51_19
- Peretto, G., Durante, A., Limite, L. R., & Cianflone, D. (2014). Postoperative arrhythmias after cardiac surgery: Incidence, risk factors, and therapeutic management. Cardiology Research and Practice, 2014, 615987. https://doi.org/10.1155/2014/615987
- Shahidi, M., Bakhshandeh, H., Rahmani, K., & Afkhamzadeh, A. (2019). Hypomagnesaemia and other electrolytes imbalances in open and closed pediatrics cardiac surgery. Pakistan Journal of Medical Sciences, 35(2), 353–359. https://doi.org/10.12669/pjms.35.2.367
- Mentzer, R. M., Alegre, C. A., & Nolan, S. P. (1976). The effects of dopamine and isoproterenol on the pulmonary circulation. The Journal of Thoracic and Cardiovascular Surgery, 71(6), 807–814. https://pubmed.ncbi.nlm.nih.gov/5634
- Driscoll, D., Gillette, P., Lewis, R., & et al. (1979). Comparative hemodynamic effects of isoproterenol, dopamine, and dobutamine in the newborn dog. Pediatric Research, 13(9), 1006–1009. https://doi.org/10.1203/00006450-197909000-00011
- Tamazyan V, Khachatryan A, Batikyan A, Harutyunyan H, Aryal B, Achuthanandan S, Hollander G. Sepsis-induced atrial fibrillation: Can we predict and prevent this high-risk complication? Cureus. 2025 Jun;17(6):e85387. doi:10.7759/cureus.85387. PMID: 40621331; PMCID: PMC12229231.
- Taylor M, et al. Prophylactic amiodarone reduces junctional ectopic tachycardia. OUHSC CME. 2016. Available from: https://ouhsc.cloud-cme.com/assets/ ouhsc/pdf/9-14-16%20AmioJETACH.pdf
- Choi HS, Park S, Kweon J, Oh S, Shakya SJ, Heo HB, Kim J, Woong-Han. The teamwork structure, process, and context of a paediatric cardiac surgery team in Mongolia: A mixed‐methods approach. Int J Health Plann Manage. 2022. Available from: https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC9545841/
- Borgman KY, et al. A genetic contribution to risk for postoperative junctional ectopic tachycardia. Heart Rhythm. 2011;8(7):1062–9. Available from: https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC3215859/
- Glikson M, Burri H, Abdin A, Cano O, Curila K, De Pooter J, et al. European Society of Cardiology (ESC) clinical consensus statement on indications for conduction system pacing, with special contribution of the European Heart Rhythm Association of the ESC. Europace. 2025;27(4):euaf050. doi:10.1093/europace/euaf050. Available from: https://doi.org/10.1093/europace/euaf050
- Anselmi, A., Abbate, A., Girola, F., Nasso, G., Biondi-Zoccai, G. G. L., Possati, G., & Gaudino, M. (2004). Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: A review of evidence. European Journal of Cardio-Thoracic Surgery, 25(3), 304–311. https://doi.org/10.1016/j.ejcts.2003.12.003
43. Li, Y., Wang, H., Wang, Y., & Zhou, X. (2018). Postoperative arrhythmias in pediatric patients after cardiac surgery: Clinical analysis and risk factors. Medicine, 97(36), e12171. https://doi.org/10.1097/MD.0000000000012171
The most common complications post pediatric cardiac surgeries are postoperative arrhythmias. They greatly
influence adverse postoperative events, duration of stay in intensive care unit (ICU), and patient outcome [1] [2].
Regardless of surgical advancements, perioperative care and pain management, the rate of arrhythmias in current
patient populations is significant [2] [3].
This narrative review aims to investigate the risk factors of postoperative arrhythmias in pediatric cardiac surgery,
highlight preventive strategies that are evidence-based and give an overview of prevalent management techniques.
Risk factors attributable to arrhythmogenesis are patient oriented or pertain to surgical specificities. Patient-related
risks include age, prior cardiac abnormalities and electrolytic irregularities. Surgical risks encompass the type of procedure
performed, time period undertaken for cardiopulmonary bypass procedures, and intraoperative myocardial ischemia [1]
[2].
Preventive strategies involve conscientious perioperative monitoring, rectifying metabolic abnormalities, defensive
approaches for the myocardium, and utilising prophylactic antiarrhythmic pharmacotherapy in high-risk patients.
Continual electrocardiographic monitoring is an effective means of early diagnosis, aiding in diminishing advancements of
arrhythmias to hemodynamic damage [3]. Several types of arrhythmia require distinct therapeutic techniques. Therapeutic
strategies range from pharmacotherapy with amidarone, to using pacemakers.
Perioperative protocol developments, better intraoperative monitoring technologies, and advancing
pharmacotherapy, showcase promise in improving preventive and management methods. Research in longevity and
durability of the studies is required, along with multicenter collaborations to produce uniform protocols and predictive
prototypes customised for the Pediatric population.
Future directions emphasise on refining risk prediction tools, assessing new therapies, and incorporating biomarker-
based risk stratification into clinical practice. Providing current evidence and focusing on blind spots, makes this review
beneficial for clinicians and researchers, with practical comprehension for better discernment, encouraging
further research in Pediatric cardiac care.
Keywords :
Pediatric Cardiac Surgery, Postoperative Arrhythmias, Junctional Ectopic Tachycardia, Risk Factors, Prevention, Management.