River Nile is an essential water resource for both drinking water and irrigation in Egypt. This study assessed water quality at River Nile and three polluted ecosystems namely Omr Beck drain, Sherbeen drain, Manzalalake and investigated the impacts of this water on some organs of African Catfish (Clariasgariepinus). The physicochemical parameters of the water were measured seasonally at three ecosystems compared to River Nile in the period fromwinter 2017and autumn 2018. Also, this study evaluates the negative impacts of all measured parameters on the general health of the fish. The data indicated that EC, HCO3-, SO42-, Cl-, Ca2+, Mg2+, Na+, K+, TH, TA and NO2- recorded higher concentration in Omr Beck drain water than those in other polluted ecosystems and River Nile. The data indicated that NO3-, NH4+ and DRP recorded higher concentrations in Manzala lake water than those water of RiverNile.

Keywords : River Nile, Omr Beck drain, Sherbeen drain, Manzala lake, ClariasgariepinusHeavy metals, Pesticides and diaxions, Scenedesmusobliqnus, hydroxyapatite nano rods.