Authors : Emmanuel Roland A. Lendio; Neña Jane G. Mabale; Jovira G. Ramos; Keith Alexandra O. Soco

Volume/Issue : Volume 11 - 2026, Issue 7 - July

Google Scholar : https://tinyurl.com/y852p9j2

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DOI : https://doi.org/10.38124/ijisrt/26jul647

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Abstract : Tablet disintegration is essential for immediate-release oral dosage forms because it facilitates tablet breakup and subsequent drug dissolution. This study assessed Aloe vera mucilage as a natural disintegrant in 100 mg directcompression paracetamol tablets. Seven formulations were prepared: one negative control without a disintegrant, Aloe vera mucilage formulations containing two, five, and ten percent by weight, and carboxymethyl starch formulations at corresponding concentrations. The extracted mucilage was characterized by percentage yield, organoleptic properties, qualitative solubility or dispersion behavior, swelling index, moisture content, and Fourier transform infrared spectroscopy. Powder blends were evaluated for flow and packing properties, while tablets were assessed for weight variation, dimensions, breaking force, friability, disintegration, dissolution, and drug content. Mean mucilage yield was 0.17 percent with a standard deviation of 0.07 percent. The mean swelling index was 120.00 percent with a standard deviation of 52.92 percent, and mean moisture content was 16.90 percent with a standard deviation of 3.34 percent. Among the Aloe vera formulations, the ten percent formulation showed the strongest disintegrant performance, with a mean disintegration time of 40.83 seconds and a standard deviation of 4.54 seconds, and 99.00 percent drug release at 45 minutes. All formulation means fell within the 90 to 110 percent drug-content range used in the study. Carboxymethyl starch generally produced better powder flow and faster disintegration. Aloe vera mucilage therefore demonstrated concentration-dependent and promising natural-disintegrant activity, although optimization of powder flow, drying, moisture control, and manufacturing consistency is required before scale-up.

Keywords : Aloe Vera Mucilage; Natural Disintegrant; Paracetamol Tablets; Direct Compression; Tablet Disintegration; Dissolution; Pharmaceutical Excipient.

References :

1. K. P. Kesare, T. M. Rasala, A. M. Ittadwar, and D. S. Sahare, “Natural disintegrating agents in pharmaceutical formulation and development: Review,” International Journal of Pharmaceutical Sciences Review and Research, vol. 80, no. 1, pp. 23-28, May-Jun. 2023, doi: 10.47583/ijpsrr.2023.v80i01.005.
2. S. Kanaujiya and S. Kumar, “Comparative study of natural disintegrants, selection criteria for superdisintegrants,” World Journal of Pharmaceutical Sciences, vol. 10, no. 5, pp. 56-63, May 2022, doi: 10.54037/WJPS.2022.100503.
3. M. M. Tosif et al., “A comprehensive review on plant-derived mucilage: Characterization, functional properties, applications, and its utilization for nanocarrier fabrication,” Polymers, vol. 13, no. 7, art. no. 1066, Mar. 2021, doi: 10.3390/polym13071066.
4. K. B. Ilango et al., “Mucilage of Coccinia grandis as an efficient natural polymer-based pharmaceutical excipient,” Polymers, vol. 14, no. 1, art. no. 215, Jan. 2022, doi: 10.3390/polym14010215.
5. Royal Botanic Gardens, Kew, “Aloe vera (L.) Burm.f.,” Plants of the World Online, 2026. Accessed: Jul. 12, 2026.
6. C. Liu et al., “Extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, a polysaccharide from Aloe vera: A review,” Molecules, vol. 24, no. 8, art. no. 1554, Apr. 2019, doi: 10.3390/molecules24081554.
7. Y. Bai, Y. Niu, S. Qin, and G. Ma, “A new biomaterial derived from Aloe vera-acemannan from basic studies to clinical application,” Pharmaceutics, vol. 15, no. 7, art. no. 1913, Jul. 2023, doi: 10.3390/pharmaceutics15071913.
8. A. Mahmood et al., “Aloe vera-based polymeric network: A promising approach for sustained drug delivery, development, characterization, and in vitro evaluation,” Gels, vol. 9, no. 6, art. no. 474, Jun. 2023, doi: 10.3390/gels9060474.
9. A. S. Jadhav, A. K. Shewale, and M. A. Bhutkar, “Evaluation of Aloe vera and Hibiscus rosa-sinensis mucilage as a binder in different tablet formulations,” Asian Journal of Pharmacy and Technology, vol. 10, no. 1, pp. 29-37, 2020, doi: 10.5958/2231-5713.2020.00007.0.
10. T. Hong, J.-Y. Yin, S.-P. Nie, and M.-Y. Xie, “Applications of infrared spectroscopy in polysaccharide structural analysis: Progress, challenge and perspective,” Food Chemistry: X, vol. 12, art. no. 100168, Dec. 2021, doi: 10.1016/j.fochx.2021.100168.
11. J. S. Banding, J. G. L. Garay, A. S. H. Lomondot, S. H. A. Pandapatan, and M. A. R. Pepito, “Phytochemical profiling, development, and evaluation of Crescentia cujete fruit pulp as a natural disintegrant in compressed paracetamol tablets,” International Journal of Innovative Science and Research Technology, vol. 10, no. 6, pp. 2678-2704, Jun. 2025, doi: 10.38124/ijisrt/25jun1784.
12. K. K. Moravkar et al., “Traditional and advanced flow characterization techniques: A platform review for development of solid dosage form,” Indian Journal of Pharmaceutical Sciences, vol. 82, no. 6, pp. 945-957, Nov.-Dec. 2020, doi: 10.36468/pharmaceutical-sciences.726.
13. United States Pharmacopeial Convention, “General Chapter <1174> Powder Flow,” USP-NF, Rockville, MD, USA, official text updated May 1, 2024.
14. O. A. Adeleye, “Relationship between compression pressure, mechanical strength and release properties of tablets,” Polymers in Medicine, vol. 49, no. 1, pp. 27-33, Jan.-Jun. 2019, doi: 10.17219/pim/111888.
15. United States Pharmacopeial Convention, “General Chapter <1217> Tablet Breaking Force,” USP-NF, Rockville, MD, USA, 2018, doi: 10.31003/USPNF_M99937_02_01.
16. United States Pharmacopeial Convention, “General Chapter <1216> Tablet Friability,” USP-NF, Rockville, MD, USA, harmonized revision approved Sep. 30, 2022.
17. United States Pharmacopeial Convention, “General Chapter <701> Disintegration,” USP-NF, Rockville, MD, USA, 2019.
18. United States Pharmacopeial Convention, “General Chapter <711> Dissolution,” USP-NF, Rockville, MD, USA, 2011.
19. United States Pharmacopeial Convention, “Acetaminophen Tablets,” USP-NF, Rockville, MD, USA, 2021, doi: 10.31003/USPNF_M200_05_01.
20. K. Abebe, T. B. Beressa, and B. T. Yimer, “In-vitro evaluations of quality control parameters of paracetamol tablets marketed in Gondar City, Northwest Ethiopia,” Drug, Healthcare and Patient Safety, vol. 12, pp. 273-279, Dec. 2020, doi: 10.2147/DHPS.S282420.